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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and often has a poor prognosis. The present study investigated the role of the low affinity nerve growth factor receptor CD271 as a putative therapy target in HNSCC ...
Yannick Foerster +7 more
doaj +1 more source
NTRK Fusion in Non-Small Cell Lung Cancer: Diagnosis, Therapy, and TRK Inhibitor Resistance
Neurotrophic tropomyosin receptor kinase (NTRK) gene fusion has been identified as an oncogenic driver of various solid tumors, and it is rare in non-smalll cell lung cancer (NSCLC) with a frequency of approximately less than 1%.
Fangfang Liu +5 more
doaj +1 more source
Cones, Spins and Heat Kernels [PDF]
The heat kernels of Laplacians for spin 1/2, 1, 3/2 and 2 fields, and the asymptotic expansion of their traces are studied on manifolds with conical singularities. The exact mode-by-mode analysis is carried out for 2-dimensional domains and then extended
Bañados +48 more
core +3 more sources
NTRK fusions are validated oncogenic drivers of various adult and pediatric tumor types, including thyroid cancer, and serve as a therapeutic target. Recently, tropomyosin receptor kinase (TRK) inhibitors, such as entrectinib and larotrectinib, display ...
Qing-Xiang Yu +6 more
doaj +1 more source
A cluster version of the GGT sum rule [PDF]
We discuss the derivation of a ``cluster sum rule'' from the Gellmann-Goldberger-Thirring (GGT) sum rule as an alternative to the Thomas-Reiche-Kuhn (TRK) sum rule, which was used as the basis up to now.
Ajzenberg-Selove +23 more
core +4 more sources
Con el objetivo de evaluar los peligros geológicos que afectan a la I.E.S. Ayusuma en la ladera del mismo nombre, distrito de Coasa, provincia Carabaya, región Puno, el día 20 de octubre del 2013 se inspeccionó la zona en compañía de los representantes ...
Norma Luz Sosa Senticala
doaj +1 more source
Asymptotic behaviours of the heat kernel in covariant perturbation theory [PDF]
The trace of the heat kernel is expanded in a basis of nonlocal curvature invariants of $N$th order. The coefficients of this expansion (the nonlocal form factors) are calculated to third order in the curvature inclusive.
A. O. Barvinsky +5 more
core +2 more sources
The Genomic and Proteomic Profiles of NTRK Genes and Trk Receptors in Liver Hepatocellular Carcinoma
Background: The neurotrophic tyrosine kinase (NTRK) gene family includes NTRK1, NTRK2, and NTRK3, which encode tropomyosin receptor kinases TrkA, TrkB, and TrkC, respectively.
Hejing Wang +4 more
doaj +1 more source
ALK, NUT, and TRK are rare molecular aberrations that are pathognomonic for specific rare tumors. In low frequencies, however, they are found in a wide range of other tumor entities.
Marie-Isabelle Glückstein +7 more
doaj +1 more source
Bacteria use K+-uptake transporters differentially for adaptation in varying growth conditions. In Mycobacterium tuberculosis, two K+-uptake systems, the Trk comprising the CeoB and CeoC proteins and the Kdp consisting of the two-component system (TCS ...
Moloko C. Cholo +3 more
doaj +1 more source

