Results 31 to 40 of about 83,065 (165)

Pharmacological Topics of Bone Metabolism: A Novel Bisphosphonate for the Treatment of Periodontitis

Journal of Pharmacological Sciences, 2008
It has been reported that the pharmacological characteristics of bisphosphonates vary depending on the side chain attached to the carbon atom of the P-C-P bond.
Hisashi Shinoda, Sadaaki Takeyama, Keiko Suzuki, Shinobu Murakami, Shoji Yamada   +4 more
doaj   +1 more source

NTRK Fusions in 1113 Solid Tumors in a Single Institution

Diagnostics, 2022
Most NTRK fusions occur at very low frequencies in various common cancers. Recent recommendations on NTRK testing recommend immunohistochemistry (IHC) as the initial test for tumor types with a low frequency of NTRK fusions.
Heejin Bang, Mi-Sook Lee, Minjung Sung, Juyoung Choi, Sungbin An, Seok-Hyung Kim, Seung Eun Lee, Yoon-La Choi   +7 more
doaj   +1 more source

Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's disease.

, 2000
The neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 bind to the tyrosine kinase (trk) receptors trk A, trk B and trk C, respectively, with high affinity.
Savaskan E, Olivieri G, Rosenberg C, Hock C, Bruttel S, Otten U, Hulette C, Müller-Spahn F   +7 more
core   +1 more source

Unraveling the molecular mechanism of novel leukemia mutations on NTRK2 (A203T & R458G) and NTRK3 (E176D & L449F) genes using molecular dynamics simulations approach [version 2; peer review: 2 approved, 1 approved with reservations]

F1000Research
Background: NTRK1, NTRK2, and NTRK3 are members of the neurotrophic receptor tyrosine kinases (NTRK) family, which encode TrkA, TrkB, and TrkC receptors, respectively.
Fazil Ahmad, Khaldoon Alsamman, Abeer M Al-Subaie, Balu Kamaraj   +3 more
doaj   +1 more source

Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China

Thoracic Cancer, 2022
Gene fusions can drive tumor development for multiple types of cancer. Currently, many drugs targeting gene fusions are being approved for clinical application.
Chunwei Xu, Lu Si, Wenxian Wang, Ziming Li, Zhengbo Song, Qian Wang, Aijun Liu, Jinpu Yu, Wenfeng Fang, Wenzhao Zhong, Zhijie Wang, Yongchang Zhang, Jingjing Liu, Shirong Zhang, Xiuyu Cai, Anwen Liu, Wen Li, Ping Zhan, Hongbing Liu, Tangfeng Lv, Liyun Miao, Lingfeng Min, Yu Chen, Jingping Yuan, Feng Wang, Zhansheng Jiang, Gen Lin, Xingxiang Pu, Rongbo Lin, Weifeng Liu, Chuangzhou Rao, Dongqing Lv, Zongyang Yu, Lei Lei, Xiaoyan Li, Chuanhao Tang, Chengzhi Zhou, Junping Zhang, Junli Xue, Hui Guo, Qian Chu, Rui Meng, Jingxun Wu, Rui Zhang, Xiao Hu, Jin Zhou, Zhengfei Zhu, Yongheng Li, Hong Qiu, Fan Xia, Yuanyuan Lu, Xiaofeng Chen, Rui Ge, Enyong Dai, Yu Han, Weiwei Pan, Jiancheng Luo, Hongtao Jia, Xiaowei Dong, Fei Pang, Kai Wang, Liping Wang, Youcai Zhu, Yanru Xie, Xinqin Lin, Jing Cai, Jia Wei, Fen Lan, Huijing Feng, Lin Wang, Yingying Du, Wang Yao, Xuefei Shi, Xiaomin Niu, Dongmei Yuan, Yanwen Yao, Jianhui Huang, Yinbin Zhang, Pingli Sun, Hong Wang, Mingxiang Ye, Dong Wang, Zhaofeng Wang, Bing Wan, Donglai Lv, Qing Wei, Jin Kang, Jiatao Zhang, Chao Zhang, Genhua Yu, Juanjuan Ou, Lin Shi, Zhongwu Li, Zhefeng Liu, Jing Liu, Nong Yang, Lin Wu, Huijuan Wang, Gu Jin, Liu Yang, Guansong Wang, Meiyu Fang, Yong Fang, Yuan Li, Xiaojia Wang, Yiping Zhang, Shenglin Ma, Biyun Wang, Xiaotian Zhang, Yong Song, Yuanzhi Lu   +110 more
doaj   +1 more source

Involvement of TRK receptors in the nootropic effect of cycloprolylglycine

Фармакокинетика и Фармакодинамика
Background. The neuropeptide cycloprolylglycine (CPG) is an endogenous dipeptide analogue of the nootropic piracetam. It has been experimentally shown that CPG (designed and synthesized at the Federal State Budgetary Scientific Institution «Federal ...
O. N. Vorontsova, A. G. Alyaeva, K. N. Koliasnikova, P. Yu. Povarnina, T. A. Gudasheva, V. L. Dorofeev   +5 more
doaj   +1 more source

STAT3 activation by TRK oncogenes.

, 2013
(A) Western blot analysis of PC12 cells transfected with empty pRC/CMV vector, TRKA, TRK-T3, and TRK cDNAs. NGF treatment (50ng/ml, 10′) is indicated. Cell lysates and immunocomplexes were separated by SDS PAGE as described in Material and Methods and ...
Angela Greco (241294), Tiziana Fumagalli (366625), Maria Chiara Anania (366626), Sonia Pagliardini (366629), Claudia Miranda (241297), Maria Grazia Vizioli (366627), Marco A. Pierotti (241299)   +6 more
core   +1 more source

Neurotrophin and Trk expression by cells of the human lamina cribrosa following oxygen-glucose deprivation

BMC Neuroscience, 2004
Background Ischemia within the optic nerve head (ONH) may contribute to retinal ganglion cell (RGC) loss in primary open angle glaucoma (POAG). Ischemia has been reported to increase neurotrophin and high affinity Trk receptor expression by CNS neurons ...
Clark Abbot F, Lambert Wendi S, Wordinger Robert J   +2 more
doaj   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion–Positive Solid Tumors

, 2017
Larotrectinib, a selective TRK tyrosine kinase inhibitor (TKI), has demonstrated histology-agnostic efficacy in patients with TRK fusion–positive cancers.
Barry S. Taylor, Paul D. Larsen, Dorothea N. Douglas-Lindsay, Andrew Parker, Steve Andrews, Wen-I Wu, Kevin Ebata, Bethany Hanusch, Alexander Drilon, Shannon L. Winski, Paul R. Gordon, Ryma Benayed, Brian B. Tuch, David M. Hyman, Robyn Hamor, Nora Ku, Alison M. Schram, Steve Smith, Veronique Lauriault, Francis X. Sullivan, S. Michael Rothenberg, James F. Blake, Barbara J. Brandhuber, Lance A. Wollenberg, Ramamoorthy Nagasubramanian, Gabrielle R. Kolakowski, Maurizio Scaltriti, Tony H. Morales, Sandeep Raj, Philip Jonsson, Michael F. Berger, Karyn S. Bouhana, Walter E. DeWolf, Jaclyn F. Hechtman   +33 more
core   +1 more source