Results 21 to 30 of about 83,065 (165)
Revista del Instituto de Investigación de la Facultad de Minas, Metalurgia y Ciencias Geográficas, 2015 Con el objetivo de evaluar los peligros geológicos que afectan a la I.E.S. Ayusuma en la ladera del mismo nombre, distrito de Coasa, provincia Carabaya, región Puno, el día 20 de octubre del 2013 se inspeccionó la zona en compañía de los representantes ...
Norma Luz Sosa Senticala
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Diagnostics, 2022 ALK, NUT, and TRK are rare molecular aberrations that are pathognomonic for specific rare tumors. In low frequencies, however, they are found in a wide range of other tumor entities.
Marie-Isabelle Glückstein +7 more
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Frontiers in Oncology, 2023 NTRK fusions are validated oncogenic drivers of various adult and pediatric tumor types, including thyroid cancer, and serve as a therapeutic target. Recently, tropomyosin receptor kinase (TRK) inhibitors, such as entrectinib and larotrectinib, display ...
Qing-Xiang Yu +6 more
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On Trk for Retrograde Signaling [PDF]
, 2001 Target-derived neurotrophins like nerve growth factor (NGF) mediate biological effects by binding to and activating Trk neurotrophin receptors at nerve terminals. The activated Trk receptors then stimulate local effects at nerve terminals, and retrograde
Kaplan, David R, Miller, Freda D
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The Genomic and Proteomic Profiles of NTRK Genes and Trk Receptors in Liver Hepatocellular Carcinoma
Clinical Medicine Insights: Oncology, 2023 Background: The neurotrophic tyrosine kinase (NTRK) gene family includes NTRK1, NTRK2, and NTRK3, which encode tropomyosin receptor kinases TrkA, TrkB, and TrkC, respectively.
Hejing Wang +4 more
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NTRK Fusion in Non-Small Cell Lung Cancer: Diagnosis, Therapy, and TRK Inhibitor Resistance
Frontiers in Oncology, 2022 Neurotrophic tropomyosin receptor kinase (NTRK) gene fusion has been identified as an oncogenic driver of various solid tumors, and it is rare in non-smalll cell lung cancer (NSCLC) with a frequency of approximately less than 1%.
Fangfang Liu +5 more
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Analysis of trk A and p53 association [PDF]
, 2001 trk A tyrosine kinase (the high affinity receptor for nerve growth factor) binds to the p53 tumour suppressor protein in vitro and in vivo. Our aim was to determine which regions of p53 are involved in trk A association.
Rowe, Janice +7 more
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TRK Expression in Urothelial Bladder Cancer: A Single-center Cohort Study
Journal of Urological SurgeryObjective: Urothelial carcinoma is an aggressive malignancy with limited therapeutic options in the metastatic setting. Neurotrophic receptor tyrosine kinase (NTRK) gene fusions are actionable alterations in several solid tumors; however, their ...
Emre Akar +6 more
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Frontiers in Genetics, 2021 Bacteria use K+-uptake transporters differentially for adaptation in varying growth conditions. In Mycobacterium tuberculosis, two K+-uptake systems, the Trk comprising the CeoB and CeoC proteins and the Kdp consisting of the two-component system (TCS ...
Moloko C. Cholo +3 more
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Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies [PDF]
, 2018 Rearrangements involving the neurotrophic receptor kinase genes ( NTRK1, NTRK2, and NTRK3 ; hereafter referred to as TRK) produce oncogenic fusions in a wide variety of cancers in adults and children.
Scaltriti, Maurizio +53 more
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