Results 51 to 60 of about 83,065 (165)
EJNMMI Research, 2022 Background Tropomyosin receptor kinases (TrkA, TrkB, TrkC) are a family of tyrosine kinases primarily expressed in neuronal cells of the brain. Identification of oncogenic alterations in Trk expression as a driver in multiple tumor types has increased ...
Melinda Wuest +7 more
doaj +1 more source
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
New, potent, small molecule agonists of tyrosine kinase receptors attenuate dry eye disease
Frontiers in Medicine, 2022 Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin3 (NT-3) bind to tyrosine kinase (Trk) receptors, TrkA, TrkB, and TrkC, respectively. This study investigated the efficacy of novel molecule agonists of Trk receptors in
Zhiyuan Yu +5 more
doaj +1 more source
iNew Medicine, EarlyView.ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid +4 more
wiley +1 more source
Sprouty4 at the crossroads of Trk neurotrophin receptor signaling suppression by glucocorticoids
Frontiers in Molecular Neuroscience, 2023 Glucocorticoids (GC) affect neuronal plasticity, development and function of the nervous system by inhibiting neurotrophin-induced Trk signaling. It has been established that pretreatment with dexamethasone (DEX) restricts Neurotrophin-induced neurite ...
Facundo Ferrero Restelli +5 more
doaj +1 more source
Changes in Plasma TPH2, GDNF, Trk-b, BDNF, and proBDNF in People Who Died by Suicide
Brain Sciences, 2023 Recent studies have shown that neuropeptides and neurotrophic factors may be involved in the pathophysiological mechanisms of suicide. However, the current research on this aspect is still insufficient.
Xiaoyu Liu +4 more
doaj +1 more source
The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors
Medicinal Research Reviews, EarlyView.ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti +6 more
wiley +1 more source
İğsi hücreli mezenkimal tümörlerde pan-TRK ekspresyonu
, 2023 Amaç: Yumuşak doku tümörleri tanı koyması zor, nadir rastlanılan tümörlerdir. İğsi hücreli sarkomlarda NTRK füzyon geninin varlığı literatürde son yıllarda tespit edilmektedir.
SÜLEYMAN UYSAL
core
Radiopharmaceutical application of TRK-950, an anti-CAPRIN-1 therapeutic antibody
Journal of Cancer Research and Clinical OncologyPurpose Tumor imaging or therapy using cancer specific carriers combined with a radioisotope has huge potential. In radiopharmaceutical development, it is important to ensure target specificity and minimal binding to normal tissues for both tumor ...
Yuki Majima +7 more
doaj +1 more source
Small Methods, EarlyView.We developed a 3D‐printed nerve interface integrating a biomimetic nanocomposite hydrogel with sustained delivery of thermostable FGF‐2. The bioactive interface supports Schwann cell activity and myelination while providing a regenerative microenvironment.
Diego N. Rodriguez‐Sanchez +10 more
wiley +1 more source