Results 71 to 80 of about 83,065 (165)

Enzyme‐Digested Edible Bird's Nest Promotes NGF‐Induced Differentiation of PC12 Cells by Activating the TrkA‐ERK1/2‐CREB‐BDNF Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
EBND alone upregulates neurofilament expression but does not induce neurite outgrowth in PC12 cells. With suboptimal NGF, EBND synergistically promotes neuronal differentiation via the TrkA‐ERK1/2‐CREB‐BDNF pathway. This effect is blocked by the TrkA inhibitor GW441756, confirming a TrkA‐dependent mechanism.
Wen Zhang, Xintong Wang, Huiqing Zhu, Xiaoxian Lin, Rongzi Li, Man Yuan, Baocai Xu, Dongliang Wang, Wei Xiong, Yixuan Li   +9 more
wiley   +1 more source

Comparative Analysis of Profitability of Partnership Pattern of People's Sugarcane Credit (TRK) with Independent People's Sugarcane (TRM) (Case Study at PT. PG Rajawali II Sindanglaut Unit)

Indonesian Interdisciplinary Journal of Sharia Economics
This study aims to compare the profitability of the partnership pattern of People’s Sugarcane Credit (TRK) and Independent People’s Sugarcane (TRM) in PT. PG Rajawali II Sindanglaut Unit.
Muhammad Fazri, Iftitakhatur Rizqiyah, Bella Sukmarini, Akhmad Jaeroni, Tety Suciaty   +4 more
doaj   +1 more source

More Than a Birthmark? A Growing Pediatric Skin Lesion

JEADV Clinical Practice, EarlyView.
Shatha Ahmad Al Hajjaj, Sara Al Janahi, Shaden Abdelhadi   +2 more
wiley   +1 more source

Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies

MedComm, Volume 7, Issue 10, October 2026.
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao, Wenchao Xu, Yibo Wang, Haoran Huang, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +7 more
wiley   +1 more source

TRK Inhibition:A New Tumor-Agnostic Treatment Strategy [PDF]

, 2018
Oncogenic somatic chromosomal rearrangements involving the NTRK1, NTRK2 or NTRK3 genes (NTRK gene fusions) occur in up to 1% of all solid tumors, and have been reported across a wide range of tumor types.
Lassen, Ulrik N, Kummar, Shivaani
core   +1 more source

Colorectal Cancer: Epidemiology, Risk Factors, Signaling Pathways, Clinical Features, Screening, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
Colorectal cancer is a heterogeneous, adaptive disease shaped by population‐level risk, genomic and epigenetic alterations, tumor ecosystem evolution, and treatment pressure. This review integrates epidemiology, risk factors, signaling networks, clinical presentation, screening, molecular diagnosis, and stage‐ and biomarker‐guided management while ...
Kairui Wan, Ke Tang, Linglong Wang, Qin Tian, Mingwei Zheng, Cheng Qian, Limei Liu   +6 more
wiley   +1 more source

Abstract 16: Landscape and outcome of TRK fusion-positive Cancers

, 2020
TRK inhibitors achieve marked tumor-agnostic efficacy in TRK fusion-positive cancers and consequently are now an established standard of care. Little is known, however, about the demographics, clinical outcomes, response to alternative standard therapies,
Scaltriti, Maurizio, Ritika Kundra, Barry S. Taylor, Schram, Alison M., Sophie Shifman, James P. Solomon, Alberto Bardelli, Goldman, Debra A., Alexander Drilon, Ryma Benayed, David M. Hyman, Alison M. Schram, Drilon, Alexander, Hyman, David M., Solomon, James P., Debra A. Goldman, Shifman, Sophie, Kundra, Ritika, Bardelli, Alberto, Emiliano Cocco, Yixiao Gong, Benayed, Ryma, Maurizio Scaltriti, Iasonos, Alexia, Hechtman, Jaclyn F., Taylor, Barry S., Cocco, Emiliano, Gong, Yixiao, Ezra Y. Rosen, Alexia Iasonos, Rosen, Ezra Y., Jaclyn F. Hechtman   +31 more
core   +1 more source

Case Report: Novel findings of larotrectinib in children with NTRK-rearranged spindle cell tumor

Frontiers in Oncology
Neurotrophic tropomyosin receptor kinase (NTRK)-rearranged spindle cell tumors are often resistant to chemotherapy and radiotherapy. Fortunately, they are sensitive to targeted therapy of tropomyosin receptor kinase (TRK) inhibitors. However, the data on
Linnan Wu, Linnan Wu, Weiji Xie, Weiji Xie, Juan Wang, Juan Wang, Suying Lu, Suying Lu, Yizhuo Zhang, Yizhuo Zhang, Junting Huang, Junting Huang   +11 more
doaj   +1 more source

Trk retrograde signaling requires persistent, Pincher-directed endosomes

, 2010
Target-derived neurotrophins use retrogradely transported Trk-signaling endosomes to promote survival and neuronal phenotype at the soma. Despite their critical role in neurotrophin signaling, the nature and molecular composition of these endosomes ...
Wendy Akmentin, Howard J. Federoff, Simon Halegoua, Polyxeni Philippidou, Gregorio Valdez, William J. Bowers   +5 more
core   +1 more source

TRK‐immunoreactivity in the monkey central nervous system: Forebrain

, 1994
Neurotrophins such as nerve growth factor (NGF) mediate their effects through interactions with high‐affinity tropomycin‐related kinase (trk) receptors.
Jeffrey H. Kordower, Mufson, Elliott J., John R. Sladek, Kordower, Jeffrey H., Er‐Yun Chen, Chen, Er‐Yun ‐Y, Sladek, John R., Elliott J. Mufson   +7 more
core   +1 more source