Results 91 to 100 of about 83,065 (165)

Nuclear localization of TRK-A in liver cells [PDF]

, 2008
The liver represents a site of expression of neurotrophins and their receptors. We have characterized the expression and intracellular localization of the nerve growth factor (NGF) receptor, Trk-A, in liver cells in vivo and in vitro.
Rosini, Paolo, Torcia, María, Taddei, María Leticia, Marra, Fabio, Zecchi, Sandra, DeFranco, Raffaella, Milani, Stefano, Pinzani, Massimo, Bonacchi, Andrea, Formigli, Lucía, Rombouts, Krista, Petrai, LLaria, Laffi, Giacomo, Efsen, Eva, Nosi, Daniele   +14 more
core  

Trk C Signaling Is Required for Retinal Progenitor Cell Proliferation

, 2000
Although neurotrophin actions in the survival of specific retinal cell types have been identified, the biological functions for neurotrophin-3 (NT-3) in early retinal development remain unclear.
Evangeline Shih, Janet R. Sparrow, Takashi Mikawa, Barbara L. Hempstead, Indranil Das, Michelle I. Lin   +5 more
core   +1 more source

Human TRK proto-oncogene maps to chromosome 1q32-q41

, 1990
The chromosomal localization of TRK, a gene coding for a putative receptor molecule with an associated tyrosine kinase activity that we have found activated in 25% of patients with papillary thyroid carcinoma, was determined by Southern blot analysis of ...
M. A. Pierotti, G. Sozzi, M. Miozzo, P. Radice, G. Della Porta, I. Bongarzone, N. K. Spurr   +6 more
core   +2 more sources

The role of NTRK gene fusions in the biology and treatment of solid tumors

Oncology in Clinical Practice
NTRK gene fusions are rare but crucial oncogenic drivers across various solid tumors. They are more frequent in rare cancers, such as secretory carcinomas and found less commonly in common malignancies such as colorectal cancer, NSCLC, thyroid carcinoma,
Wojciech Kopyciński, Adrianna Baran, Maria Czerniawska, Olaf Krawczyk, Norbert Krawczyk, Sylwia Dębska-Szmich, Magdalena Krakowska   +6 more
doaj   +1 more source

Structural and dynamical properties of central nervous system proteins with pharmaceutical and biotechnological potential. [PDF]

, 2010
Neurodegenerative diseases are widespread pathologies of large social impact that include: prion, Alzheimer and Parkinson disease, Huntington chorea and amyotrophic lateral sclerosis.
Stanzione, Francesca
core  

Dramatic Responses Seen with TRK Inhibitor

, 2017
Presenting data on 50 of 55 patients with advanced TRK fusion–positive tumors, researchers reported that 76% of patients responded to the selective pan-TRK inhibitor larotrectinib, and 12% of patients experienced complete responses; 93% of responders ...

core   +1 more source

c-abl is involved in the association of p53 and trk A.

, 2000
The p53 tumour suppressor phosphoprotein associates with proteins involved in DNA replication, transcription, cell cycle machinery and regulation of its own expression.
Mitchell, Michael, Browes, Clare, Brown, Anna, Montano, Ximena   +3 more
core   +3 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio
Tropomyosin receptor kinase (Trk) receptors are essential regulators of neuronal development, survival, and plasticity through their interactions with neurotrophins.
Giray Enkavi
doaj   +1 more source

Belt drive construction improvement

Nauka ta progres transportu, 2012
The possibility of the traction capacity increase of the belt drive TRK is examined. This was done for the purpose of air conditioning system of passenger car with double-generator system energy supplying.
I.Yu. Khomenko
doaj  

Azaindole derivatives, Trk inhibitoring composition and pharmaceutical compositions for prevention and treatment of diseases linked to Trk comprising the same

, 2015
본 발명은 하기 [화학식 1]로 표시되는 아자인돌 유도체, 이를 포함하는 트로포미오신 관련 키나아제 (Tropomyosin-related kinase, Trk) 저해제 조성물 및 Trk와 연관된 질환의 예방과 치료에 사용되는 약학 조성물에 관한 것으로서, 본 발명에 따른 아자인돌 유도체 화합물 및 이의 약학적 수용 가능한 염은 Trk 저해제로서 Trk와 연관된 질환, 특히, 암 또는 통증성 질환 등을 치료하는 함암제 또는 통증완화제로 사용할 수 있다.[
홍승우, 서주현, 홍승희, 홍순선, 김진희   +4 more
core   +1 more source