Results 61 to 70 of about 83,065 (165)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

BPI-28592 as a novel second generation inhibitor for NTRK fusion tumors

npj Precision Oncology
Aberrant activation of tropomyosin receptor kinases (TRKs) is a well-defined oncogenic driver for neurotrophic tropomyosin receptor kinase (NTRK)-fusion cancers, and acquired resistant mutations have emerged with clinical use of the first-generation TRK ...
Jin Sheng, Hong Chen, Bang Fu, Hongming Pan, Jiabing Wang, Weidong Han   +5 more
doaj   +1 more source

Advances in 4D Representation: Geometry, Motion, and Interaction

Computer Graphics Forum, EarlyView.
We survey 4D representation through three key pillars — geometry, motion, and interaction — offering a selective, representation‐centric perspective to guide researchers in choosing and customizing the right 4D representation for their tasks. Abstract We present a survey on 4D generation and reconstruction, a fast‐evolving subfield of computer graphics
M. Zhao, S. Nag, K. Wang, A. Vora, G. Ji, P. Chun, A. Mahdavi‐Amiri, H. Zhang   +7 more
wiley   +1 more source

The significance of Trk receptors in pancreatic cancer

Tumor Biology, 2017
This study investigated the Trk receptor family as a therapeutic target in pancreatic ductal adenocarcinoma and assessed their prognostic significance.
Matthew D Johnson, Brandon Stone, Bryan J Thibodeau, Andrew M Baschnagel, Sandra Galoforo, Laura E Fortier, Billie Ketelsen, Samreen Ahmed, Zakiya Kelley, Alaa Hana, Thomas G Wilson, John M Robertson, Robert P Jury, George D Wilson   +13 more
doaj   +1 more source

PDGFD‐Rearranged Dermatofibrosarcoma Protuberans With S100 and Pan‐TRK Expression

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Dermatofibrosarcoma protuberans (DFSP) is a fibroblastic malignancy characterized in most cases by COL1A1::PDGFB fusion. Rare cases exhibit alternative rearrangements involving PDGFD. Here, we describe a female patient in her third decade of life who presented with a spindle cell proliferation on the shoulder.
Venezia Podesta, May P. Chan, Douglas Rottmann, Kelly L. Harms, Paul W. Harms   +4 more
wiley   +1 more source

Resistance to TRK inhibition mediated by convergent MAPK pathway activation

, 2019
TRK fusions are found in a variety of cancer types, lead to oncogenic addiction, and strongly predict tumor-agnostic efficacy of TRK inhibition(1-8). With the recent approval of the first selective TRK inhibitor, larotrectinib, for patients with any TRK ...
Toska, Eneda, Mattar, Marissa, Scaltriti, Maurizio, Marissa Mattar, Lanman, Richard B., Sophie Shifman, Selcuklu, S. Duygu, Tuch, Brian B., Kulick, Amanda, David M. Hyman, Brian Houck-Loomis, Ebata, Kevin, Houck-Loomis, Brian, Samoila, Aliaksandra, de Stanchina, Elisa, Hyman, David M., Somwar, Romel, Shifman, Sophie, Sean Guzman, Nagy, Rebecca J., Rebecca J. Nagy, Emiliano Cocco, Helen H. Won, Yaeger, Rona, S. Duygu Selçuklu, Eneda Toska, Hechtman, Jaclyn F., Michael F. Berger, Jaclyn F. Hechtman, Richard B. Lanman, Juber A. Patel, Marc Ladanyi, Sandra Misale, Rona Yaeger, Aliaksandra Samoila, Schram, Alison M., Amanda Kulick, Romel Somwar, Kevin Ebata, Alexander Drilon, Brian B. Tuch, Alison M. Schram, Cownie, James, Berger, Michael F., Drilon, Alexander, Misale, Sandra, Ryan Ptashkin, James Cownie, Razavi, Pedram, Ladanyi, Marc, Maurizio Scaltriti, Won, Helen H., Cocco, Emiliano, Ptashkin, Ryan, Guzman, Sean, Patel, Juber A., Pedram Razavi, Elisa de Stanchina   +57 more
core   +1 more source

Neurocardiac crosstalk in inherited cardiac arrhythmias and cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend In inherited cardiac arrhythmias and cardiomyopathy, arrhythmias are typically triggered by autonomic nervous system activity. Genetic mutations linked to these conditions cause pro‐arrhythmic alterations in both cardiomyocytes and neurons, with their pathophysiological crosstalk likely amplifying the manifestation of the disease.
Carol Ann Remme, Molly O'Reilly
wiley   +1 more source

NTRK amplification occurs frequently in pan-TRK immunopositive dedifferentiated liposarcomas

Pathology and Oncology Research
The neurotrophic tyrosine kinase receptor (NTRK) gene family is of rising importance as their fusions are oncogenic, and specific target drugs are available to inhibit the chimera proteins.
Zoltán Lippai, Gergő Papp, Károly Szuhai, Johanna Sápi, Katalin Dezső, Zoltán Sápi   +5 more
doaj   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Adolescent Ethanol Exposure Disrupts the Mature Phenotype of Surviving Neuroprogenitors in Female Mice

Hippocampus, Volume 36, Issue 6, November 2026.
ABSTRACT Rodent models of human adolescent binge drinking persistently reduce adult neurogenesis and induce innate immune signaling cascades, suggesting long‐lasting dysfunction in the hippocampal neurogenic niche. Nevertheless, many neuroprogenitors survive, and the impact of adolescent ethanol on the mature phenotype of these surviving neurons is ...
Kaitlyn Campbell, Madison McDowell, Eymani Alston, Hunter Kelley, Michael Kasten, Paul B. Manis, Fulton Crews, Victoria Macht   +7 more
wiley   +1 more source