Results 111 to 120 of about 2,911,119 (244)

Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus [PDF]

Neuropharmacology, 2011
Acetylcholinesterase inhibitors are first-line therapies for Alzheimer's disease. These drugs increase cholinergic tone in the target areas of the cholinergic neurons of the basal forebrain. Basal forebrain cholinergic neurons are dependent upon trophic support by nerve growth factor (NGF) through its neurotrophin receptor, TrkA.
Henri, Autio, Kert, Mätlik, Tomi, Rantamäki, Lothar, Lindemann, Marius C, Hoener, Moses, Chao, Urmas, Arumäe, Eero, Castrén   +7 more
openaire   +3 more sources

Bacterial Toxin Exploits Host Membrane Phospholipid as a Receptor for Binding, Entry, and Cytopathogenicity

Molecular Microbiology, Volume 125, Issue 2, Page 145-158, February 2026.
Mycoplasma pneumoniae pathogenesis relies on its CARDS toxin, which initiates cell binding and subsequent uptake by exploiting sphingomyelin, a key phospholipid found in the host plasma membrane. Maximal cellular entry and full cytotoxic effects are achieved through a synergistic mechanism that involves interaction with the protein coreceptor annexin ...
Alejandra M. Kirkpatrick, Thirumalai R. Kannan   +1 more
wiley   +1 more source

Role of neurotrophins on dermal fibroblast survival and differentiation [PDF]

, 2011
Neurotrophins (NTs) belong to a family of growth factors that play a critical role in the control of skin homeostasis. NTs act through the low-affinity receptor p75NTR and the high-affinity receptors TrkA, TrkB and TrkC.
Dallaglio, Katiuscia, E., Perrier, M., Dumas, Marconi, Alessandra, P., Humbert, Palazzo, Elisabetta, Petrachi, Tiziana, Pincelli, Carlo, S., Schnebert, Truzzi, Francesca   +9 more
core   +3 more sources

High‐Throughput 3D Glioblastoma Model in Glycosaminoglycan Hydrogels for Personalized Therapeutic Screening

Macromolecular Bioscience, Volume 26, Issue 1, January 2026.
Kaur–Trautmann et al. present a high‐throughput, chemically defined 3D glioblastoma model based on glycosaminoglycan hydrogels that allow orthogonal control of stiffness, adhesion, and degradability while standardizing soluble‐factor presentation. The platform supports automated imaging and transcriptomic profiling, enabling patient‐specific drug ...
Rajvinder Kaur Trautmann, Nicholas Dennison, Kathleen McCortney, Solveig Klier, Mehmet Ilyas Cosacak, Carsten Werner, Goktug Akyoldas, Craig M. Horbinski, Uwe Freudenberg, Caghan Kizil   +9 more
wiley   +1 more source

Plant‐Derived Viral Nanoparticles Enable Simultaneous Guidance of Neuronal Cell Outgrowth and Targeting of Neurodifferentiation Pathways

Small, Volume 22, Issue 1, 2 January 2026.
A neuronal tissue engineering approach employing plant‐derived viral nanoparticles (VNPs) that have been genetically engineered to display functional peptides is presented. These VNPs simultaneously promote neuronal differentiation and directional growth.
Mira Ritter, Natalija Stojanović, Simon Zschieschang, Johannes Grader, MHD Naeem Assasa, Eva Miriam Buhl, Andrea Coschiera, Stefan Schillberg, Juliane Schuphan, Horst Fischer   +9 more
wiley   +1 more source

NTRK-fused central nervous system tumours: clinicopathological and genetic insights and response to TRK inhibitors

Acta Neuropathologica Communications
Background Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are found in 1% of gliomas across children and adults. TRK inhibitors are promising therapeutic agents for NTRK-fused gliomas because they are tissue agnostic and cross the blood ...
Eric Eunshik Kim, Chul-Kee Park, Seung-Ki Kim, Ji Hoon Phi, Sun Ha Paek, Jung Yoon Choi, Hyoung Jin Kang, Joo Ho Lee, Jae Kyung Won, Hongseok Yun, Sung-Hye Park   +10 more
doaj   +1 more source

LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response [PDF]

, 2016
LDL receptor-related protein-1 (LRP1) is an endocytic and cell-signaling receptor. In mice in which LRP1 is deleted in myeloid cells, the response to lipopolysaccharide (LPS) was greatly exacerbated.
Azmoon, Pardis, Brifault, Coralie, Gilder, Andrew S, Gonias, Steven L., Lam, Michael S, Mantuano, Elisabetta   +5 more
core   +1 more source

Comparative Analysis of a Dual DNA–RNA Panel and a DNA‐Only Panel for Sarcoma: Real‐World Data From a Nationwide Genomic Database

Cancer Science, Volume 117, Issue 1, Page 156-168, January 2026.
Dual DNA–RNA panel with matched tumor–normal testing may improve diagnostic accuracy and inform treatment decisions in the routine clinical management of sarcoma. ABSTRACT Next‐generation sequencing‐based comprehensive cancer genomic profiling is promising in cancer management; however, most studies rely on tumor‐only DNA panels from single ...
Eiji Nakata, Kiichiro Ninomiya, Tatsunori Osone, Daisuke Ennishi, Shuta Tomida, Tomohiro Fujiwara, Toshiyuki Kunisada, Mashu Futagawa, Akira Hirasawa, Shinichi Toyooka, Toshifumi Ozaki   +10 more
wiley   +1 more source

Yifei Decoction Regulates the NGF/TRKA/PI3K/AKT Signaling Axis to Inhibit the Epithelial–Mesenchymal Transformation and Proliferation of Pulmonary Epithelial Cells in Bleomycin‐Induced Pulmonary Fibrogenesis

Canadian Respiratory Journal, Volume 2026, Issue 1, 2026.
Background It was important to find better therapeutic drugs for idiopathic pulmonary fibrosis (IPF), and in our previous study, Yifei decoction (YFT) alleviated IPF. A deeper understanding of its mechanisms of action could aid in the development of novel treatment strategies.
Lijuan Chen, Chengzhong Lan, Xiangli Deng, Mei Wu, Mei Shao, Mei Yang, Xinwen Ma, Fen Huang, Haiyin Wu, Lipi Buch   +9 more
wiley   +1 more source

Nerve growth factor promotes the proliferation of Müller cells co-cultured with internal limiting membrane by regulating cell cycle via Trk-A/PI3K/Akt pathway

BMC Ophthalmology, 2019
Background Nerve growth factor (NGF), produced by Müller cells, and internal limiting membrane (ILM) have fundamental roles in the development of full-thickness macular hole (FTMH). However, the potential crosstalk between NGF and ILM in FTMH is unclear.
Luyi Zhang, Xiaoxia Li, Xiaoqin Lin, Miaoqin Wu   +3 more
doaj   +1 more source