Results 91 to 100 of about 681,398 (156)

A Modified Chinese Herbal Decoction (Kai-Xin-San) Promotes NGF-Induced Neuronal Differentiation in PC12 Cells via Up-Regulating Trk A Signaling

Frontiers in Cell and Developmental Biology, 2017
Kai-Xin-San (KXS), a Chinese herbal decoction, has been applied to medical care of depression for thousands of years. It is composed of two functional paired-herbs: Ginseng Radix et Rhizoma (GR)-Polygalae Radix (PR) and Acori Tatarinowii Rhizoma (ATR ...
Lu Yan, Lu Yan, Lu Yan, Lu Yan, Min Wei, Min Wei, Amy G. Gong, Amy G. Gong, Pingping Song, Pingping Song, Jianshu Lou, Jianshu Lou, Cathy W. Bi, Cathy W. Bi, Sherry L. Xu, Aizhen Xiong, Tina T. Dong, Tina T. Dong, Karl W. Tsim, Karl W. Tsim   +19 more
doaj   +1 more source

Sustained response to larotrectinib in a pediatric patient with recurrent STRN3::NTRK2 fusion-positive pilocytic astrocytoma

CNS Oncology
A 7-year-old female with recurrent midline pilocytic astrocytoma harboring a rare STRN3::NTRK2 fusion achieved sustained near-complete radiographic and clinical response to larotrectinib, a selective TRK inhibitor.
Kishore Balasubramanian, Kar-Ming Fung, Rene Y. McNall-Knapp, Karl Balsara   +3 more
doaj   +1 more source

Influence of brain-derived neurotrophic factor on pathfinding of dentate granule cell axons, the hippocampal mossy fibers

Molecular Brain, 2009
Mossy fibers, the dentate granule cell axons, are generated throughout an animal's lifetime. Mossy fiber paths and synapses are primarily restricted to the stratum lucidum within the CA3 region.
Tamura Makoto, Tamura Naohiro, Ikeda Takamitsu, Koyama Ryuta, Ikegaya Yuji, Matsuki Norio, Yamada Maki K   +6 more
doaj   +1 more source

Abstract 3168: Overcoming acquired drug resistance by TPX-0005, an ALK, ROS1 and pan-TRK inhibitor

, 2017
The inevitable development of clinical drug resistance presents a common challenge for targeted cancer therapy. In non-small cell lung cancer (NSCLC) patients with ALK and ROS1 rearrangements, the emergence of mutations in the targeted oncogenes was ...
Evan Rogers, Wei Deng, Dayong Zhai, John Huang, Jean Cui   +4 more
core   +1 more source

RET receptor expression and interaction with TRK receptors in neuroblastomas

, 2020
Neuroblastomas (NBs) have heterogeneous clinical behavior, from spontaneous regression or differentiation to relentless progression. Evidence from our laboratory and others suggests that neurotrophin receptors contribute to these disparate behaviors ...
Tetri, Laura H., Macfarland, Suzanne P., Naraparaju, Koumudi, Choi, Jee-Hye, Nguyen, Ferro, Kolla, Venkatadri, Golden, Rebecca L., Brodeur, Garrett M., Gaonkar, Krutika S., Croucher, Jamie L., Iyer, Radhika, Raman, Pichai, Guan, Peng   +12 more
core   +1 more source

Case report: Complete and durable response to larotrectinib (TRK inhibitor) in an infant diagnosed with angiosarcoma harbouring a KHDRBS1-NTRK3 fusion gene. [PDF]

Front Oncol, 2023
Cervi C, Sápi Z, Bedics G, Zajta E, Hegyi L, Pápay J, Dezső K, Varga E, Mudra K, Bödör C, Csóka M.   +10 more
europepmc   +1 more source

Sigma-1 receptor enhances neurite elongation of cerebellar granule neurons via TrkB signaling.

PLoS ONE, 2013
Sigma-1 receptor (Sig-1R) is an integral membrane protein predominantly expressed in the endoplasmic reticulum. Sig-1R demonstrates a high affinity to various synthetic compounds including well-known psychotherapeutic drugs in the central nervous system (
Yuriko Kimura, Yuki Fujita, Kumi Shibata, Megumi Mori, Toshihide Yamashita   +4 more
doaj   +1 more source

High prevalence of NTRK fusions in sporadic dMMR/MSI mCRC RAS/RAF wild-type: an opportunity for a post-immune checkpoint inhibitors progression rescue strategy

ESMO Gastrointestinal Oncology
Background: Currently, mismatch repair deficient/microsatellite instable (dMMR/MSI) status constitutes a validated predictive marker of response to immune checkpoint inhibitors (ICIs) in patients with metastatic colorectal cancer (mCRC).
M. Svrcek, A. Cayre, T. Samaille, R. Colle, L. Mas, P. Bourgoin, E. Guillerm, R. Cohen, F. Penault-Llorca, T. André, N. Radosevic-Robin   +10 more
doaj   +1 more source

Discovery of a rare GKAP1-NTRK2 fusion in a pediatric low-grade glioma, leading to targeted treatment with TRK-inhibitor larotrectinib. [PDF]

Cancer Biol Ther, 2021
Deland L, Keane S, Olsson Bontell T, Sjögren H, Fagman H, Øra I, De La Cuesta E, Tisell M, Nilsson JA, Ejeskär K, Sabel M, Abel F.   +11 more
europepmc   +1 more source

Larotrectinib in NTRK3 fusion–positive metastatic secretory carcinoma of the breast: A case study

Current Problems in Cancer: Case Reports
Triple-negative breast cancer (TNBC) is an aggressive heterogeneous form of breast cancer that accounts for 15 %-20 % of all breast cancers. Characterized by an absence of estrogen receptor, progesterone receptor, and human epidermal growth factor ...
Martin Dietrich, Michel Velez
doaj   +1 more source