Results 71 to 80 of about 681,398 (156)

Supplementary Methods, References, Figures 1-4, Tables 1-3 from A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion–Positive Solid Tumors

, 2017
Supplementary Methods Supplementary References Supplementary Figure 1. Effect of acquired resistance mutations on TRK inhibitor activity. Supplementary Figure 2.
Steve Smith (55013), Karyn S. Bouhana (15104134), Michael F. Berger (10901771), Dorothea N. Douglas-Lindsay (15104149), Maurizio Scaltriti (8409741), Brian B. Tuch (14771377), Gabrielle R. Kolakowski (15104128), Jaclyn F. Hechtman (14928668), Shannon L. Winski (14879886), David M. Hyman (14928665), Sandeep Raj (15104152), Barbara J. Brandhuber (241265), Steve Andrews (12302423), Ramamoorthy Nagasubramanian (15104119), Lance A. Wollenberg (15104143), Veronique Lauriault (15104125), Tony H. Morales (15104140), Barry S. Taylor (8595927), Wen-I Wu (241252), Philip Jonsson (179685), Francis X. Sullivan (8677611), Robyn Hamor (15104137), Ryma Benayed (4037909), Paul D. Larsen (15104131), Walter E. DeWolf (1706491), Alexander Drilon (14991519), Andrew Parker (133739), James F. Blake (2039950), Kevin Ebata (4244284), Nora Ku (15104122), Bethany Hanusch (15104155), Alison M. Schram (3772174), S. Michael Rothenberg (14900778), Paul R. Gordon (15104146)   +33 more
core   +1 more source

Efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma [PDF]

, 2022
Objective: Larotrectinib is a highly selective tropomyosin receptor kinase (TRK) inhibitor with demonstrated efficacy across various TRK fusion-positive solid tumours.
Brega, Nicoletta, Sherman, Eric, Oh, Do-Youn, Bauman, Jessica, Brose, Marcia S, Almubarak, Mohammed, Drilon, Alexander, Krishnamurthy, Anuradha, Hong, David S, Norenberg, Ricarda, Cabanillas, Maria E, Casanova, Michela, Waguespack, Steven G, Silvertown, Josh D, Lin, Jessica J, Sohal, Davendra, Park, Keunchil, Leyvraz, Serge, McDermott, Ray, Kummar, Shivaani   +19 more
core   +1 more source

More Than a Birthmark? A Growing Pediatric Skin Lesion

JEADV Clinical Practice, EarlyView.
Shatha Ahmad Al Hajjaj, Sara Al Janahi, Shaden Abdelhadi   +2 more
wiley   +1 more source

Immunological Features of Neuroendocrine Neoplasms and Adrenal Tumors

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Neuroendocrine neoplasms, which occur throughout the human body, as well as adrenocortical carcinoma and pheochromocytoma, which originate in the adrenal gland, are primarily classified as rare malignancies. Immunotherapy, including immune checkpoint inhibitors (ICIs), is generally not incorporated into the standard care protocols for these ...
Akihiro Ohmoto, Shunji Takahashi, Shigehisa Kitano   +2 more
wiley   +1 more source

Resistance to TRK inhibition mediated by convergent MAPK pathway activation

, 2019
TRK fusions are found in a variety of cancer types, lead to oncogenic addiction, and strongly predict tumor-agnostic efficacy of TRK inhibition(1-8). With the recent approval of the first selective TRK inhibitor, larotrectinib, for patients with any TRK ...
Toska, Eneda, Mattar, Marissa, Scaltriti, Maurizio, Marissa Mattar, Lanman, Richard B., Sophie Shifman, Selcuklu, S. Duygu, Tuch, Brian B., Kulick, Amanda, David M. Hyman, Brian Houck-Loomis, Ebata, Kevin, Houck-Loomis, Brian, Samoila, Aliaksandra, de Stanchina, Elisa, Hyman, David M., Somwar, Romel, Shifman, Sophie, Sean Guzman, Nagy, Rebecca J., Rebecca J. Nagy, Emiliano Cocco, Helen H. Won, Yaeger, Rona, S. Duygu Selçuklu, Eneda Toska, Hechtman, Jaclyn F., Michael F. Berger, Jaclyn F. Hechtman, Richard B. Lanman, Juber A. Patel, Marc Ladanyi, Sandra Misale, Rona Yaeger, Aliaksandra Samoila, Schram, Alison M., Amanda Kulick, Romel Somwar, Kevin Ebata, Alexander Drilon, Brian B. Tuch, Alison M. Schram, Cownie, James, Berger, Michael F., Drilon, Alexander, Misale, Sandra, Ryan Ptashkin, James Cownie, Razavi, Pedram, Ladanyi, Marc, Maurizio Scaltriti, Won, Helen H., Cocco, Emiliano, Ptashkin, Ryan, Guzman, Sean, Patel, Juber A., Pedram Razavi, Elisa de Stanchina   +57 more
core   +1 more source

NTRK-fused central nervous system tumours: clinicopathological and genetic insights and response to TRK inhibitors

Acta Neuropathologica Communications
Background Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are found in 1% of gliomas across children and adults. TRK inhibitors are promising therapeutic agents for NTRK-fused gliomas because they are tissue agnostic and cross the blood ...
Eric Eunshik Kim, Chul-Kee Park, Seung-Ki Kim, Ji Hoon Phi, Sun Ha Paek, Jung Yoon Choi, Hyoung Jin Kang, Joo Ho Lee, Jae Kyung Won, Hongseok Yun, Sung-Hye Park   +10 more
doaj   +1 more source

Precision Medicine for Pediatric Glioma and NF1-Associated Tumors: The Role of Small Molecule Inhibitors

Current Oncology
Pediatric gliomas encompass the most common brain tumor in children and are subdivided into pediatric low-grade gliomas (pLGGs) and pediatric high-grade gliomas (pHGGs). The era of molecular diagnosis has shifted the treatment paradigms and management of
Samuele Renzi, Julie Bennett, Nirav Thacker, Chantel Cacciotti   +3 more
doaj   +1 more source

Clinical Outcomes, Treatment Patterns, and Molecular Heterogeneity of TFE3‐Rearranged Renal Cell Carcinoma: A Multicenter Real‐World Study

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Background TFE3‐rearranged renal cell carcinoma (TFE3‐rRCC) is uncommon and encompasses biologically diverse tumors, while evidence to guide systemic treatment remains sparse. We examined clinical outcomes, treatment patterns, and molecular features in a multicenter real‐world cohort.
Shuxuan Zhu, Siqi Zhou, Xi Tian, Jun Wang, Ze Wang, Jun Jiang, Qiuli Liu, Xin Gou, Xiang Zhou, Jun Gu, Jianfeng Yang, Jianhui Chen, Shushang Chen, Wenfeng Wang, Aihetaimujiang Anwaier, Kun Chang, Yuanyuan Qu, James Brugarolas, Wenhao Xu, Hailiang Zhang, Dingwei Ye   +20 more
wiley   +1 more source

Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's disease.

, 2000
The neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 bind to the tyrosine kinase (trk) receptors trk A, trk B and trk C, respectively, with high affinity.
Savaskan E, Olivieri G, Rosenberg C, Hock C, Bruttel S, Otten U, Hulette C, Müller-Spahn F   +7 more
core   +1 more source

Schwann Cells in Physical Nerve Injury and Tumor Perineural Invasion: A Functional Overview and Comparison

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT The nervous system exhibits remarkable stability, making its repair challenging. Compared to the central nervous system, peripheral nerve injuries demonstrate a greater potential for regeneration. Schwann cells, the unique myelinating glial cells of the peripheral nervous system, possess striking plasticity and support nerve regeneration ...
Yanni Zheng, Xin Chen, Jiachen Liu, Jiayi Chen, Lei Tang, Wenjun Liu, Yuxin Lin, Xuedong Wei   +7 more
wiley   +1 more source