Results 81 to 90 of about 681,398 (156)

The efficacy of larotrectinib (LOXO-101), a selective tropomyosin receptor kinase (TRK) inhibitor, in adult and pediatric TRK fusion cancers.

, 2017
LBA2501 Background: Larotrectinib is the first selective small-molecule pan-TRK inhibitor. TRK fusions appear oncogenic independent of tumor lineage, are widely distributed across cancers, and affect all ages.
Wafik S. El-Deiry, Nora C. Ku, Douglas S. Hawkins, Ulrik Niels Lassen, Valentina Boni, Steven G. DuBois, George D. Demetri, David S. Hong, Brian Turpin, Theodore Willis Laetsch, Afshin Dowlati, David Michael Hyman, Ramamoorthy Nagasubramanian, Alexander E. Drilon, Anna F. Farago, Marcia S. Brose, Scott Cruickshank, Michael Craig Cox, Shivaani Kummar, Alberto S. Pappo   +19 more
core   +1 more source

Crosstalk Between Cortical Plasticity and Peripheral Nervous Injury: Insights, Mechanisms, and Future Directions

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Peripheral nerve injury induces dynamic cortical plasticity, driven by molecular mechanisms such as BDNF and neurotransmitter systems. This review synthesizes subtype‐specific plasticity patterns: compressive injuries trigger rapid reorganization, while metabolic neuropathies lead to maladaptive changes.
Cong Cheng, Dong Gao, Yaojie Shen, Xi Wang, Junxi Dai, Yaoxian Xiang, Zongyuan Jiang, Zongqi You, Junjian Jiang   +8 more
wiley   +1 more source

Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models

, 2016
Neurotrophins and their receptors (TRKs) play key roles in the development of the nervous system and the maintenance of the neural network. Accumulating evidence points to their role in malignant transformations, chemotaxis, metastasis, and survival ...
Yi Fan (285912), Fangxian Sun (1601665), Yelena Sarkisova (2115442), Valentina Molteni (772022), Pam Albaugh (2115433), Zuosheng Liu (2115439), Tove Tuntland (1285806), Min Lu (238723), Shenlin Huang (1634971), Nanxin Li (672564), Andreas Kreusch (1601689), Tami Hood (1601692), Donald S. Karanewsky (2115436), Yong Jia (1601683), Yuan Mi (1982059), Guoxun Liu (1601656), Francisco Adrian (1601695), Jon Loren (1601662), H. Martin Seidel (762811)   +18 more
core   +1 more source

Nerve growth factor promotes the proliferation of Müller cells co-cultured with internal limiting membrane by regulating cell cycle via Trk-A/PI3K/Akt pathway

BMC Ophthalmology, 2019
Background Nerve growth factor (NGF), produced by Müller cells, and internal limiting membrane (ILM) have fundamental roles in the development of full-thickness macular hole (FTMH). However, the potential crosstalk between NGF and ILM in FTMH is unclear.
Luyi Zhang, Xiaoxia Li, Xiaoqin Lin, Miaoqin Wu   +3 more
doaj   +1 more source

Supplementary Table S1 from Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway

, 2009
Supplementary Table S1 from Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase ...
Kenneth Thress (2044987), Ethan Hoffmann (1613374), Zhong-Ying Liu (2044975), Tao Wang (12008), Haiyun Wang (27725), Kevin Webster (15042242), Lizhi Zeng (15042245), Peter E. Zage (12199349), Terry MacIntyre (1864681), Patrick A. Zweidler-McKay (14974308), Dave Whitston (15042239), Charles Omer (1981468), Jeffrey L. Brown (14981387)   +12 more
core   +1 more source

The landscape of cancer-associated transcript fusions in adult brain tumors: a longitudinal assessment in 140 patients with cerebral gliomas and brain metastases

Frontiers in Oncology
BackgroundOncogenic fusions of neurotrophic receptor tyrosine kinase NTRK1, NTRK2, or NTRK3 genes have been found in different types of solid tumors.
Philippe Metellus, Philippe Metellus, Clara Camilla, Clara Camilla, Emilie Bialecki, Nathalie Beaufils, Christine Vellutini, Eric Pellegrino, Pascale Tomasini, Pascale Tomasini, Manmeet S. Ahluwalia, Manmeet S. Ahluwalia, Alireza Mansouri, Isabelle Nanni, L’Houcine Ouafik, L’Houcine Ouafik   +15 more
doaj   +1 more source

Supplementary Table S2 from Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway

, 2009
Supplementary Table S2 from Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase ...
Kenneth Thress (2044987), Ethan Hoffmann (1613374), Zhong-Ying Liu (2044975), Tao Wang (12008), Haiyun Wang (27725), Kevin Webster (15042242), Lizhi Zeng (15042245), Peter E. Zage (12199349), Terry MacIntyre (1864681), Patrick A. Zweidler-McKay (14974308), Dave Whitston (15042239), Charles Omer (1981468), Jeffrey L. Brown (14981387)   +12 more
core   +1 more source

NTRK1-rearranged histiocytosis: clinicopathologic and molecular features

Blood Advances
: Non-Langerhans cell histiocytoses are a diverse group of histiocytic diseases. Different entities are defined based on clinical, histopathologic, and/or molecular characteristics. This study aimed to define NTRK-rearranged histiocytosis.
Rivers Fragneau, Sylvie Fraitag, Paul G. Kemps, Zofia Hélias-Rodzewicz, Somak Roy, Benjamin Bonsang, Allison L. Bartlett, Subhra Dhar, Martin Jankofsky, Jozef Zlocha, Karel Svojgr, Lenka Krsková, Andrica C. H. de Vries, Robert M. Verdijk, Jan A. M. van Laar, Roos J. Leguit, Philippe Drabent, Eric D. Carlsen, Jonhan Ho, Arivarasan D. Karunamurthy, Mariarita Santi, Marie-Laure Jullié, Florian Babor, Robert Lorsbach, Astrid G. S. van Halteren, Sébastien Héritier, Eli L. Diamond, Benjamin H. Durham, Ashish R. Kumar, Arunaloke Bhattacharya, Julien Haroche, Jean Donadieu, Arndt Borkhardt, Jennifer L. Picarsic, Jean-François Emile   +34 more
doaj   +1 more source

Antitumor Activity of Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor, in ETV6-NTRK3–Positive Acute Myeloid Leukemia

, 2018
Activation of tropomyosin receptor kinase (TRK) family tyrosine kinases by chromosomal rearrangement has been shown to drive a wide range of solid tumors and hematologic malignancies.
Colin Walsh, Elena Pomari, Paolo Bonvini, Gang Li, Kristen M. Smith, Chiara Frasson, Patrick C. Fagan, Giuseppe Germano, Ian Silverman   +8 more
core   +1 more source

Limb salvage of an infant with infantile fibrosarcoma using TRK inhibitor larotrectinib. [PDF]

Ecancermedicalscience, 2023
Sahni S, Rastogi S, Yadav R, Barwad A.
europepmc   +1 more source