Results 61 to 70 of about 681,398 (156)

Neurocardiac crosstalk in inherited cardiac arrhythmias and cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend In inherited cardiac arrhythmias and cardiomyopathy, arrhythmias are typically triggered by autonomic nervous system activity. Genetic mutations linked to these conditions cause pro‐arrhythmic alterations in both cardiomyocytes and neurons, with their pathophysiological crosstalk likely amplifying the manifestation of the disease.
Carol Ann Remme, Molly O'Reilly
wiley   +1 more source

Acquired resistance to the TRK inhibitor entrectinib in colorectal cancer [PDF]

, 2016
Entrectinib is a first-in-class pan-TRK kinase inhibitor currently undergoing clinical testing in colorectal cancer and other tumor types. A patient with metastatic colorectal cancer harboring an LMNA-NTRK1 rearrangement displayed a remarkable response ...
Misale, Sandra, L. Novara, M. Russo, S. Siena, Rospo, Giuseppe, G. Crisafulli, R. Wild, R. Patel, A. Bartolini, Lazzari, Luca, Di Nicolantonio, Federica, G. Corti, S. Misale, Russo, Mariangela, S. Yan, N. Cam, G. Wei, F. Di Nicolantonio, R. Shoemaker, Siravegna, Giulia, A. Sartore Bianchi, L. Lazzari, G. Li, Crisafulli, Giovanni, B. Mussolin, Bardelli, Alberto, G. Rospo, G. Siravegna, A. Bardelli   +28 more
core   +1 more source

Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism

Neurobiology of Disease, 2007
The anti-Parkinson monoamine oxidase (MAO)-B inhibitor rasagiline (Azilect) was shown to possess neuroprotective activities, involving the induction of brain-derived- and glial cell line-derived neurotrophic factors (BDNF, GDNF).
Yotam Sagi, Silvia Mandel, Tamar Amit, Moussa B.H. Youdim   +3 more
doaj   +1 more source

Adolescent Ethanol Exposure Disrupts the Mature Phenotype of Surviving Neuroprogenitors in Female Mice

Hippocampus, Volume 36, Issue 6, November 2026.
ABSTRACT Rodent models of human adolescent binge drinking persistently reduce adult neurogenesis and induce innate immune signaling cascades, suggesting long‐lasting dysfunction in the hippocampal neurogenic niche. Nevertheless, many neuroprogenitors survive, and the impact of adolescent ethanol on the mature phenotype of these surviving neurons is ...
Kaitlyn Campbell, Madison McDowell, Eymani Alston, Hunter Kelley, Michael Kasten, Paul B. Manis, Fulton Crews, Victoria Macht   +7 more
wiley   +1 more source

TRK Inhibition:A New Tumor-Agnostic Treatment Strategy [PDF]

, 2018
Oncogenic somatic chromosomal rearrangements involving the NTRK1, NTRK2 or NTRK3 genes (NTRK gene fusions) occur in up to 1% of all solid tumors, and have been reported across a wide range of tumor types.
Lassen, Ulrik N, Kummar, Shivaani
core   +1 more source

Supplementary Fig. S3 from Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway

, 2009
Supplementary Fig. S3 from Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase ...
Kenneth Thress (2044987), Ethan Hoffmann (1613374), Zhong-Ying Liu (2044975), Tao Wang (12008), Haiyun Wang (27725), Kevin Webster (15042242), Lizhi Zeng (15042245), Peter E. Zage (12199349), Terry MacIntyre (1864681), Patrick A. Zweidler-McKay (14974308), Dave Whitston (15042239), Charles Omer (1981468), Jeffrey L. Brown (14981387)   +12 more
core   +2 more sources

Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies

MedComm, Volume 7, Issue 10, October 2026.
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao, Wenchao Xu, Yibo Wang, Haoran Huang, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +7 more
wiley   +1 more source

Identification of 4-Aminopyrazolylpyrimidines as Potent Inhibitors of Trk Kinases

, 2016
The design, synthesis and biological evaluation of a series of 4-aminopyrazolylpyrimidines as potent Trk kinase inhibitors is reported. High-throughput screening identified a promising hit in the 4-aminopyrazolylpyrimidine chemotype. Initial optimization
Michelle L. Lamb (1545151), John W. Lee (2094133), Ethan Hoffmann (1613374), Ken Thress (2425075), Dingwei Yu (2044984), Tao Wang (12008), Haiyun Wang (27725), David A. Scott (135462), Peter J. Mohr (1706467), Charles A. Omer (2044990), Hai-Jun Zhang (1529818), Haixia Wang (173360), Michael H. Block (1705567), Fei Gu (23867), Robert J. Kaus (2425081), Terry MacIntyre (1864681), John A. Josey (1833421), Paul D. Lyne (1427734), Audrey M. Davies (2160172), Bin Wang (30851), Yongxin Han (1235268), Yanyi Zhu (2425078)   +21 more
core   +1 more source

Adjuvant Larotrectinib in a Resected Secretory Carcinoma-Like Lung Adenocarcinoma Harboring EML4-NTRK3 Fusion: Case Report

JTO Clinical and Research Reports
Secretory carcinoma of the lung is an exceptionally rare salivary gland-type malignancy, typically associated with NTRK fusions. We report a 71-year-old woman with pulmonary stage IIIA adenocarcinoma having salivary gland differentiation and solid ...
Vladmir Cláudio Cordeiro de Lima, MD, PhD, Breno Jeha Araújo, MD, Felipe D' Almeida Costa, MD, PhD, Beatriz Fuga Rossi Teixeira, MD, André Luiz Cicilini, MD, Carolina de Bustamante Fernandes, PhD, Juliana Folador Morellato, MD, MsC, Rodrigo Dienstmann, MD, MBA, Mariana Tosello Laloni, MD, PhD   +8 more
doaj   +1 more source

Colorectal Cancer: Epidemiology, Risk Factors, Signaling Pathways, Clinical Features, Screening, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
Colorectal cancer is a heterogeneous, adaptive disease shaped by population‐level risk, genomic and epigenetic alterations, tumor ecosystem evolution, and treatment pressure. This review integrates epidemiology, risk factors, signaling networks, clinical presentation, screening, molecular diagnosis, and stage‐ and biomarker‐guided management while ...
Kairui Wan, Ke Tang, Linglong Wang, Qin Tian, Mingwei Zheng, Cheng Qian, Limei Liu   +6 more
wiley   +1 more source