Results 51 to 60 of about 657,649 (153)

Design and synthesis of novel orally selective and type II pan-TRK inhibitors to overcome mutations by property-driven optimization

, 2021
[[abstract]]Rare oncogenic NTRK gene fusions result in uncontrolled TRK signaling leading to various adult and pediatric solid tumors. Based on the architecture of our multi-targeted clinical candidate BPR1K871 (10), we designed and synthesized a series ...
Li, MC;Lin, WH;Wang, PC;Su, YC;Chen, PY;Fan, CM;Chen, CP;Huang, CL;Chiu, CH;Chang, L;Chen, CT;Yeh, TK;Hsieh, HP
core   +1 more source

Recent Advances in Pain Management: Relevant Protein Kinases and Their Inhibitors

Molecules, 2021
The purpose of this review is to underline the protein kinases that have been established, either in fundamental approach or clinical trials, as potential biological targets in pain management.
Francis Giraud, Elisabeth Pereira, Fabrice Anizon, Pascale Moreau   +3 more
doaj   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Rationale and design of ON-TRK: a novel prospective non-interventional study in patients with TRK fusion cancer treated with larotrectinib

, 2022
Background: Tropomyosin receptor kinase (TRK) fusion proteins resulting from neurotrophic tyrosine receptor kinase (NTRK) gene fusions are rare primary oncogenic drivers in a wide array of tumors.
Yang, James C.H., López-Ríos Moreno, Fernando, Trent, Jonathan   +2 more
core   +1 more source

Neurocardiac crosstalk in inherited cardiac arrhythmias and cardiomyopathy

The Journal of Physiology, EarlyView.
Abstract figure legend In inherited cardiac arrhythmias and cardiomyopathy, arrhythmias are typically triggered by autonomic nervous system activity. Genetic mutations linked to these conditions cause pro‐arrhythmic alterations in both cardiomyocytes and neurons, with their pathophysiological crosstalk likely amplifying the manifestation of the disease.
Carol Ann Remme, Molly O'Reilly
wiley   +1 more source

Abstract 16: Landscape and outcome of TRK fusion-positive Cancers

, 2020
TRK inhibitors achieve marked tumor-agnostic efficacy in TRK fusion-positive cancers and consequently are now an established standard of care. Little is known, however, about the demographics, clinical outcomes, response to alternative standard therapies,
Scaltriti, Maurizio, Ritika Kundra, Barry S. Taylor, Schram, Alison M., Sophie Shifman, James P. Solomon, Alberto Bardelli, Goldman, Debra A., Alexander Drilon, Ryma Benayed, David M. Hyman, Alison M. Schram, Drilon, Alexander, Hyman, David M., Solomon, James P., Debra A. Goldman, Shifman, Sophie, Kundra, Ritika, Bardelli, Alberto, Emiliano Cocco, Yixiao Gong, Benayed, Ryma, Maurizio Scaltriti, Iasonos, Alexia, Hechtman, Jaclyn F., Taylor, Barry S., Cocco, Emiliano, Gong, Yixiao, Ezra Y. Rosen, Alexia Iasonos, Rosen, Ezra Y., Jaclyn F. Hechtman   +31 more
core   +1 more source

BPI-28592 as a novel second generation inhibitor for NTRK fusion tumors

npj Precision Oncology
Aberrant activation of tropomyosin receptor kinases (TRKs) is a well-defined oncogenic driver for neurotrophic tropomyosin receptor kinase (NTRK)-fusion cancers, and acquired resistant mutations have emerged with clinical use of the first-generation TRK ...
Jin Sheng, Hong Chen, Bang Fu, Hongming Pan, Jiabing Wang, Weidong Han   +5 more
doaj   +1 more source

Diagnostic challenges and successful organ‐preserving therapy in a case of secretory carcinoma of minor salivary glands

Cancer Reports, 2022
Background Secretory carcinoma is a more recently described subtype of salivary gland carcinoma that may pose diagnostic challenges and frequently harbors NTRK fusions that may successfully be targeted by TRK inhibitors in advanced disease.
Ruben Bill, Daniel G. Deschler, Mikael J. Pittet, Sara I. Pai, Peter M. Sadow, Jong Chul Park   +5 more
doaj   +1 more source

Adolescent Ethanol Exposure Disrupts the Mature Phenotype of Surviving Neuroprogenitors in Female Mice

Hippocampus, Volume 36, Issue 6, November 2026.
ABSTRACT Rodent models of human adolescent binge drinking persistently reduce adult neurogenesis and induce innate immune signaling cascades, suggesting long‐lasting dysfunction in the hippocampal neurogenic niche. Nevertheless, many neuroprogenitors survive, and the impact of adolescent ethanol on the mature phenotype of these surviving neurons is ...
Kaitlyn Campbell, Madison McDowell, Eymani Alston, Hunter Kelley, Michael Kasten, Paul B. Manis, Fulton Crews, Victoria Macht   +7 more
wiley   +1 more source

Prevalence and clinico-genomic characteristics of patients with TRK fusion cancer in China

npj Precision Oncology, 2023
Neurotrophic tyrosine kinase (NTRK) fusions involving NTRK1, NTRK2, and NTRK3 were found in a broad range of solid tumors as driver gene variants. However, the prevalence of NTRK fusions in Chinese solid tumor patients is rarely reported.
Yujun Xu, Xiaoliang Shi, Weifeng Wang, Lin Zhang, Shinghu Cheung, Marion Rudolph, Nicoletta Brega, Xiaowei Dong, Lili Qian, Liwei Wang, Shaohua Yuan, Daniel Shao Weng Tan, Kai Wang   +12 more
doaj   +1 more source