Results 201 to 210 of about 34,671 (227)
Some of the next articles are maybe not open access.
Molecular and Cellular Neuroscience, 2005
NGF binds to two receptors, p75NTR and TrkA. The endosomal trafficking of receptors is of emerging importance for the understanding of their signaling. We compared the endocytic trafficking of the two NGF receptors in PC12 cells. Both p75NTR and TrkA were internalized in response to NGF and colocalized with early endosomes.
Saxena S +7 more
openaire +3 more sources
NGF binds to two receptors, p75NTR and TrkA. The endosomal trafficking of receptors is of emerging importance for the understanding of their signaling. We compared the endocytic trafficking of the two NGF receptors in PC12 cells. Both p75NTR and TrkA were internalized in response to NGF and colocalized with early endosomes.
Saxena S +7 more
openaire +3 more sources
Cancer Research, 2016
Abstract Kinase gene fusions have been implicated as oncogenic drivers promoting cell survival and proliferation. TrkA gene fusions have been reported in a number of cancer types including lung, colorectal, papillary thyroid, sarcoma, cholangiocarcinoma and other tumors. We have identified novel, potent, selective and orally bioavailable
Vijaya G. Tirunagaru +6 more
openaire +1 more source
Abstract Kinase gene fusions have been implicated as oncogenic drivers promoting cell survival and proliferation. TrkA gene fusions have been reported in a number of cancer types including lung, colorectal, papillary thyroid, sarcoma, cholangiocarcinoma and other tumors. We have identified novel, potent, selective and orally bioavailable
Vijaya G. Tirunagaru +6 more
openaire +1 more source
Trends in Cell Biology, 2002
Nerve growth factor (NGF) is the founding member of the neurotrophins, a family of neuronal signaling molecules that are involved in mediating the differentiation and survival of neurons during formation and regeneration of the nervous system. To exert its effects, NGF binds to and activates presynaptic tyrosine kinase (Trk) receptors that convey a ...
openaire +1 more source
Nerve growth factor (NGF) is the founding member of the neurotrophins, a family of neuronal signaling molecules that are involved in mediating the differentiation and survival of neurons during formation and regeneration of the nervous system. To exert its effects, NGF binds to and activates presynaptic tyrosine kinase (Trk) receptors that convey a ...
openaire +1 more source
Proteins: Structure, Function, and Bioinformatics, 2004
AbstractMNAC13, a mouse monoclonal antibody, recognizes with high affinity and specificity the neurotrophin receptor TrkA and displays a neutralizing activity toward the NGF/TrkA interaction. Detailed knowledge of the molecular basis determining the specificity of this antibody is of importance because of its potential use as a modulator of the TrkA ...
Covaceuszach S, Cattaneo A, Lamba D
openaire +5 more sources
AbstractMNAC13, a mouse monoclonal antibody, recognizes with high affinity and specificity the neurotrophin receptor TrkA and displays a neutralizing activity toward the NGF/TrkA interaction. Detailed knowledge of the molecular basis determining the specificity of this antibody is of importance because of its potential use as a modulator of the TrkA ...
Covaceuszach S, Cattaneo A, Lamba D
openaire +5 more sources
TrkA immunoreactive neurones in the rat spinal cord
The Journal of Comparative Neurology, 1997We report the presence in rat spinal cord of a novel neuronal system expressing tyrosine kinase receptor (trkA), the high affinity receptor for nerve growth factor (NGF). TrkA immunoreactive cell bodies were observed in the intermediate grey matter of the spinal cord and were classified into three main groups: central canal cells located dorsolateral ...
G J, Michael +5 more
openaire +2 more sources
Science Signaling, 2001
TrkA receptors for nerve growth factor (NGF) are thought to signal not only at the plasma membrane, but also during transport in vesicles from axons to the cell body where nuclear targets are located. Lou et al . describe association of the TrkA receptor tyrosine kinase with proteins that may help coordinate such ...
openaire +2 more sources
TrkA receptors for nerve growth factor (NGF) are thought to signal not only at the plasma membrane, but also during transport in vesicles from axons to the cell body where nuclear targets are located. Lou et al . describe association of the TrkA receptor tyrosine kinase with proteins that may help coordinate such ...
openaire +2 more sources
2005
Enciklopedijska natuknica govori o povijesti nekadašnjeg viteškog, a danas pučkog konjaničkog natjecanja u istarskom Barbanu.
openaire +1 more source
Enciklopedijska natuknica govori o povijesti nekadašnjeg viteškog, a danas pučkog konjaničkog natjecanja u istarskom Barbanu.
openaire +1 more source
Reactome - a curated knowledgebase of biological pathways, 2007
S Nasi, D Annibali
openaire +1 more source
S Nasi, D Annibali
openaire +1 more source
Alternative TrkA splicing and Cancer
2006The high affinity Nerve Growth Factor receptor TrkA is critical for the development, maturation and maintenance of central and peripheral nervous systems and plays an important role in immune system development and function. TrkA oncogenes exhibit spontaneous ligand-independent activity resulting from activating point mutation, deletion or somatic ...
TACCONELLI A +8 more
openaire +1 more source