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Ultrasensitive proteomics uncovers nociceptor diversity and novel pain targets
Chakrabarti S +6 more
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TrkA signal transduction pathways in neuroblastoma
Medical and Pediatric Oncology, 2001Favorable neuroblastomas frequently express high levels of the TrkA receptor, and these tumors have a propensity to either differentiate or regress, but the mechanisms responsible for these two fates are unclear.To study TrkA signal transduction in neuroblastoma (nb), we stably expressed wild-type TrkA and five TrkA mutants in the human nb cell line SH-
A, Eggert +4 more
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Science Signaling, 2002
Nerve growth factor (NGF), which is a ligand for the Trk receptor tyrosine kinases, has two roles in sympathetic nerve cells: survival and differentiation. Sympathetic neurons also rely on other neurotrophins, such as members of the glial-cell line-derived nuerotrophic factor family ligands (GFLs).
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Nerve growth factor (NGF), which is a ligand for the Trk receptor tyrosine kinases, has two roles in sympathetic nerve cells: survival and differentiation. Sympathetic neurons also rely on other neurotrophins, such as members of the glial-cell line-derived nuerotrophic factor family ligands (GFLs).
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Trends in Cell Biology, 2002
Nerve growth factor (NGF) is the founding member of the neurotrophins, a family of neuronal signaling molecules that are involved in mediating the differentiation and survival of neurons during formation and regeneration of the nervous system. To exert its effects, NGF binds to and activates presynaptic tyrosine kinase (Trk) receptors that convey a ...
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Nerve growth factor (NGF) is the founding member of the neurotrophins, a family of neuronal signaling molecules that are involved in mediating the differentiation and survival of neurons during formation and regeneration of the nervous system. To exert its effects, NGF binds to and activates presynaptic tyrosine kinase (Trk) receptors that convey a ...
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Constitutive TrkA Activity in Receptor-Overexpressing PC12 Clones
Biochemical and Biophysical Research Communications, 2002We have studied ligand-independent signaling by the nerve growth factor receptor TrkA in PC12 clones, under conditions of receptor overexpression. Our results indicate that TrkA-overexpressing PC12 clones display constitutive receptor activation, involving both the mature, 140-kDa form and the immature, intracellular 110-kDa form of the receptor ...
Leoni C, VALTORTA , FLAVIA
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Proteins: Structure, Function, and Bioinformatics, 2004
AbstractMNAC13, a mouse monoclonal antibody, recognizes with high affinity and specificity the neurotrophin receptor TrkA and displays a neutralizing activity toward the NGF/TrkA interaction. Detailed knowledge of the molecular basis determining the specificity of this antibody is of importance because of its potential use as a modulator of the TrkA ...
Covaceuszach S, Cattaneo A, Lamba D
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AbstractMNAC13, a mouse monoclonal antibody, recognizes with high affinity and specificity the neurotrophin receptor TrkA and displays a neutralizing activity toward the NGF/TrkA interaction. Detailed knowledge of the molecular basis determining the specificity of this antibody is of importance because of its potential use as a modulator of the TrkA ...
Covaceuszach S, Cattaneo A, Lamba D
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