Results 261 to 270 of about 34,874 (291)

Pyrazolo[1,5-a]pyrimidine as a Prominent Framework for Tropomyosin Receptor Kinase (Trk) Inhibitors-Synthetic Strategies and SAR Insights. [PDF]

Molecules
Mahajan AT, Shivani, Datusalia AK, Coluccini C, Coghi P, Chaudhary S.   +5 more
europepmc   +1 more source

Zurletrectinib is a next-generation TRK inhibitor with strong intracranial activity against NTRK fusion-positive tumours with on-target resistance to first-generation agents. [PDF]

Br J Cancer
Roa P, Foglizzo V, Harada G, Repetto M, Kulick A, de Stanchina E, de Marchena M, Auwardt S, Sayed Ahmed S, Bremer NV, Yang SR, Feng Y, Zhou C, Kong N, Liang R, Xu H, Zhang B, Bardelli A, Toska E, Ventura A, Drilon A, Cocco E.   +21 more
europepmc   +1 more source

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Dual association of a TRKA polymorphism with schizophrenia

Psychiatric Genetics, 2011
An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with ...
Van Schijndel, Jessica E, Van Zweeden, Martine, Van Loo, Karen M J, Djurovic, Srdjan, Andreassen, Ole A, Hansen, Thomas, Werge, Thomas, Nyegaard, Mette, Sørensen, Karina Meden, Nordentoft, Merete, Mortensen, Preben Bo, Mors, Ole, Børglum, Anders, Del-Favero, Jurgen, Norrback, Karl-Fredrik, Adolfsson, Rolf, Hert, Marc De, Claes, Stephan, Cichon, Sven, Rietschel, Marcella, Nöthen, Markus M, Kallunki, Pekka, Pedersen, Jan T, Martens, Gerard J M   +23 more
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TrkA signal transduction pathways in neuroblastoma

Medical and Pediatric Oncology, 2001
Favorable neuroblastomas frequently express high levels of the TrkA receptor, and these tumors have a propensity to either differentiate or regress, but the mechanisms responsible for these two fates are unclear.To study TrkA signal transduction in neuroblastoma (nb), we stably expressed wild-type TrkA and five TrkA mutants in the human nb cell line SH-
Garrett M. Brodeur, Angelika Eggert, Naohiko Ikegaki, Xing-ge Liu, Thomas T. Chou   +4 more
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TrkAing signals with clathrin

Trends in Cell Biology, 2002
Nerve growth factor (NGF) is the founding member of the neurotrophins, a family of neuronal signaling molecules that are involved in mediating the differentiation and survival of neurons during formation and regeneration of the nervous system. To exert its effects, NGF binds to and activates presynaptic tyrosine kinase (Trk) receptors that convey a ...
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Abstract 2643: Discovery and characterization of a selective TrkA inhibitor for the treatment of TrkA-driven cancers

Cancer Research, 2016
Abstract Kinase gene fusions have been implicated as oncogenic drivers promoting cell survival and proliferation. TrkA gene fusions have been reported in a number of cancer types including lung, colorectal, papillary thyroid, sarcoma, cholangiocarcinoma and other tumors. We have identified novel, potent, selective and orally bioavailable
Srinivas Maddi, Joshi Hemant, Kumaragurubaran Nagaswamy, Sayan Mitra, Jang B. Gupta, Vijaya G. Tirunagaru, Ram Sudheer Adluri   +6 more
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TrkA is necessary for the normal development of the murine thymus

Journal of Neuroimmunology, 2000
Nerve growth factor (NGF) and its signal-transducing receptor TrkA are expressed in the thymus. However, their possible role during thymic organogenesis is unknown. Here we analyze the thymus of trkA-kinase deficient 2-week-old mice. trkA-kinase +/+ and +/- mice had a normal thymus, whereas the thymus of trkA-kinase -/- mice showed lack of delimitation
I. Esteban, José A. Vega, Inmaculada Silos-Santiago, Antonino Germanà, Jonas Hannestad, Jonas Hannestad, Javier Naves, Olivia García-Suárez, Emilia Ciriaco, R. Laurà   +9 more
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Neutralization of NGF‐TrkA receptor interaction by the novel antagonistic anti‐TrkA monoclonal antibody MNAC13: A structural insight

Proteins: Structure, Function, and Bioinformatics, 2004
AbstractMNAC13, a mouse monoclonal antibody, recognizes with high affinity and specificity the neurotrophin receptor TrkA and displays a neutralizing activity toward the NGF/TrkA interaction. Detailed knowledge of the molecular basis determining the specificity of this antibody is of importance because of its potential use as a modulator of the TrkA ...
Covaceuszach S, Cattaneo A, Lamba D
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TrkA immunoreactive neurones in the rat spinal cord

The Journal of Comparative Neurology, 1997
We report the presence in rat spinal cord of a novel neuronal system expressing tyrosine kinase receptor (trkA), the high affinity receptor for nerve growth factor (NGF). TrkA immunoreactive cell bodies were observed in the intermediate grey matter of the spinal cord and were classified into three main groups: central canal cells located dorsolateral ...
Gregory J. Michael, D. O. Clary, John V. Priestley, Marcus Rattray, E. Kaya, Sharon Averill   +5 more
openaire   +2 more sources