Results 101 to 110 of about 10,654 (244)

人神经营养素-3 受体基因的扩增及其重组腺病毒载体的构建

Zhongshan Daxue xuebao. Yixue kexue ban, 2005
【目的】构建人神经营养素-3(neurotrophin-3,NT-3)受体(即酪氨酸蛋白激酶受体C, tyrosine protein kinase C, TrkC)基因重组的腺病毒表达载体。【方法】从人脑组织mRNA 中扩增TrkC 基因全长cDNA, 定向克隆于穿梭质粒pShuttle 中, 获得一个带有CMV 启动子的表达盒。再将表达盒与腺病毒骨架DNA ( Adeno-X viral DNA) 体外连接, 形成重组腺病毒质粒(pAd-TrkC)。用pAd-TrkC 转染人胚肾293 ...
王俊梅, 曾园山, 刘然义, 吴立志, 黄嘉凌, 黄必军, 黄文林   +6 more
doaj  

Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors.

PLoS ONE, 2014
A library of peptidomimetics was assembled combinatorially into dimers on a triazine-based core. The pharmacophore corresponds to β-turns of the neurotrophin polypeptides neurotrophin-3 (NT-3), nerve growth factor (NGF), or brain-derived neurotrophic ...
Fouad Brahimi, Eunhwa Ko, Andrey Malakhov, Kevin Burgess, H Uri Saragovi   +4 more
doaj   +1 more source

Effects of Neurotrophin-3 on Intrinsic Neuronal Properties at a Central Auditory Structure

Neuroscience Insights, 2020
Neurotrophins, a class of growth factor proteins that control neuronal proliferation, morphology, and apoptosis, are found ubiquitously throughout the nervous system. One particular neurotrophin (NT-3) and its cognate tyrosine receptor kinase (TrkC) have
Momoko Takahashi, Jason Tait Sanchez
doaj   +1 more source

Targeted Therapies in the Most Common Advanced Solid Tumors, Drug Resistance, and Counteracting Progressive Micrometastatic Disease: The Next Frontier of Research

MedComm, Volume 6, Issue 10, October 2025.
In TME, undetectable DCCs (panel A) join with a low tumor burden along with low immune suppression, that favor successful immune manipulation through immune suppression inhibiting immune‐therapy. This moves the immune balance toward the immune response and likely makes more stable the dormant state of DCCs in the unstable metastatic niche and/or allows
Andrea Nicolini, Paola Ferrari, Roberto Silvestri, Dario A. Bini   +3 more
wiley   +1 more source

Drosophila Neurotrophins Reveal a Common Mechanism for Nervous System Formation [PDF]

, 2008
Neurotrophic interactions occur in Drosophila, but to date, no neurotrophic factor had been found. Neurotrophins are the main vertebrate secreted signalling molecules that link nervous system structure and function: they regulate neuronal survival ...
Aberle, Alcantara, Alicia Hidalgo, Altar, Arancio, Arenas, Arendt, Armstrong, Bangfu Zhu, Barde, Barres, Beck, Belluardo, Ben Sutcliffe, Benito-Gutierrez, Bergmann, Bergner, Blum, Booth, Bossing, Bothwell, Broihier, Buj-Bello, Burke, Campos, Cash, Chao, Chen, Chevrel, Chun-Jing Gu, Coen, Collette, Collins, Conover, Crowley, Davies, Dearborn, DeLotto, Denes, Dong, Enokido, Ernfors, Ernfors, Fischbach, Freudenthal, Gangloff, Geddes, Halfon, Halfon, Hallbö, Hashimoto, Hemmrich, Henderson, Hidalgo, Hofer, Hu, Huang, Hyman, Inamori, Jaaro, Jacob, Jacobs, Janine C Fenton, Jenny A Pennack, Keishishian, Keishishian, Kenji Mizuguchi, Kirstein, Klein, Landgraf, Landgraf, Landgraf, Landgraf, Landgraf, Learte, Lee, Levi-Montalcini, Ligoxigakis, Liu, Liu, Lu, Ma, Manjon, Manuel G Forero, Martinowich, Mattson, McCabe, Means, Memet, Michael Bate, Minichiello, Mizuguchi, Mizuguchi, Morisato, Moroz, Morris, Noordermeer, Odden, Oppenheim, Oppenheim, Ormond, Parker, Peter McQuilton, Pezet, Putnam, Rogulja-Ortmann, Rose, Roux, Rubin, Sali, Scarabelli, Schmidt, Schwartz, Schweigreiter, Sendtner, Shi, Silos-Santiago, Sink, Sink, Snider, Sofroniew, Sonnenfeld, Sossin, Stadelmann, Staniszewska, Stemerdink, Tauszig, van Kesteren, Venter, Wang, Weber, Weber, White, Wright, Xiong, Zhou, Zweifel   +136 more
core   +4 more sources

Small Molecule Ligands for Active Targeting of TrkC-Expressing Tumor Cells

ACS Medicinal Chemistry Letters, 2012
A small molecule motif was used in "active targeting" to deliver cytotoxic substances into tumor cells that express the TrkC receptor. Underlying this study was the hypothesis that internalization of targeted conjugates into cells would be facile if mediated by receptor binding and receptor-ligand internalization.
Eunhwa, Ko, Anyanee, Kamkaew, Kevin, Burgess   +2 more
openaire   +3 more sources

Developmental Regulation of Full‐length trkC in the Rat Sciatic Nerve [PDF]

European Journal of Neuroscience, 1995
AbstractIn order to gain insight into potential roles of neurotrophins in Schwann cell biology, the expression of neurotrophin receptors of the frk gene family was investigated in rat sciatic nerve development. This analysis revealed differential regulation of truncated and full‐length receptors.
N, Offenhäuser, R, Böhm-Matthaei, P, Tsoulfas, L, Parada, M, Meyer   +4 more
openaire   +2 more sources

Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases

British Journal of Pharmacology, Volume 182, Issue 19, Page 4466-4489, October 2025.
Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota, Theodora Calogeropoulou, Konstantina Chanoumidou, Ioannis Charalampopoulos, Achille Gravanis   +4 more
wiley   +1 more source

Membrane trafficking of synaptic adhesion molecules

The Journal of Physiology, Volume 603, Issue 20, Page 5921-5934, October 15, 2025.
Abstract figure legend Synaptic cellular adhesion molecules are surface transmembrane receptors that have been shown to internalize via endocytosis, and possibly also recycle, in a process that has been linked to the function and the turnover of the synaptic contact site.
Cristian A. Bogaciu, Silvio O. Rizzoli
wiley   +1 more source

Rare Tumors of Oral Cavity: A Case Report and Literature Review on Secretory Carcinoma of Minor Salivary Glands

Clinical and Experimental Dental Research, Volume 11, Issue 4, August 2025.
ABSTRACT Objectives The primary objective of this study is to report and analyze two rare cases of secretory carcinoma (SC) of the minor salivary glands, focusing on their diagnostic and therapeutic work‐up. The study aims to enhance scientific knowledge about SC, which is crucial for developing targeted therapies and ensuring precise diagnosis ...
Emilio Salerno, Silvio Abati, Gianluigi Arrigoni, Daniela Finocchiaro, Giorgio Gastaldi, Alessandra Lissoni, Andrea Galli, Matteo Trimarchi   +7 more
wiley   +1 more source