Results 111 to 120 of about 10,654 (244)

Enhancement of HGF-induced tubulogenesis by endothelial cell-derived GDNF [PDF]

, 2019
学位記番号 ...
Nakasatomi, Masao, ナカサトミ, マサオ, 中里見, 征央   +2 more
core  

p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. [PDF]

, 2013
The p75 neurotrophin receptor (p75(NTR)) is a member of the tumor necrosis factor receptor superfamily with a widespread pattern of expression in tissues such as the brain, liver, lung, and muscle.
Akassoglou, Katerina, Baeza-Raja, Bernat, Eckel-Mahan, Kristin, Ptácek, Louis J, Sassone-Corsi, Paolo, Tsigelny, Igor F, Vagena, Eirini, Zhang, Luoying   +7 more
core   +2 more sources

Role of NTRK Fusion Genes in the Tumor Immune Microenvironment of HPV (+/−) Cervical Cancer

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT Cervical cancer, a prevalent gynecological malignancy, is primarily associated with human papillomavirus (HPV) infection. However, some cases display distinct molecular alterations beyond HPV, significantly impacting the tumor immune microenvironment (TIME) and posing therapeutic challenges.
Qiongying Wang, Chan Zhang, Shijia Liu, Wangshu Li, Wenjuan Wei, Aziz ur Rehman Aziz, Han Lu, Daqing Wang   +7 more
wiley   +1 more source

Preclinical Evaluation of the Oral Toxicity, Genotoxicity, and Safety Pharmacology of LPM4870108, a Novel Potent Tropomyosin Receptor Kinase Inhibitor

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
Preclinical evaluation of the oral toxicity, genotoxicity, and safety pharmacology of LPM4870108. ABSTRACT Tropomyosin receptor kinase (Trk) inhibitors are an essential class of anticancer drugs treating NTRK gene fusions‐positive cancer. However, the potential for the emergence of on‐target resistance suggests newer Trk inhibitors with low drug ...
Xiaochen Zhang, Baiyang Yuan, Chunmei Li, Hongbo Wang, Shujuan Wei, Jingwei Tian, Sijin Duan   +6 more
wiley   +1 more source

Co-transplantation of Human Embryonic Stem Cell-derived Neural Progenitors and Schwann Cells in a Rat Spinal Cord Contusion Injury Model Elicits a Distinct Neurogenesis and Functional Recovery [PDF]

Co-transplantation of neural progenitors (NPs) with Schwann cells (SCs) might be a way to overcome low rate of neuronal differentiation of NPs following transplantation in spinal cord injury (SCI) and the improvement of locomotor recovery. In this study,
Ali Niapour, Ao Q., Baharvand H., Basso D. M., Beattie M. S., Ben-Hur T., Biernaskie J., Blakemore W. F., Bradbury E. J., Brierley C. M., Bruce J. H., Calella A. M., Cao Q. L., Cao Q. L., Castellanos D. A., Cho S. R., Cohen M. A., Cui L., Cummings B. J., Daadi M. M., David S., Deng Y. B., Deshpande D. M., Dhara S. K., Ernsberger U., Fereshteh Karamali, Fouad K., Gage F. H., Golden K. L., Gruner J. A., Haruta M., Hatami M., Hill C. E., Hofstetter C. P., Hong S., Hossein Baharvand, Islam O., Iwanami A., Joannides A. J., Joannides A. J., Kamada T., Kamei N., Karimi-Abdolrezaee S., Kerr D. A., Keyvan-Fouladi N., Kimura H., Koch P., Kumagai G., Li J., Lim M. S., Lindvall O., Livak K. J., Lu P., Lund R. D., Madhavan L., McDonald J. W., Menei P., Meng X. T., Mohammad Hossein Nasr-Esfahani, Mohammad Mardani, Mollamohammadi S., Murray M., Nemati S., Niapour A., Okada S., Olson H. E., Pal R., Papastefanaki F., Parati E. A., Park D. H., Parr A. M., Pearse D. D., Pearse D. D., Pfeifer K., Pincus D. W., Ramer L. M., Roy N. S., Salehi M., Sasaki M., Shin S., Shiva Nemati, Smith R., Takami T., Tetzlaff W., Thuret S., Tobias C. A., Tsuji O., Vargas M. E., Wang G., Webber D. J., Widenfalk J., Willerth S. M., Yan J., Yan J., Zahra Taghipour, Zeng Y. S., Zhang X., Zhang Y. Q.   +97 more
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p75 Neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells [PDF]

, 2007
Although our understanding of adult neurogenesis has increased dramatically over the last decade, confusion still exists regarding both the identity of the stem cell responsible for neuron production and the mechanisms that regulate its activity. Here we
Bartlett, P. F., Coulson, E. J., Merson, T. D., Sotthibundhu, A., Young, K. M.   +4 more
core   +1 more source

Toward molecular phenotyping of temporal lobe epilepsy by spatial omics

Epilepsia, Volume 66, Issue 7, Page 2538-2553, July 2025.
Abstract Objective In temporal lobe epilepsy (TLE), detection of the epileptogenic zone predicts a good surgical outcome. When submitted to 18F‐fluorodeoxyglucose positron emission tomography (PET), some patients display lateralized, focal hypometabolism in the temporal lobe (PET+), whereas others appear normometabolic (PET−).
Isabeau Vermeulen, Ronny Mohren, Micca Neusinger, Tobias A. Dancker, Michiel Vandenbosch, Jan Beckervordersandforth, Benjamin Balluff, Rianna P. Van der Hel, Olaf E. M. G. Schijns, Govert Hoogland, Kim Rijkers, Berta Cillero‐Pastor, ACE epilepsy surgery group, Gwendolyn de Bruyn, Albert Colon, Jim Dings, Marc Hendriks, Danny Hilkman, Christianne Hoeberigs, Jochem van der Pol, Lotte de Jong, Kim Rijkers, Sylvia Klinkenberg, Vivianne van Kranen–Mastenbroek, Jeske Nelissen, Pieter Kubben, Walter M. Palm, Rob P. W. Rouhl, Olaf Schijns, Ilse van Straaten, Simon Tousseyn, Marielle Vlooswijk, Louis Wagner, Dorien Weckhuysen   +33 more
wiley   +1 more source

Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration [PDF]

, 2014
Introduction : The degenerate intervertebral disc (IVD) becomes innervated by sensory nerve fibres, and vascularised by blood vessels. This study aimed to identify neurotrophins, neuropeptides and angiogenic factors within native IVD tissue and to ...
Binch, Abbie L.A., Breakwell, Lee M, Chiverton, Neil, Cole, Ashley A., Cross, Alison K., Le Maitre, Christine L., Michael, Anthony   +6 more
core   +2 more sources

A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles [PDF]

, 2016
Axon-Schwann cell interactions are crucial for the development, function, and repair of the peripheral nervous system, but mechanisms underlying communication between axons and nonmyelinating Schwann cells are unclear.
Abe, Shin-Ichi, Arber, Silvia, Fleming, Michael S., Li, Jian J., Li, Tong, Luo, Wenqin, Ramos, Daniel, Talmage, David A.   +7 more
core   +1 more source

HeyL regulates the number of TrkC neurons in dorsal root ganglia

Developmental Biology, 2009
The basic-helix-loop-helix transcription factor HeyL is expressed at high levels by neural crest progenitor cells (NCPs) that give rise to neurons and glia in dorsal root ganglia (DRG). Since HeyL expression was observed in these NCPs during the period of neurogenesis, we generated HeyL null mutants to help examine the factor's role in ganglion ...
Mukhopadhyay, Abhishek, Jarrett, Jennifer, Chlon, Timothy, Kessler, John A.   +3 more
openaire   +2 more sources