TrkC-Targeted Kinase Inhibitors And PROTACs [PDF]
Molecular Pharmaceutics, 2019 A small molecule motif (IY-IY), which binds the tropomyosin receptor kinase C (TrkC), was used to deliver the promiscuous kinase inhibitor (KI) dasatinib into breast cancer. Conjugates with noncleavable (1) and cleavable (2) linkers were compared in cellular assays and shown to have more impact on the cell viabilities of TrkC+ breast cancer cells over ...
Bosheng Zhao, Kevin Burgess
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Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate [PDF]
Nature Neuroscience, 2004 El pdf del artículo es el manuscrito de autor.-- et al.Tactile information is perceived by a heterogeneous population of specialized neurons. Neurotrophin receptors (the receptor tyrosine kinases, Trks) mark the major classes of these sensory neurons ...
Aziz Moqrich, Ardem Patapoutian
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TrkC plays an essential role in breast tumor growth and metastasis [PDF]
Carcinogenesis, 2010 Tropomyosin-related kinase (Trk) C, a member of the Trk family of neurotrophin receptors, has been implicated in the growth and survival of human cancer tissues. Here, we report that TrkC is frequently overexpressed in human breast cancers and plays an essential role in tumor growth and metastasis.
Wook Jin, Min Soo Kim, Joon Jeong
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Runx3, Brn3a and Isl1 interplay orchestrates the transcriptional program in the early stages of proprioceptive neuron development. [PDF]
PLoS GeneticsBackgroundThe development and diversification of sensory proprioceptive neurons, which reside in the dorsal root ganglia (DRG) and express the tropomyosin receptor kinase C (TrkC), depend on the transcription factor (TF) Runx3.
Kira Orlovsky +6 more
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A temporal (phospho-)proteomic dataset of neurotrophic receptor tyrosine kinase signalling in neuroblastoma [PDF]
Scientific DataNeurotrophic receptor tyrosine kinases (TrkA, TrkB, TrkC), despite their homology, contribute to the clinical heterogeneity of the childhood cancer neuroblastoma.
Stephanie Maher +3 more
doaj +2 more sources
TrkC protects against osteoarthritis progression by maintaining articular cartilage homeostasis. [PDF]
Int J Biol SciChang Y +11 more
europepmc +3 more sources
Altered Primary Somatosensory Neuron Development in a Pten Heterozygous Model for Autism Spectrum Disorder. [PDF]
Autism ResABSTRACT Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social interactions, repetitive behaviors, and hyper‐ or hyposensitivity to sensory stimuli. The cellular mechanisms underlying the emergence of abnormal sensory sensitivity in ASD are not fully understood.
Fernandez A, Sarn N, Eng C, Wright KM.
europepmc +2 more sources
TrkC-CreERT2-mediated recombination supports evidence that TrkC+/TH+ DRG neurons contribute to cardiovascular homeostasis [PDF]
Cell Reports, 2022 In their Matters Arising article, McMullan et al. (2022) offer alternative explanations for the phenotypes we observed upon stimulation and ablation of TrkCCreERT2-positive neurons in mice. Their interpretations are focused on two aspects: first, whether the vasoconstriction we observed upon activation of TrkCCreERT2 neurons is really mediated by TrkC ...
Heppenstall P. A. +2 more
openaire +2 more sources
EMBO ReportsCancer patients undergoing treatment with antineoplastic drugs often experience chemotherapy-induced neuropathic pain (CINP), and the therapeutic options for managing CINP are limited. Here, we show that systemic paclitaxel administration upregulates the
Dilip Sharma +6 more
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