Results 201 to 210 of about 10,654 (244)

Zurletrectinib is a next-generation TRK inhibitor with strong intracranial activity against NTRK fusion-positive tumours with on-target resistance to first-generation agents. [PDF]

open access: yesBr J Cancer
Roa P   +21 more
europepmc   +1 more source

Ouabain increases neuronal differentiation of hippocampal neural precursor cells. [PDF]

open access: yesCurr Res Neurobiol
Orellana AM   +9 more
europepmc   +1 more source

Optimizing Factors in Murine Whole-Organ Cochlea Culture. [PDF]

open access: yesInt J Mol Sci
Tröger A   +6 more
europepmc   +1 more source

TrkC: A New Predictive Marker in Breast Cancer?

Cancer Investigation, 2007
Available data involve neurotrophins and their receptors in carcinomas. Quantitative evaluation of these molecules in these tumors might be useful as prognostic marker and eventual treatments. Our study on 40 mammary tumors tries to correlate expression of these molecules and prognosis. Immunohistochemistry for NGF, BDNF, NT3, TrkA, TrkB, TrkC, and p75
María Jesús, Blasco-Gutiérrez   +4 more
openaire   +2 more sources

The detection of Tel–TrkC chimeric transcripts is more specific than TrkC immunoreactivity for the diagnosis of congenital fibrosarcoma

The Journal of Pathology, 2001
The t(12;15)(p13;q25) translocation, a recurrent chromosomal abnormality of congenital fibrosarcoma, leads to the expression of a Tel-TrkC fusion transcript. To determine whether detection of the chimeric protein may be helpful for the diagnosis of congenital fibrosarcoma, immunohistochemistry was performed with an anti-TrkC antibody on 26 spindle cell
P, Dubus   +10 more
openaire   +2 more sources

Differential effects of TrkC isoforms on sensory axon outgrowth

Journal of Neuroscience Research, 2000
Neurotrophins are powerful regulators of neuronal morphology. Several lines of evidence are consistent with the idea that characteristic axonal and dendritic morphologies throughout the nervous system may be determined by local patterns of neurotrophin and neurotrophin receptor expression.
T, Ichinose, W D, Snider
openaire   +2 more sources

Expression of TrkA, TrkB and TrkC in human neuroblastomas

Journal of Neuro-Oncology, 1997
There is considerable interest in the role of the TRK family of neurotrophin receptors in regulating the survival, growth and differentiation of normal and neoplastic nerve cells. Indeed, there is increasing evidence that TRK genes play an important role in the biology and clinical behavior of neuroblastomas, tumors of the peripheral nervous system ...
G M, Brodeur   +7 more
openaire   +2 more sources

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