Results 211 to 220 of about 10,654 (244)
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trkC may be an inducible transcription factor target gene
NeuroReport, 1995Mechanical injury to hippocampus by needle insertion induces N-methyl-D-aspartate (NMDA) receptor-dependent expression of neurotrophin receptor mRNAs (trkB, trkC) and inducible transcription factors (ITFs, i.e. Fos, c-Jun, Krox-24) in dentate gyrus neurones.
P, Hughes, M, Dragunow
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trkC‐like Immunoreactivity in the Primate Descending Serotoninergic System
European Journal of Neuroscience, 1994AbstractIn the search for substances with a potential role in plastic responses of spinal motoneurons we have studied the distribution of trkC‐like immunoreactivity in the spinal cord of adult monkeys (Macaca fascicularis). The presence of trkC, which is a signal‐transducing receptor for neurotrophin‐3, was detected by the use of indirect ...
U, Arvidsson +6 more
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Heparanase Expression and TrkC/p75NTR Ratios in Human Medulloblastoma
Clinical & Experimental Metastasis, 2006Medulloblastoma (MB), the most devastating and common brain tumor in children, is highly invasive and extremely difficult to treat. Identifying the properties of MB tumors that cause them to invade and metastasize is therefore imperative for the development of novel treatments.
Neeta D, Sinnappah-Kang +3 more
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Molecular Analysis of trkC in the Cat Visual Cortex
Journal of Molecular Neuroscience, 2000trkC belongs to the trk family of neurotrophin receptors. Several isoforms of trkC have been cloned to date; a full-length catalytic form containing a tyrosine kinase (TK) domain, three full-length isoforms with amino-acid insertions (14, 25, and 39 amino acids) in the TK domain, and five noncatalytic truncated forms that completely lack the TK domain.
F, Forooghian +4 more
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Alternative forms of rat TrkC with different functional capabilities
Neuron, 1993We have identified transcripts encoding several different forms of rat TrkC, a member of the Trk family of receptor tyrosine kinases that serves as a receptor for neurotrophin-3. Some forms of TrkC lack the intracytoplasmic kinase domain and thus resemble previously defined truncated variants of TrkB.
Valenzuela, David M. +9 more
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trkA and trkC expression is increased in human diabetic skin
Neuroscience Letters, 1997Nerve growth factor (NGF) is reduced in epidermal keratinocytes in human diabetic skin, and this decrease has been related to dysfunction of cutaneous sensory fibres. In vitro studies show that keratinocytes express both NGF and its high-affinity receptor, trkA, and that NGF may increase keratinocyte proliferation and its own expression via an ...
G, Terenghi +3 more
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Neurotrophin-3 Stimulates Migration of Mesenchymal Stem Cells Overexpressing TrkC
Current Medicinal Chemistry, 2013Transplantation/infusion of mesenchymal stem cells (MSCs) is a promising new approach for treatment of spinal cord injury (SCI). Considering some defined chemokines of MSCs that may have adverse side effects in SCI repair, it is therefore desirable to search for a new chemokine, which should not only be harmless to the host, but also would attract more
Y F, Chen +5 more
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Establishment of a cellular model to study TrkC-dependent neuritogenesis
In Vitro Cellular & Developmental Biology - Animal, 2014The rat PC12 cell line has become a widely used research tool for many aspects of neurobiology. Nerve growth factor (NGF)-responsive PC12 cells were engineered to drive expression of doxycycline (Dox)-induced gene of interest in the Tet-On expression system that resulted in obtaining PC12-Tet-On cells.
Pawel, Krawczyk +4 more
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Gene expression of TrkC (NTRK3) in human soft tissue tumours
The Journal of Pathology, 2002AbstractTrkC is a member of the Trk family of tyrosine kinase receptors and plays an important role in the development and maintenance of neural tissues. Although a variety of non‐neuronal tissues have also been shown to express TrkC, the status of TrkC in soft tissue tumours has been poorly investigated, except for a small fraction of tumours ...
Masanori, Hisaoka +3 more
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Abnormal development of pacinian corpuscles in double trkB;trkC knockout mice
Neuroscience Letters, 2006Pacinian corpuscles depend on either Aalpha or Abeta nerve fibers of the large- and intermediate-sized sensory neurons for the development and maintenance of the structural integrity. These neurons express TrkB and TrkC, two members of the family of signal transducing neurotrophin receptors, and mice lacking TrkB and TrkC lost specific neurons and the ...
DE CARLOS F +7 more
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