Results 221 to 230 of about 10,654 (244)

Emerging roles of the neurotrophin receptor TrkC in synapse organization

Neuroscience Research, 2017
Tropomyosin-receptor-kinase (Trk) receptors have been extensively studied for their roles in kinase-dependent signaling cascades in nervous system development. Synapse organization is coordinated by trans-synaptic interactions of various cell adhesion proteins, a representative example of which is the neurexin-neuroligin complex. Recently, a novel role
Yusuke Naito, Alfred Kihoon Lee, Hideto Takahashi   +2 more
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TrkA and TrkC neurotrophin receptor-like proteins in the lizard gut

Cell and Tissue Research, 2001
The tyrosine kinase proteins (Trk), encoded by the trk family of proto-oncogenes, mediate, in mammals, the action of neurotrophins, a family of growth factors acting on the development and maintenance of the nervous system. Neurotrophins and their specific receptors, TrkA, TrkB and TrkC, seem to be phylogenetically well preserved but, in reptiles, data
LUCINI, CARLA, DE GIROLAMO, PAOLO, LAMANNA C, BOTTE V, VEGA JA, CASTALDO, LUCIANA   +5 more
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Proprioceptive afferents survive in the masseter muscle of trkC knockout mice

Neuroscience, 1999
Peripheral innervation patterns of proprioceptive afferents from dorsal root ganglia and the mesencephalic trigeminal nucleus were assessed in trkC-deficient mice using immunohistochemistry for protein gene product 9.5 and parvalbumin. In trkC knockout mice, spinal proprioceptive afferents were completely absent in the limb skeletal muscles, M.
S, Matsuo, H, Ichikawa, I, Silos-Santiago, J J, Arends, T A, Henderson, K, Kiyomiya, M, Kurebe, M F, Jacquin   +7 more
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Spatiotemporal expression of noncatalytic TrkC NC2 isoform during early and late CNS neurogenesis: a comparative study with TrkC catalytic and p75^NTR receptors

European Journal of Neuroscience, 2000
AbstractThe TrkC subfamily of primary high‐affinity neurotrophin‐3 receptors is composed of catalytic (kinase‐containing; TrkC K) and noncatalytic (TrkC NC) isoforms generated by alternative splicing. We previously reported the presence of the mouse noncatalytic TrkC NC2 isoform in regions of neuronal differentiation [Menn, B., Timsit, S., Calothy, G. &
B, Menn, S, Timsit, A, Represa, S, Mateos, G, Calothy, F, Lamballe   +5 more
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Neurotrophin 3/TrkC‐regulated proteins in the human medulloblastoma cell line DAOY

ELECTROPHORESIS, 2009
AbstractMedulloblastoma (MB) is the most common malignant childhood brain tumor and high neurotrophin (NP) receptor TrkC mRNA expression was identified as a powerful independent predictor of favorable survival outcome. In order to determine downstream effector proteins of TrkC signaling, the MB cell line DAOY was stably transfected with a vector ...
Gruber-Olipitz, M, Ströbel, T, Kang, S U, John, J P P, Grotzer, M A, Slavc, I, Lubec, G   +6 more
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Dimeric β-turn peptidomimetics as ligands for the neurotrophin receptor TrkC

Bioorganic & Medicinal Chemistry Letters, 2001
Twelve dimeric peptidomimetics 1 were prepared via a divergent-convergent strategy. These peptidomimetics incorporated the same amino acids as i +1 and i + 2 residues in key beta-turns of the neurotrophin NT-3. Cytosensor microphysiometry was used to gauge the effects of the dimers 1 on cells that overexpress the NT-3 receptor, TrkC.
A J, Zhang, S, Khare, K, Gokulan, D S, Linthicum, K, Burgess   +4 more
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Expression of TrkC in favorable human neuroblastomas.

Oncogene, 1996
Human neuroblastomas have been found to express the neurotrophin receptors TrkA and TrkB. Expression of TrkA correlates with favorable outcome, while expression of full-length TrkB is associated with unfavorable, more aggressive, N-myc amplified tumors.
D J, Yamashiro, A, Nakagawara, N, Ikegaki, X G, Liu, G M, Brodeur   +4 more
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TrkC‐miR2 regulates TGFβ signaling pathway through targeting of SMAD3 transcript

Journal of Cellular Biochemistry, 2018
AbstractTrkC, neurotrophin receptor, functions inside and outside of the nervous system and has a crucial effect on the regulation of cardiovascular formation. Recently, we introduced TrkC‐miR2 as a novel microRNA located in TrkC gene, which is a regulator of the Wnt signaling pathway. Here, we presented a lot of evidence showing that TrkC‐miR2 also
Sadat Dokanehiifard, Bahram M. Soltani
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TrkC

1998
Tak W. Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders   +4 more
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[ShcD interacts with TrkC through its PTB and SH2 domains].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2012
To study the interaction between ShcD and TrkC and to reveal the molecular mechanism of the downstream signal transduction of TrkC.Yeast two-hybrid assay was used. The intracellular domains of TrkC and TrkC mutants were cloned into pAS2-1, and ShcD and its four domains (CH2, PTB, CH1, and SH2 domains) were cloned into pACT2 vector respectively.
Yuan-gang, You, Wei-qi, Li, Bin, Yin, Xiao-zhong, Peng   +3 more
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