Withdrawal Note: NT-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons. [PDF]
EMBO RepSharma D +6 more
europepmc +2 more sources
TrkC Is Essential for Nephron Function and Trans-Activates Igf1R Signaling [PDF]
Journal of the American Society of Nephrology, 2020 Background Injury to kidney podocytes often results in chronic glomerular disease and consecutive nephron malfunction. For most glomerular diseases, targeted therapies are lacking. Thus, it is important to identify novel signaling pathways contributing to glomerular disease.
Carolin Lepa +14 more
openalex +4 more sources
Genomic characterization of the human trkC gene [PDF]
Oncogene, 1998 The trkC gene encodes the high-affinity receptor for neurotrophin 3 and plays an important role in the regulation of the survival and differentiation of the mammalian nervous system and in heart development. Chromosomal rearrangements of trkC have been recently reported in congenital fibrosarcoma and it has been proposed that abnormal activation of ...
N, Ichaso +3 more
openaire +4 more sources
Retraction Note: Dysregulated JAK2 expression by TrkC promotes metastasis potential, and EMT program of metastatic breast cancer. [PDF]
Sci RepKim MS +5 more
europepmc +3 more sources
An agent for optical imaging of TrkC-expressing, breast cancer [PDF]
MedChemComm, 2017 Tropomyosin receptor kinases receptor C is expressed at high levels on the surface of tumors from metastatic breast cancer, metastatic melanoma, glioblastoma, and neuroblastoma.
Anyanee Kamkaew +3 more
openalex +4 more sources
Cell Death and Disease, 2022 Upregulation of EWSR1-FLI1 expression has been associated with invasiveness, induced cell survival, metastatic dissemination, and acquisition of self-renewal traits in Ewing sarcoma (ES).
Min Soo Kim +3 more
doaj +1 more source
Targeted PDT Agent Eradicates TrkC Expressing Tumors via Photodynamic Therapy (PDT) [PDF]
Molecular Pharmaceutics, 2014 This contribution features a small molecule that binds TrkC (tropomyosin receptor kinase C) receptor that tends to be overexpressed in metastatic breast cancer cells but not in other breast cancer cells. A sensitizer for (1)O2 production conjugated to this structure gives 1-PDT for photodynamic therapy. Isomeric 2-PDT does not bind TrkC and was used as
Chin Siang Kue +5 more
openalex +4 more sources
Cerebral Cortex, 2021 Abstract Neocortical projection neurons are generated by neural progenitor cells (NPCs) within the ventricular and subventricular zone. While early NPCs can give rise to both deep and upper layer neurons, late progenitors are restricted to upper layer neurogenesis.
Srinivas, Parthasarathy +9 more
openaire +2 more sources
Expression of TrkC receptors in the developing brain of the Monodelphis opossum and its effect on the development of cortical cells. [PDF]
PLoS ONE, 2013 In this study, we investigated the distribution, localization and several various functions of TrkC receptors during development of the Monodelphisopossum brain.
Katarzyna Bartkowska +3 more
doaj +1 more source
The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS. [PDF]
PLoS ONE, 2016 Full length TrkC (TrkC-FL) is a receptor tyrosine kinase whose mRNA can be spliced to a truncated TrkC.T1 isoform lacking the kinase domain. Neurotrophin-3 (NT-3) activates TrkC-FL to maintain motor neuron health and function and TrkC.T1 to produce ...
Fouad Brahimi +13 more
doaj +1 more source