Results 31 to 40 of about 10,654 (244)

NEUROPROTECTANT OF 7,8-DIHYDROXYFLAVONE IN ISCHEMIC STROKE THROUGH MODULATION GLUTATHIONE S-TRANSFERASE AND TYROSINE RECEPTOR KINASE C: A BIOINFORMATICS STUDY

Malang Neurology Journal, 2023
Background: Times New Roman 9, single space, contains the brief description of the research. Stroke is the greatest cause of disability and mortality worldwide.
Aldita Husna Violita, Safira Dita Arviana, Rislan Faiz Muhammad, Basyar Adnani, Titin Andri Wihastuti, Husnul Khotimah, Shahdevi Nandar Kurniawan, Yuyun Yueniwati   +7 more
doaj   +1 more source

The Dependence Receptor TrkC Triggers Mitochondria-Dependent Apoptosis upon Cobra-1 Recruitment [PDF]

Molecular Cell, 2013
The neurotrophin receptor TrkC was recently identified as a dependence receptor, and, as such, it triggers apoptosis in the absence of its ligand, NT-3. The molecular mechanism for apoptotic engagement involves the double cleavage of the receptor's intracellular domain, leading to the formation of a proapoptotic "killer" fragment (TrkC KF).
Gabriel Ichim, Anne-Laure Genevois, Marie Ménard, Li-Ying Yu, Juliana M. Coelho‐Aguiar, Fabien Llambi, Loraine Jarrosson-Wuillème, J Lefèbvre, David Tulasne, Élisabeth Dupin, Nicole Le Douarin, Urmas Arumäe, Servane Tauszig-Delamasure, Patrick Mehlen   +13 more
openalex   +3 more sources

TrkC-mediated inhibition of DJ-1 degradation is essential for direct regulation of pathogenesis of hepatocellular carcinoma

Cell Death and Disease, 2022
None of the previous studies has systematically explored how upregulation of TrkC plays a central role in the pathogenesis of hepatocellular carcinoma (HCC) by regulating the underlying mechanisms that promote invasion and metastasis.
Min Soo Kim, Won Sung Lee, Yeonmi Park, Wook Jin   +3 more
doaj   +1 more source

Conversion Surgery After Administration of a TRK Inhibitor for Unresectable Parotid Gland Secretory Carcinoma. [PDF]

Head Neck
ABSTRACT Background The NTRK fusion gene is detected in most salivary gland secretory carcinomas. While tropomyosin receptor kinase (TRK) inhibitors are used for various solid tumors with the fusion gene, there are no reports regarding TRK inhibitor use for unresectable parotid gland carcinomas that subsequently shrink and become resectable.
Nagano A, Matoba T, Kawakita D, Minohara K, Iwaki S, Tsuge H, Tsukamoto K, Kikuchi S, Nakano S, Murase T, Tada Y, Iwasaki S.   +11 more
europepmc   +2 more sources

Conditional deletion of TrkC does not modify limbic epileptogenesis [PDF]

Epilepsy Research, 2012
The neurotrophin receptor, tropomyosin-related kinase B (TrkB), is required for epileptogenesis in the kindling model. The role of a closely related neurotrophin receptor, TrkC, in limbic epileptogenesis is unknown. We examined limbic epileptogenesis in the kindling model in TrkC conditional null mice, using a strategy that previously established a ...
A, Soren Leonard, Ram S, Puranam, Jeffrey, Helgager, Gumei, Liu, James O, McNamara   +4 more
openaire   +2 more sources

Environmental enrichment reverses cerebellar impairments caused by prenatal exposure to a synthetic glucocorticoid

AIMS Neuroscience, 2022
During prenatal life, exposure to synthetic glucocorticoids (SGCs) can alter normal foetal development, resulting in disease later in life. Previously, we have shown alterations in the dendritic cytoarchitecture of Purkinje cells in adolescent rat ...
Martina Valencia , Odra Santander, Eloísa Torres, Natali Zamora, Fernanda Muñoz , Rodrigo Pascual   +5 more
doaj   +1 more source

Muscle Progenitors Derived from Extraocular Muscles Express Higher Levels of Neurotrophins and their Receptors than other Cranial and Limb Muscles [PDF]

, 2020
Extraocular muscles (EOMs) show resistance to muscle dystrophies and sarcopenia. It has been recently demonstrated that they are endowed with different types of myogenic cells, all of which present an outstanding regenerative potential. Neurotrophins are
Benítez Temiño, Beatriz, Carrero Rojas, Génova, Davis López de Carrizosa, María América, Pastor Loro, Ángel Manuel   +3 more
core   +1 more source

Bivalent Diketopiperazine-Based Tropomysin Receptor Kinase C (TrkC) Antagonists [PDF]

Journal of Medicinal Chemistry, 2010
Bivalent molecules containing two beta-turn mimics with side chains that correspond to hot-spots on the neurotrophin NT-3 were prepared. Binding assays showed the mimetics to be selective TrkC ligands, and biological assays showed one mimetic to be an antagonist of the TrkC receptor.
Jing, Liu, Fouad, Brahimi, H Uri, Saragovi, Kevin, Burgess   +3 more
openaire   +2 more sources

Proteins and signalling pathways targeted by dapagliflozin and finerenone: Insights from DAPA-CKD and FIGARO-DKD. [PDF]

Diabetes Obes Metab
Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 750-753, January 2026.
de la Rambelje MA, Voors AA, Greasley PJ, Berger M, Heerspink HJL.   +4 more
europepmc   +2 more sources

TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death [PDF]

, 1997
Newborn mice carrying targeted mutations in genes encoding neurotrophins or their signaling Trk receptors display severe neuronal deficits in the peripheral nervous system but not in the CNS. In this study, we show that trkB (¿/¿) mice have a significant
Alcántara Horrillo, Soledad, Barbacid, Mariano, Frisén, Jonás, Río Fernández, José Antonio del, Silos-Santiago, Inmaculada, Soriano García, Eduardo   +5 more
core   +1 more source