Results 71 to 80 of about 10,654 (244)
Runx1 promotes neuronal differentiation in dorsal root ganglion [PDF]
, 2012 Transcription factor Runx1 controls the cell type specification of peptidergic and nonpeptidergic nociceptive dorsal root ganglion (DRG) neurons by repressing TrkA and calcitonin gene-related peptide (CGRP) expression and activating Ret expression during
Kobayashi Azusa +8 more
core +1 more source
Increased opioid dependence in a mouse model of panic disorder
Frontiers in Behavioral Neuroscience, 2010 Panic disorder is a highly prevalent neuropsychiatric disorder that shows co-occurrence with substance abuse. Here, we demonstrate that TrkC, the high affinity receptor for neurotrophin-3, is a key molecule involved in panic disorder and opiate ...
Xavier Gallego +8 more
doaj +1 more source
Isolation of human pluripotent stem cell-derived sensory neuron subtypes by immunopanning
Frontiers in Cell and Developmental Biology, 2023 Sensory neurons (SNs) detect a wide range of information from the body and the environment that is critical for homeostasis. There are three main subtypes of SNs: nociceptors, mechanoreceptors, and proprioceptors, which express different membrane ...
Kenyi Saito-Diaz +5 more
doaj +1 more source
Advanced Science, Volume 13, Issue 6, 30 January 2026.This study describes derivation of two distinct mechanosensory subpopulations from human pluripotent stem cells using a transcription factor mediated approach. Of significance, functional interrogation of induced mechanosensory subtypes reveal their unique responses to mechanical stimulation in the absence of end‐organs.
Amy J. Hulme +12 more
wiley +1 more source
Synergistic Strategies in Systemic Therapy for Advanced Hepatocellular Carcinoma
Global Challenges, Volume 10, Issue 1, January 2026.This article comprehensively examines the evolving landscape of systemic therapy for advanced hepatocellular carcinoma. It covers the progress in tyrosine kinase inhibitors and immune checkpoint inhibitors, analyzes the efficacy of novel combination strategies, and discusses current challenges like drug resistance and the lack of biomarkers.
Yongxin Yu +5 more
wiley +1 more source
A cell fitness selection model for neuronal survival during development
Nature Communications, 2019 Programmed cell death is an important part of tissue development, and traditionally it is considered that neuronal death is a stochastic process in response to neurotrophic factor deprivation.
Yiqiao Wang +19 more
doaj +1 more source
Journal of Translational Medicine, 2023 Background Maintaining the repair phenotype of denervated Schwann cells in the injured distal nerve is crucial for promoting peripheral nerve regeneration.
Xiong Xu +8 more
doaj +1 more source
Melanoma: Pathogenesis and Targeted Therapy
MedComm, Volume 7, Issue 1, January 2026.The treatment landscape for advanced melanoma has evolved significantly. BRAF–MEK inhibitor combinations are standard for BRAF‐mutant melanoma, whereas targeting NRAS mutations is more challenging, with MEK inhibitors like tunlametinib emerging as an option.
Yang Fu +5 more
wiley +1 more source
The glia response after peripheral nerve injury: A comparison between Schwann cells and olfactory ensheathing cells and their uses for neural regenerative therapies [PDF]
, 2017 The peripheral nervous system (PNS) exhibits a much larger capacity for regeneration than the central nervous system (CNS). One reason for this difference is the difference in glial cell types between the two systems.
Barton, Matthew J. +4 more
core +2 more sources
A chemoattractant role for NT-3 in proprioceptive axon guidance. [PDF]
PLoS Biology, 2004 Neurotrophin-3 (NT-3) is required for proprioceptive neuron survival. Deletion of the proapoptotic gene Bax in NT-3 knockout mice rescues these neurons and allows for examination of their axon growth in the absence of NT-3 signaling.
Bariş Genç +3 more
doaj +1 more source