Results 81 to 90 of about 10,654 (244)

Runx1 selectively regulates cell fate specification and axonal projections of dorsal root ganglion neurons [PDF]

open access: yes, 2007
"平成18年度""2006"--CoverAbstract in JapaneseThesis (Ph. D. in Neuroscience)--University of Tsukuba, (A), no.
吉川 雅朗
core   +1 more source

New, potent, small molecule agonists of tyrosine kinase receptors attenuate dry eye disease

open access: yesFrontiers in Medicine, 2022
Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin3 (NT-3) bind to tyrosine kinase (Trk) receptors, TrkA, TrkB, and TrkC, respectively. This study investigated the efficacy of novel molecule agonists of Trk receptors in
Zhiyuan Yu   +5 more
doaj   +1 more source

Expression and prognostic impact of NTF3 and TrkC in hepatocellular carcinoma

open access: yesScandinavian Journal of Gastroenterology, 2023
Treatment of patients with NTRK fusion-positive cancers using first-generation tropomyosin-related kinase (Trk) inhibitors is associated with high response rates, regardless of tumor histology. However, there have been few studies on neurotrophin-3 (NTF3) and TrkC ligands in hepatocellular carcinoma (HCC).
Hejing, Wang   +4 more
openaire   +2 more sources

Yifei Decoction Regulates the NGF/TRKA/PI3K/AKT Signaling Axis to Inhibit the Epithelial–Mesenchymal Transformation and Proliferation of Pulmonary Epithelial Cells in Bleomycin‐Induced Pulmonary Fibrogenesis

open access: yesCanadian Respiratory Journal, Volume 2026, Issue 1, 2026.
Background It was important to find better therapeutic drugs for idiopathic pulmonary fibrosis (IPF), and in our previous study, Yifei decoction (YFT) alleviated IPF. A deeper understanding of its mechanisms of action could aid in the development of novel treatment strategies.
Lijuan Chen   +9 more
wiley   +1 more source

Early specification of sensory neuron fate revealed by expression and function of neurogenins in the chick embryo [PDF]

open access: yes, 1999
The generation of sensory and autonomic neurons from the neural crest requires the functions of two classes of basic helix-loop-helix (bHLH) transcription factors, the Neurogenins (NGNs) and MASH-1, respectively (Fode, C., Gradwohl, G., Morin, X ...
Anderson, David J.   +2 more
core  

Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation

open access: yesNeural Development, 2010
The transcription factor Brn3a, product of the pou4f1 gene, is expressed in most sensory neurons throughout embryogenesis. Prior work has demonstrated a role for Brn3a in the repression of early neurogenic genes; here we describe a second major role for ...
Raisa Eng S   +3 more
doaj   +1 more source

Regenerating the Senses: Stem Cell‐Derived Sensory Neurons and Functional Genomics in Neurological Disorders

open access: yesSensory Neuroscience, Volume 1, Issue 3, December 2025.
ABSTRACT Sensory neuron disorders, such as peripheral neuropathies and trigeminal neuralgia, cause chronic pain and sensory dysfunction; however, regenerative treatments are limited. Human pluripotent stem cells (hPSCs) provide a powerful platform to model these diseases by generating functional sensory neuron subtypes, including nociceptors and ...
Pushpanathan Muthuirulan   +3 more
wiley   +1 more source

Propioceptores articulares y musculares [PDF]

open access: yes, 1999
La función de los mecanorreceptores de las articulaciones y músculos se considera asociada a la propiocepción. Sin embargo, existen evidencias de que la propiocepción no sólo depende del morfotipo de mecanorreceptor presente en dichos tejidos sino ...
Vega, José A.
core   +2 more sources

Arsenic trioxide induces cell cycle arrest and affects Trk receptor expression in human neuroblastoma SK-N-SH cells

open access: yesBiological Research, 2018
Background Arsenic trioxide (As2O3), a drug that has been used in China for approximately two thousand years, induces cell death in a variety of cancer cell types, including neuroblastoma (NB).
Xilin Xiong   +6 more
doaj   +1 more source

Characteristics of sensory neuronal groups in CGRP-cre-ER reporter mice: Comparison to Nav1.8-cre, TRPV1-cre and TRPV1-GFP mouse lines. [PDF]

open access: yesPLoS ONE, 2018
Peptidergic sensory neurons play a critical role in nociceptive pathways. To precisely define the function and plasticity of sensory neurons in detail, new tools such as transgenic mouse models are needed.
Mayur J Patil   +2 more
doaj   +1 more source

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