The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS. [PDF]
PLoS ONE, 2016 Full length TrkC (TrkC-FL) is a receptor tyrosine kinase whose mRNA can be spliced to a truncated TrkC.T1 isoform lacking the kinase domain. Neurotrophin-3 (NT-3) activates TrkC-FL to maintain motor neuron health and function and TrkC.T1 to produce ...
Fouad Brahimi +13 more
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Srsf1 and Elavl1 act antagonistically on neuronal fate choice in the developing neocortex by controlling TrkC receptor isoform expression. [PDF]
Nucleic Acids Res, 2023 The seat of higher-order cognitive abilities in mammals, the neocortex, is a complex structure, organized in several layers. The different subtypes of principal neurons are distributed in precise ratios and at specific positions in these layers and are ...
Weber AI +12 more
europepmc +4 more sources
The TrkC-PTPσ complex governs synapse maturation and anxiogenic avoidance via synaptic protein phosphorylation [PDF]
The EMBO JournalThe precise organization of pre- and postsynaptic terminals is crucial for normal synaptic function in the brain. In addition to its canonical role as a neurotrophin-3 receptor tyrosine kinase, postsynaptic TrkC promotes excitatory synapse organization ...
Husam Khaled +14 more
doaj +3 more sources
Proneurotrophin-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons [PDF]
EMBO ReportsCancer patients undergoing treatment with antineoplastic drugs often experience chemotherapy-induced neuropathic pain (CINP), and therapeutic options for managing CINP are limited.
Dilip Sharma +7 more
doaj +3 more sources
A Small-Molecule TrkB/TrkC Ligand Promotes Neurogenesis and Behavioral Recovery Following Traumatic Brain Injury [PDF]
Neurotrauma ReportsTropomyosin receptor-kinase B (TrkB) and TrkC neurotrophin receptors promote neuronal growth and differentiation during the development and maintenance of structural integrity and plasticity in adult animals.
Jian Shi +5 more
doaj +3 more sources
Neurotrophin-3 provides neuroprotection via TrkC receptor dependent pErk5 activation in a rat surgical brain injury model. [PDF]
Exp Neurol, 2018 Akyol O +8 more
europepmc +4 more sources
A temporal (phospho-)proteomic dataset of neurotrophic receptor tyrosine kinase signalling in neuroblastoma [PDF]
Scientific DataNeurotrophic receptor tyrosine kinases (TrkA, TrkB, TrkC), despite their homology, contribute to the clinical heterogeneity of the childhood cancer neuroblastoma.
Stephanie Maher +3 more
doaj +3 more sources
Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor. [PDF]
PLoS Genet, 2014 Neurotrophins and their receptors control a number of cellular processes, such as survival, gene expression and axonal growth, by activating multiple signalling pathways in peripheral neurons.
Gorokhova S +8 more
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Frontiers in Neuroanatomy, 2020 In therian mammals, the cerebellum is one of the late developing structures in the brain. Specifically, the proliferation of cerebellar granule cells occurs after birth, and even in humans, the generation of these cells continues during the first year of
Beata Tepper +6 more
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Expression of TrkC receptors in the developing brain of the Monodelphis opossum and its effect on the development of cortical cells. [PDF]
PLoS ONE, 2013 In this study, we investigated the distribution, localization and several various functions of TrkC receptors during development of the Monodelphisopossum brain.
Katarzyna Bartkowska +3 more
doaj +3 more sources