Sensory Neuroscience, Volume 1, Issue 3, December 2025.ABSTRACT Sensory neuron disorders, such as peripheral neuropathies and trigeminal neuralgia, cause chronic pain and sensory dysfunction; however, regenerative treatments are limited. Human pluripotent stem cells (hPSCs) provide a powerful platform to model these diseases by generating functional sensory neuron subtypes, including nociceptors and ...
Pushpanathan Muthuirulan +3 more
wiley +1 more source
Neural Development, 2010 The transcription factor Brn3a, product of the pou4f1 gene, is expressed in most sensory neurons throughout embryogenesis. Prior work has demonstrated a role for Brn3a in the repression of early neurogenic genes; here we describe a second major role for ...
Raisa Eng S +3 more
doaj +1 more source
Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis [PDF]
, 2014 Receptor protein tyrosine phosphatase sigma (RPTPσ) regulates neuronal extension and acts as a presynaptic nexus for multiple protein and proteoglycan interactions during synaptogenesis.
Aricescu, AR +9 more
core +2 more sources
The Concise Guide to PHARMACOLOGY 2025/26: Catalytic receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S259-S306, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
Analysis of the Expression of Neurotrophins and Their Receptors in Adult Zebrafish Kidney
Veterinary Sciences, 2022 Neurotrophins and their receptors are involved in the development and maintenance of neuronal populations. Different reports have shown that all neurotrophin/receptor pathways can also play a role in several non-neuronal tissues in vertebrates, including
Pietro Cacialli, Carla Lucini
doaj +1 more source
Combination of Electroacupuncture and Grafted Mesenchymal Stem Cells Overexpressing TrkC Improves Remyelination and Function in Demyelinated Spinal Cord of Rats [PDF]
, 2015 10.1038/srep09133Scientific ...
Ding, Ying +8 more
core +2 more sources
Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration [PDF]
, 2014 Introduction : The degenerate intervertebral disc (IVD) becomes innervated by sensory nerve fibres, and vascularised by blood vessels. This study aimed to identify neurotrophins, neuropeptides and angiogenic factors within native IVD tissue and to ...
Binch, Abbie L.A. +6 more
core +2 more sources
Roles of TrkC Signaling in the Regulation of Tumorigenicity and Metastasis of Cancer
Cancers, 2020 Tropomyosin receptor kinase (Trk) C contributes to the clinicopathology of a variety of human cancers, and new chimeric oncoproteins containing the tyrosine kinase domain of TrkC occur after fusion to the partner genes.
W. Jin
semanticscholar +1 more source
Early specification of sensory neuron fate revealed by expression and function of neurogenins in the chick embryo [PDF]
, 1999 The generation of sensory and autonomic neurons from the neural crest requires the functions of two classes of basic helix-loop-helix (bHLH) transcription factors, the Neurogenins (NGNs) and MASH-1, respectively (Fode, C., Gradwohl, G., Morin, X ...
Anderson, David J. +2 more
core
Microarray Analysis Reveals Increased Transcriptional Repression and Reduced Metabolic Activity but Not Major Changes in the Core Apoptotic Machinery during Maturation of Sympathetic Neurons [PDF]
, 2016 Postnatal maturation of the neurons whose main phenotype and basic synaptic contacts are already established includes neuronal growth, refinement of synaptic contacts, final steps of differentiation, programmed cell death period (PCD) etc.
Jaan ePalgi +4 more
core +1 more source