Results 131 to 140 of about 2,313,793 (272)

Novel clinical trial designs emerging from the molecular reclassification of cancer

CA: A Cancer Journal for Clinicians, Volume 75, Issue 3, Page 243-267, May/June 2025.
Abstract Next‐generation sequencing has revealed the disruptive reality that advanced/metastatic cancers have complex and individually distinct genomic landscapes, necessitating a rethinking of treatment strategies and clinical trial designs. Indeed, the molecular reclassification of cancer suggests that it is the molecular underpinnings of the disease,
Mina Nikanjam, Shumei Kato, Teresa Allen, Jason K. Sicklick, Razelle Kurzrock   +4 more
wiley   +1 more source

Investigating the changes of hippocampal m-RNA gene expression of neurotrophin-3 and its receptor (Tropomyosin Receptor Kinase C) in the recovery of movements of rats with spinal cord injury during two types of endurance exercises [PDF]

Medical Laboratory Journal
Background: This study aimed to investigate the effect of four weeks of selected endurance training on neurotrophin-3 (NT-3) and tropomyosin receptor kinase C (TrkC) gene expression in hippocampal areas of rats with spinal cord injury (SCI).
Sina Jalili Rasti, Mohammad Amin Younessi Heravi, Ali Yaghubi, Sadegh Cheragh Birjandi   +3 more
doaj  

Isolation and characterization of neural crest progenitors from adult dorsal root ganglia [PDF]

, 2007
After peripheral nerve injury, the number of sensory neurons in the adult dorsal root ganglia (DRG) is initially reduced but recovers to a normal level several months later. The mechanisms underlying the neuronal recovery after injury are not clear. Here,
Abrous, Ballas, Bedford, Belmadani, Berg, Bixby, Bondurand, Campos, Cecchini, Cheung, Chie, Ciaroni, Corti, Cosgaya, Crane, Devor, Elson, Eng, Evonne Hwee Min Say, Farel, Farel, Farinas, Fernandes, Greenwood, Grothe, Groves, Groves, Groves, Hagedorn, Hong-Yun Li, Hu, Iwashita, Jessen, Kleber, Kruger, Kruger, Kuo, La Forte, Le Douarin, Lee, Lendahl, Lindsay, Lo, Lopez, Ma, Marmigere, Maro, Ming, Mohammed, Molofsky, Mori, Morrison, Murphy, Namaka, Okano, Popken, Pover, Rask-Andersen, Real, Sauka-Spengler, Sommer, Stemple, Steventon, Stewart, Svenningsen, Tomita, Tucker, Valero, Wiggins, Wong, Xian, Xin-Fu Zhou, Yamashita, Yoon, Young, Yun, Zhou, Zhou   +77 more
core   +1 more source

Development of primary sensory neurons in the trigeminal nervous system; dependency on neurotrophins and other substances

Japanese Dental Science Review, 2012
This review presents information about the development of primary sensory neurons in the trigeminal nervous system. The deficiency of high affinity receptors for nerve growth factor (trkA) and neurotrophin-3 (trk-C) causesa reduction of primary ...
Hiroyuki Ichikawa, Saburo Matsuo, Tomosada Sugimoto   +2 more
doaj   +1 more source

Co-transplantation of Human Embryonic Stem Cell-derived Neural Progenitors and Schwann Cells in a Rat Spinal Cord Contusion Injury Model Elicits a Distinct Neurogenesis and Functional Recovery [PDF]

Co-transplantation of neural progenitors (NPs) with Schwann cells (SCs) might be a way to overcome low rate of neuronal differentiation of NPs following transplantation in spinal cord injury (SCI) and the improvement of locomotor recovery. In this study,
Ali Niapour, Ao Q., Baharvand H., Basso D. M., Beattie M. S., Ben-Hur T., Biernaskie J., Blakemore W. F., Bradbury E. J., Brierley C. M., Bruce J. H., Calella A. M., Cao Q. L., Cao Q. L., Castellanos D. A., Cho S. R., Cohen M. A., Cui L., Cummings B. J., Daadi M. M., David S., Deng Y. B., Deshpande D. M., Dhara S. K., Ernsberger U., Fereshteh Karamali, Fouad K., Gage F. H., Golden K. L., Gruner J. A., Haruta M., Hatami M., Hill C. E., Hofstetter C. P., Hong S., Hossein Baharvand, Islam O., Iwanami A., Joannides A. J., Joannides A. J., Kamada T., Kamei N., Karimi-Abdolrezaee S., Kerr D. A., Keyvan-Fouladi N., Kimura H., Koch P., Kumagai G., Li J., Lim M. S., Lindvall O., Livak K. J., Lu P., Lund R. D., Madhavan L., McDonald J. W., Menei P., Meng X. T., Mohammad Hossein Nasr-Esfahani, Mohammad Mardani, Mollamohammadi S., Murray M., Nemati S., Niapour A., Okada S., Olson H. E., Pal R., Papastefanaki F., Parati E. A., Park D. H., Parr A. M., Pearse D. D., Pearse D. D., Pfeifer K., Pincus D. W., Ramer L. M., Roy N. S., Salehi M., Sasaki M., Shin S., Shiva Nemati, Smith R., Takami T., Tetzlaff W., Thuret S., Tobias C. A., Tsuji O., Vargas M. E., Wang G., Webber D. J., Widenfalk J., Willerth S. M., Yan J., Yan J., Zahra Taghipour, Zeng Y. S., Zhang X., Zhang Y. Q.   +97 more
core   +2 more sources

Neurotrophins are expressed in giant cell arteritis lesions and may contribute to vascular remodeling [PDF]

, 2014
International audienceIntroduction: Giant cell arteritis (GCA) is characterized by intimal hyperplasia leading to ischaemic manifestations that involve large vessels.
Alexis Régent, Anne-Laure Fauchais, Antoine Brézin, Claire Le-Jeunne, Elisabeth Vidal, Elsa Molina, François Labrousse, Jean-Louis Bourges, Kim Heang Ly, Luc Mouthon, Marie-Odile Jauberteau, Philippe Bertin, Philippe Sindou, Pierre-Yves Robert, Sofiane Saada, Véronique Witko-Sarsat   +15 more
core   +2 more sources

REST/NRSF Knockdown Alters Survival, Lineage Differentiation and Signaling in Human Embryonic Stem Cells. [PDF]

, 2015
REST (RE1 silencing transcription factor), also known as NRSF (neuron-restrictive silencer factor), is a well-known transcriptional repressor of neural genes in non-neural tissues and stem cells.
Jan, Majib, John, Alan, Koleilat, Tasneem, Pyle, April D, Thakore-Shah, Kaushali   +4 more
core   +3 more sources

A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles [PDF]

, 2016
Axon-Schwann cell interactions are crucial for the development, function, and repair of the peripheral nervous system, but mechanisms underlying communication between axons and nonmyelinating Schwann cells are unclear.
Abe, Shin-Ichi, Arber, Silvia, Fleming, Michael S., Li, Jian J., Li, Tong, Luo, Wenqin, Ramos, Daniel, Talmage, David A.   +7 more
core   +1 more source

TrkC-Targeted Kinase Inhibitors And PROTACs.

Molecular Pharmaceutics, 2019
A small molecule motif (IY-IY), which binds the tropomyosin receptor kinase C (TrkC), was used to deliver the promiscuous kinase inhibitor (KI) dasatinib into breast cancer.
Bosheng Zhao, K. Burgess
semanticscholar   +1 more source

Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival.

PLoS ONE, 2011
BackgroundNeurotrophin receptors were initially identified in neural cells. They were recently detected in some cancers in association with invasiveness, but the function of these tyrosine kinase receptors was not previously investigated in colorectal ...
Hussein Akil, Aurélie Perraud, Carole Mélin, Marie-Odile Jauberteau, Muriel Mathonnet   +4 more
doaj   +1 more source