Trackins (Trk-Targeting Drugs): A Novel Therapy for Different Diseases
PharmaceuticalsMany routes may lead to the transition from a healthy to a diseased phenotype. However, there are not so many routes to travel in the opposite direction; that is, therapy for different diseases.
George N. Chaldakov +8 more
doaj +1 more source
, 2005 International audienceIn the developing rat hippocampus, GABAergic synapses undergo a Ca2+-dependent long-term potentiation (LTP(GABA-A)); this form of synaptic plasticity is induced in CA3 pyramidal neurons by delivering repetitive depolarizing pulses ...
Ben-Ari, Yehezkel +2 more
core +5 more sources
Development of Bone Morphogenetic Protein Receptors in the Nervous System and Possible Roles in Regulating trkC Expression [PDF]
, 1998 Damin Zhang +3 more
openalex +1 more source
TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo.
, 1996 Anne M. Fagan +5 more
openalex +2 more sources
Auto‐antibodies to Receptor Tyrosine Kinases TrkA, TrkB and TrkC in Patients with Chronic Chagas’ Disease [PDF]
, 2008 Bo Lü +3 more
openalex +1 more source
BPI-28592 as a novel second generation inhibitor for NTRK fusion tumors
npj Precision OncologyAberrant activation of tropomyosin receptor kinases (TRKs) is a well-defined oncogenic driver for neurotrophic tropomyosin receptor kinase (NTRK)-fusion cancers, and acquired resistant mutations have emerged with clinical use of the first-generation TRK ...
Jin Sheng +5 more
doaj +1 more source
c-Src Is Required for Tropomyosin Receptor Kinase C (TrkC)-induced Activation of the Phosphatidylinositol 3-Kinase (PI3K)-AKT Pathway [PDF]
, 2007 Wook Jin +5 more
openalex +1 more source
Inhibition of the NT-3 Receptor TrkC, Early in Chick Embryogenesis, Results in Severe Reductions in Multiple Neuronal Subpopulations in the Dorsal Root Ganglia [PDF]
, 1996 Frances Lefcort +3 more
openalex +1 more source
Entrectinib and other ALK/TRK inhibitors for the treatment of neuroblastoma
Drug Design, Development and Therapy, 2018 Holly L Pacenta, Margaret E Macy Department of Pediatrics, University of Colorado Anschutz Medical Campus and Children’s Hospital Colorado, Aurora, CO, USA Abstract: RTK plays important roles in many cellular signaling processes involved in ...
Pacenta HL, Macy ME
doaj