Evidence for a Role of Truncated trkC Receptor Isoforms in Mouse Development [PDF]
The Journal of Neuroscience, 1999 The trkC locus encodes several receptors for neurotrophin-3, including the well studied full-length tyrosine kinase isoform, in addition to receptor isoforms lacking the kinase active domain.
Mary Ellen Palko +2 more
semanticscholar +5 more sources
A kinase-deficient TrkC receptor isoform activates Arf6–Rac1 signaling through the scaffold protein tamalin [PDF]
The Journal of Cell Biology, 2006 Neurotrophins play an essential role in mammalian development. Most of their functions have been attributed to activation of the kinase-active Trk receptors and the p75 neurotrophin receptor.
Pedro F. Esteban +9 more
semanticscholar +4 more sources
Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors.
PLoS ONE, 2014 A library of peptidomimetics was assembled combinatorially into dimers on a triazine-based core. The pharmacophore corresponds to β-turns of the neurotrophin polypeptides neurotrophin-3 (NT-3), nerve growth factor (NGF), or brain-derived neurotrophic ...
Fouad Brahimi +4 more
doaj +5 more sources
The Dependence Receptor TrkC Triggers Mitochondria-Dependent Apoptosis upon Cobra-1 Recruitment [PDF]
Molecular Cell, 2013 The neurotrophin receptor TrkC was recently identified as a dependence receptor, and, as such, it triggers apoptosis in the absence of its ligand, NT-3. The molecular mechanism for apoptotic engagement involves the double cleavage of the receptor's intracellular domain, leading to the formation of a proapoptotic "killer" fragment (TrkC KF).
Gabriel Ichim +13 more
semanticscholar +4 more sources
Antibody-dependent cellular phagocytosis of tropomyosin receptor kinase C (TrkC) expressing cancer cells for targeted immunotherapy [PDF]
Cancer Immunology, Immunotherapy, 2022 Conventional cancer therapies such as chemotherapy are non-selective and induce immune system anergy, which lead to serious side effects and tumor relapse. It is a challenge to prime the body's immune system in the cancer-bearing subject to produce cancer antigen-targeting antibodies, as most tumor-associated antigens are expressed abundantly in cancer
Phei San Lai +6 more
semanticscholar +5 more sources
Selective inhibitors of the TrkC.T1 receptor reduce retinal inflammation and delay neuronal death in a model of retinitis pigmentosa. [PDF]
PNAS NexusThe heterogeneity of receptor isoforms can cause an apparent paradox where each isoform can promote different or even opposite biological pathways. One example is the neurotrophin receptor TrkC.
Brahimi F +9 more
europepmc +2 more sources
Selective activation and down‐regulation of Trk receptors by neurotrophins in human neurons co‐expressing
Journal of Neurochemistry, 2022 In the central nervous system, most neurons co‐express TrkB and TrkC, the tyrosine kinase receptors for brain‐derived neurotrophic factor (BDNF) and neurotrophin‐3 (NT3). As NT3 can also activate TrkB, it has been difficult to understand how NT3 and TrkC
Sarah Ateaque +7 more
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Identification and structural analysis of a selective tropomyosin receptor kinase C (TRKC) inhibitor
European Journal of Medicinal Chemistry, 2022 Tropomyosin receptor kinases (TRKs) are a family of TRKA, TRKB and TRKC isoforms. It has been widely reported that TRKs are implicated in a variety of tumors with several Pan-TRK inhibitors currently being used or evaluated in clinical treatment. However, off-target adverse events frequently occur in the clinical use of Pan-TRK inhibitors, which result
Zhijie Wang +18 more
semanticscholar +4 more sources
Frontiers in Endocrinology, 2021 Neurotrophin-3 (NT3), through activation of its tropomyosin-related kinase receptor C (TrkC), modulates neuronal survival and neural stem cell differentiation.
María Bové +26 more
doaj +2 more sources
Neurotrophin-3 Increases Intracellular Calcium in a Rat Insulin-secreting Cell Line through Its Action on a Functional TrkC Receptor [PDF]
Journal of Biological Chemistry, 1996 Pancreatic beta cells and neuronal cells show a large number of similarities. For example, functional receptors for nerve growth factor are present in beta cells.
A. Tazi +5 more
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