Results 221 to 230 of about 2,313,793 (272)

TrkA and TrkC neurotrophin receptor-like proteins in the lizard gut

Cell and Tissue Research, 2001
The tyrosine kinase proteins (Trk), encoded by the trk family of proto-oncogenes, mediate, in mammals, the action of neurotrophins, a family of growth factors acting on the development and maintenance of the nervous system. Neurotrophins and their specific receptors, TrkA, TrkB and TrkC, seem to be phylogenetically well preserved but, in reptiles, data
LUCINI, CARLA, DE GIROLAMO, PAOLO, LAMANNA C, BOTTE V, VEGA JA, CASTALDO, LUCIANA   +5 more
openaire   +5 more sources

Dimeric β-turn peptidomimetics as ligands for the neurotrophin receptor TrkC

Bioorganic & Medicinal Chemistry Letters, 2001
Twelve dimeric peptidomimetics 1 were prepared via a divergent-convergent strategy. These peptidomimetics incorporated the same amino acids as i +1 and i + 2 residues in key beta-turns of the neurotrophin NT-3. Cytosensor microphysiometry was used to gauge the effects of the dimers 1 on cells that overexpress the NT-3 receptor, TrkC.
A J, Zhang, S, Khare, K, Gokulan, D S, Linthicum, K, Burgess   +4 more
openaire   +2 more sources

Valproic Acid Upregulates The Expression of The Neurotrophin Receptor TrkC in Human Neuroblastoma Cells

The FASEB Journal, 2020
Preclinical and clinical studies have shown that the Trk receptors of neurotrophic factors play an important role in regulating the biological properties and the clinical evolution of neuroblastoma, the most frequent extracranial solid tumor in childhood.
S. Dedoni, L. Marras, M. Olianas, A. Ingianni, P. Onali   +4 more
semanticscholar   +1 more source

Neurotrophin 3 and its Receptor TrkC Immunoreactivity in Glucagon Cells of Buffalo Pancreas

Anatomia, Histologia, Embryologia, 2003
SummaryNeurotrophin 3 (NT3), a member of the neurotrophin family, and its specific receptor tyrosine kinase C (TrkC) are involved in the differentiation, survival, and maintenance of many neuronal populations. Recently, NT3 and TrkC were also retained involved in the biology of non‐neuronal tissues.
LUCINI, CARLA, COSTAGLIOLA C, BORZACCHIELLO, GIUSEPPE, CASTALDO, LUCIANA   +3 more
openaire   +3 more sources

Voluntary exercise increases neurotrophin-3 and its receptor TrkC in the spinal cord

Brain Research, 2003
We have evaluated changes in the expression of neurotrophin-3 (NT-3) and its tyrosine kinase C (TrkC) receptor in the neuromuscular system as a result of voluntary physical activity. We assessed changes in the mRNAs and proteins for NT-3 and TrkC in the lumbar spinal cord and associated soleus muscle following 3 and 7 days of voluntary wheel running ...
Zhe, Ying, Roland R, Roy, V Reggie, Edgerton, Fernando, Gómez-Pinilla   +3 more
openaire   +2 more sources

TrkB but not trkC receptors are necessary for postnatal maintenance of hippocampal spines

Neurobiology of Aging, 2008
Dendritic spines are major sites of excitatory synaptic transmission and changes in their densities have been linked to alterations in learning and memory. The neurotrophins brain-derived neurotrophic factor and neurotrophin-3 and their receptors, trkB and trkC, are thought to be involved in learning, memory and long-term potentiation (LTP).
O, von Bohlen und Halbach, L, Minichiello, K, Unsicker   +2 more
openaire   +2 more sources

TrkC-T1, the Non-Catalytic Isoform of TrkC, Governs Neocortical Progenitor Fate Specification by Inhibition of MAP Kinase Signaling.

Cerebral Cortex, 2021
Neocortical projection neurons are generated by neural progenitor cells (NPCs) within the ventricular and subventricular zone. While early NPCs can give rise to both deep and upper layer neurons, late progenitors are restricted to upper layer ...
S. Parthasarathy, S. Srivatsa, A. I. Weber, Nikolaus Gräber, O. Britanova, E. Borisova, P. Bessa, M. Ambrozkiewicz, M. Rosário, V. Tarabykin   +9 more
semanticscholar   +1 more source

Spatiotemporal expression of noncatalytic TrkC NC2 isoform during early and late CNS neurogenesis: a comparative study with TrkC catalytic and p75^NTR receptors

European Journal of Neuroscience, 2000
AbstractThe TrkC subfamily of primary high‐affinity neurotrophin‐3 receptors is composed of catalytic (kinase‐containing; TrkC K) and noncatalytic (TrkC NC) isoforms generated by alternative splicing. We previously reported the presence of the mouse noncatalytic TrkC NC2 isoform in regions of neuronal differentiation [Menn, B., Timsit, S., Calothy, G. &
B, Menn, S, Timsit, A, Represa, S, Mateos, G, Calothy, F, Lamballe   +5 more
openaire   +2 more sources

Mice lacking NT-3, and its receptor TrkC, exhibit profound deficiencies in CNS glial cells

Glia, 1999
Neurotrophin-3 (NT-3) and its receptor TrkC are known to be important for neuronal survival. More recently, NT-3 has been implicated as playing a role in oligodendrocyte (OL) proliferation and survival in vitro. Examination of NT-3 and TrkC knockout mice revealed a reduction in NT-3-dependent neurons. To date, no study has examined alterations in glial
M A, Kahn, S, Kumar, D, Liebl, R, Chang, L F, Parada, J, De Vellis   +5 more
openaire   +2 more sources

Axon‐derived PACSIN1 binds to the Schwann cell survival receptor, LRP1, and transactivates TrkC to promote gliatrophic activities

Glia
Schwann cells (SCs) undergo phenotypic transformation and then orchestrate nerve repair following PNS injury. The ligands and receptors that activate and sustain SC transformation remain incompletely understood.
S. Martellucci, Andreas Flütsch, Mark Carter, Masaki Norimoto, Donald Pizzo, E. Mantuano, Mahrou Sadri, Zixuan Wang, Daisy Chillin‐Fuentes, Sara Brin Rosenthal, Pardis Azmoon, S. Gonias, W. Campana   +12 more
semanticscholar   +1 more source