Results 231 to 240 of about 2,313,793 (272)

Neurotrophin Receptor TrkC Predicts Good Clinical Outcome in Medulloblastoma and Other Primitive Neuroectodermal Brain Tumors

Klinische Pädiatrie, 2000
Neurotrophins and their cognate receptors TrkA, TrkB and TrkC regulate proliferation, differentiation and death of neuronal progenitor cells and may be implicated in the progression of medulloblastoma and other primitive neuroectodermal brain tumors (PNET).
M A, Grotzer, A J, Janss, P C, Phillips, J Q, Trojanowski   +3 more
openaire   +2 more sources

Abstract 3036: The dependence receptor TrkC is a putative colon cancer tumor suppressor.

Cancer Research, 2013
Abstract Backgrounds & Aims: The TrkC neurotrophin receptor belongs to the functional dependence receptors family, members of which share the ability to induce apoptosis in the absence of their ligands. Such a trait has been hypothesized to confer tumor-suppressor activity. Indeed, cells that express these receptors are thought to be
Anne-Laure Genevois, G. Ichim, Marie-May Coissieux, Marie-Pierre Lambert, F. Lépinasse, Z. Herceg, J. Scoazec, S. Tauszig-Delamasure, P. Mehlen   +8 more
semanticscholar   +2 more sources

Recombinant adenovirus vector-mediated functional expression of neurotropin-3 receptor (TrkC) in neural stem cells

Experimental Neurology, 2007
We have constructed a recombinant adenovirus expression vector carrying the human neurotrophin-3 (NT-3) receptor TrkC (tyrosine protein kinase C) gene (rAd-TrkC; 2478 bp) and confirmed the expression of the encoded TrkC in green fluorescent protein (GFP)-murine neural stem cells (NSCs) by reverse transcription polymerase chain reaction (RT-PCR ...
Jun-Mei, Wang, Yuan-Shan, Zeng, Ran-Yi, Liu, Wen-Lin, Huang, Yi, Xiong, Yan-Hua, Wang, Shui-Jun, Chen, Yang D, Teng   +7 more
openaire   +2 more sources

Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas.

Cancer research, 1999
Elevated expression of the neurotrophin-3 (NT-3) receptor TrkC by childhood medulloblastomas is associated with favorable clinical outcome. Here, we provide evidence that TrkC is more than simply a passive marker of prognosis. We demonstrate that: (a) medulloblastomas undergo apoptosis in vitro when grown in the presence of NT-3; (b) overexpression of ...
J Y, Kim, M E, Sutton, D J, Lu, T A, Cho, L C, Goumnerova, L, Goritchenko, J R, Kaufman, K K, Lam, A L, Billet, N J, Tarbell, J, Wu, J C, Allen, C D, Stiles, R A, Segal, S L, Pomeroy   +14 more
openaire   +1 more source

Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation

Cellular Signalling, 2006
Tropomyosin-related kinase (Trk) family receptors are a group of high affinity receptors for neurotrophin growth factors, which have pivotal functions in many physiological processes of nervous system. Trk receptors can dimerize and autophosphorylate upon neurotrophin stimulation, then recruit multiple adaptor proteins to transduct signal.
Lei, Shi, Jiping, Yue, Yuangang, You, Bin, Yin, Yanhua, Gong, Caimin, Xu, Boqin, Qiang, Jiangang, Yuan, Yongjian, Liu, Xiaozhong, Peng   +9 more
openaire   +2 more sources

Co-expression of TrkB and TrkC receptors in CNS neurones suggests regulation by multiple neurotrophins

NeuroReport, 1995
Using double-label in situ hybridization, we have explored the possibility that individual CNS neurones can co-express mRNAs for the high-affinity receptors of brain-derived neurotrophic factor and neurotrophin-3, TrkB and TrkC, respectively. The vast majority of TrkC mRNA-containing neurones in the hippocampal formation and cerebral cortex were also ...
Z, Kokaia, M, Metsis, M, Kokaia, E, Elmér, O, Lindvall   +4 more
openaire   +2 more sources

Activation of the specific neurotrophin receptors TrkA, TrkB and TrkC influences the function of eosinophils

Clinical & Experimental Allergy, 2002
SummaryBackground Recent studies have shown that nerve growth factor (NGF) can act on several immune cells as well as residential cells. But little is known about their role in modulating eosinophil function via activation of high‐affinity receptors.Objectives The aim of this study was to assess whether eosinophils express functional receptors and if ...
O, Noga, C, Englmann, G, Hanf, A, Grützkau, S, Guhl, G, Kunkel   +5 more
openaire   +2 more sources

Regulation of neurotrophin and traka, trkb and trkc tyrosine kinase receptor messenger RNA expression in kindling

Neuroscience, 1993
Levels of messenger RNA for nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and the tyrosine kinase receptors trkA, trkB and trkC have been studied using in situ hybridization in the rat brain 2 h and four weeks after kindling-induced seizures.
Bengzon J., Kokaia Z., Ernfors P., Kokaia M., Leanza G., Nilsson O. G., Persson H., Lindvall O.   +7 more
openaire   +4 more sources

In Situ Hybridization of trkB and trkC Receptor mRNA in Rat Forebrain and Association with High‐affinity Binding of [125I]BDNF, [125I]NT‐4/5 and [125I]NT‐3

European Journal of Neuroscience, 1994
C. Altar, J. Siuciak, P. Wright, N. Ip, R. Lindsay, S. Wiegand   +5 more
semanticscholar   +1 more source

NT‐3‐mediated TrkC receptor activation promotes proliferation and cell survival of rodent progenitor oligodendrocyte cells in vitro and in vivo

Journal of Neuroscience Research, 1998
S. Kumar, M. Kahn, L. Dinh, J. de Vellis
semanticscholar   +1 more source