Results 21 to 30 of about 2,313,793 (272)

Pharmacological Co-Activation of TrkB and TrkC Receptor Signaling Ameliorates Striatal Neuropathology and Motor Deficits in Mouse Models of Huntington’s Disease

Journal of Huntington's Disease, 2023
Background: Loss of neurotrophic support in the striatum, particularly reduced brain-derived neurotrophic factor (BDNF) levels, contributes importantly to Huntington’s disease (HD) pathogenesis.
Danielle A. Simmons, Nadia P. Belichenko, Frank M. Longo   +2 more
openalex   +3 more sources

Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an advanced pathological stage

Neurobiology of Disease, 2022
Degeneration of basal forebrain cholinergic neurons (BFCNs) in the nucleus basalis of Meynert (NBM) and vertical diagonal band (VDB) along with their connections is a key pathological event leading to memory impairment in Alzheimer's disease (AD ...
Selena Gonzalez, Tyne L.M. McHugh, Tao Yang, Wassim Syriani, Stephen M. Massa, Frank M. Longo, Danielle A. Simmons   +6 more
doaj   +2 more sources

TrkC protects against osteoarthritis progression by maintaining articular cartilage homeostasis. [PDF]

Int J Biol Sci
Osteoarthritis (OA) is a degenerative disease with a series of metabolic changes accompanied by chondrocyte apoptosis. Chondrocytes express multiple receptors for neurotrophin, however, the role of neurotrophin receptor in chondrocyte metabolism remains ...
Chang Y, Kong K, Qiao H, Jin M, Wu X, Fan W, Zhang J, Qi Y, Xu Y, Qin A, Zhai Z, Li H.   +11 more
europepmc   +2 more sources

Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction

Neurobiology of Disease, 2006
Accumulating evidence has suggested that neurotrophins participate in the pathophysiology of mood disorders. We have developed transgenic mice overexpressing the full-length neurotrophin-3 receptor TrkC (TgNTRK3) in the central nervous system.
Mara Dierssen, Mònica Gratacòs, Ignasi Sahún, Miguel Martín, Xavier Gallego, Alejandro Amador-Arjona, María Martínez de Lagrán, Patricia Murtra, Eulalia Martí, Miguel A. Pujana, Isidre Ferrer, Esther Dalfó, Carmen Martínez-Cué, Jesús Flórez, Jesús F. Torres-Peraza, Jordi Alberch, Rafael Maldonado, Cristina Fillat, Xavier Estivill   +18 more
doaj   +3 more sources

The Neurotrophin Receptor TrkC as a Novel Molecular Target of the Antineuroblastoma Action of Valproic Acid [PDF]

International Journal of Molecular Sciences, 2021
Neurotrophins and their receptors are relevant factors in controlling neuroblastoma growth and progression. The histone deacetylase (HDAC) inhibitor valproic acid (VPA) has been shown to downregulate TrkB and upregulate the p75NTR/sortilin receptor ...
S. Dedoni, L. Marras, M. Olianas, A. Ingianni, P. Onali   +4 more
semanticscholar   +4 more sources

WITHDRAWN ARTICLE: NT-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons

EMBO Reports
Cancer patients undergoing treatment with antineoplastic drugs often experience chemotherapy-induced neuropathic pain (CINP), and the therapeutic options for managing CINP are limited. Here, we show that systemic paclitaxel administration upregulates the
Dilip Sharma, Xiaozhou Feng, Bing Wang, Bushra Yasin, Alex Bekker, Huijuan Hu, Yuan-Xiang Tao   +6 more
doaj   +2 more sources

Neurotrophin 3 (NTF3); neurotrophic tyrosine kinase receptor 3 (NTRK3; TrkC) [PDF]

Science-Business eXchange, 2010

openalex   +3 more sources

Runx3, Brn3a and Isl1 interplay orchestrates the transcriptional program in the early stages of proprioceptive neuron development. [PDF]

PLoS Genetics
BackgroundThe development and diversification of sensory proprioceptive neurons, which reside in the dorsal root ganglia (DRG) and express the tropomyosin receptor kinase C (TrkC), depend on the transcription factor (TF) Runx3.
Kira Orlovsky, Elena Appel, Shay Hantisteanu, Tsviya Olender, Joseph Lotem, Ditsa Levanon, Yoram Groner   +6 more
doaj   +2 more sources

The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm [PDF]

Proceedings of the National Academy of Sciences, 2007
The TrkC/NT-3 receptor/ligand pair is believed to be part of the classic neurotrophic theory claiming that neuronal death occurs by default when neurotrophic factors become limited, through loss of survival signals. Here, we show that TrkC is a dependence receptor and, as such, induces caspase-dependent apoptotic death in the absence of NT-3 in ...
S. Tauszig-Delamasure, Li-ying Yu, J. R. Cabrera, Jimena Bouzas-Rodríguez, Catherine Mermet-Bouvier, Catherine Guix, M. Bordeaux, U. Arumäe, P. Mehlen   +8 more
semanticscholar   +3 more sources

Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system [PDF]

The Journal of Neuroscience, 1994
The mammalian trkC gene encodes a tyrosine protein kinase that serves as a functional receptor for neurotrophin-3 (NT-3). Here, we report that trkC is widely expressed in the developing and adult nervous system. Using in situ hybridization, we first detect trkC transcripts in the telencephalon and spinal cord of embryonic day 9.5 mouse embryos.
Fabienne Lamballe, RJ Smeyne, Mariano Barbacid   +2 more
openalex   +4 more sources