Pyrazolo[1,5-a]pyrimidine as a Prominent Framework for Tropomyosin Receptor Kinase (Trk) Inhibitors-Synthetic Strategies and SAR Insights. [PDF]
MoleculesTropomyosin receptor kinases (Trks) are transmembrane receptor tyrosine kinases named TrkA, TrkB, and TrkC and encoded by the NTRK1, NTRK2, and NTRK3 genes, respectively.
Mahajan AT +5 more
europepmc +2 more sources
Neurotrophin Receptor TrkC Is an Entry Receptor for Trypanosoma cruzi in Neural, Glial, and Epithelial Cells [PDF]
Infection and Immunity, 2011 ABSTRACT Trypanosoma cruzi , the agent of Chagas' disease, infects a variety of mammalian cells in a process that includes multiple cycles of intracellular division and differentiation starting with host receptor recognition by a parasite ligand(s).
Craig Weinkauf +2 more
openalex +4 more sources
Bivalent Diketopiperazine-Based Tropomysin Receptor Kinase C (TrkC) Antagonists [PDF]
Journal of Medicinal Chemistry, 2010 Bivalent molecules containing two beta-turn mimics with side chains that correspond to hot-spots on the neurotrophin NT-3 were prepared. Binding assays showed the mimetics to be selective TrkC ligands, and biological assays showed one mimetic to be an antagonist of the TrkC receptor.
Jing Liu +3 more
openalex +4 more sources
Altered Primary Somatosensory Neuron Development in a Pten Heterozygous Model for Autism Spectrum Disorder. [PDF]
Autism ResABSTRACT Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social interactions, repetitive behaviors, and hyper‐ or hyposensitivity to sensory stimuli. The cellular mechanisms underlying the emergence of abnormal sensory sensitivity in ASD are not fully understood.
Fernandez A, Sarn N, Eng C, Wright KM.
europepmc +2 more sources
Trypanosoma cruziPromotes Neuronal and Glial Cell Survival through the Neurotrophic Receptor TrkC [PDF]
Infection and Immunity, 2009 ABSTRACTTrypanosoma cruzi, the agent of Chagas' disease, promotes neuron survival through receptor tyrosine kinase TrkA and glycosylphosphatidylinositol-anchored glial cell-derived family ligand receptors (GFRα). However, these receptors are expressed by only a subset of neurons and at low levels or not at all in glial cells. Thus,T. cruzimight exploit
Craig Weinkauf, Mercio PereiraPerrin
openalex +3 more sources
Dependence receptor TrkC is a putative colon cancer tumor suppressor [PDF]
Proceedings of the National Academy of Sciences, 2013 The TrkC neurotrophin receptor belongs to the functional dependence receptor family, members of which share the ability to induce apoptosis in the absence of their ligands. Such a trait has been hypothesized to confer tumor-suppressor activity. Indeed, cells that express these receptors are thought to be dependent on ligand availability for their ...
Anne-Laure Genevois +12 more
semanticscholar +3 more sources
Retardation of Hair Follicle Development by the Deletion of TrkC, High-Affinity Neurotrophin-3 Receptor [PDF]
Journal of Investigative Dermatology, 1999 Natalia V. Botchkareva +4 more
openalex +3 more sources
Proteins and signalling pathways targeted by dapagliflozin and finerenone: Insights from DAPA-CKD and FIGARO-DKD. [PDF]
Diabetes Obes MetabDiabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 750-753, January 2026.
de la Rambelje MA +4 more
europepmc +2 more sources
An ancient neurotrophin receptor code; a single Runx/Cbfβ complex determines somatosensory neuron fate specification in zebrafish. [PDF]
PLoS Genetics, 2017 In terrestrial vertebrates such as birds and mammals, neurotrophin receptor expression is considered fundamental for the specification of distinct somatosensory neuron types where TrkA, TrkB and TrkC specify nociceptors, mechanoceptors and proprioceptors/
Philia Gau +4 more
doaj +1 more source