Expression of Neurotrophins and Their Receptors Tropomyosin-related kinases (Trk) under Tension-stress during Distraction Osteogenesis [PDF]
, 2006 The localization and expression of neurotrophins and their receptors during distraction osteogenesis was investigated in 72 male rat femurs (11 weeks old) to further clarify the concurrence of cellular and molecular events of new bone formation.
Aiga, Ayako +6 more
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Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]
, 2011 Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell +39 more
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TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons. [PDF]
Genes & Development, 1996 The Trk family of protein tyrosine kinases (TrkA/B/C) are receptors for neurotrophins, a family of closely related proteins that are important physiological regulators of the survival of specific neurons within the peripheral nervous system (PNS) of vertebrates.
Liliana Minichiello, Rüdiger Klein
openalex +4 more sources
Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth.
PLoS Biology, 2018 The neurotrophin-3 (NT-3) receptor tropomyosin receptor kinase C (TrkC/NTRK3) has been described as a dependence receptor and, as such, triggers apoptosis in the absence of its ligand NT-3.
Marie Ménard +10 more
doaj +1 more source
Myelination: all about Rac n roll. [PDF]
, 2007 During the development of the peripheral nervous system, Schwann cells select individual axons from a nerve bundle and establish a one-to-one relationship through a process termed radial sorting. Recent findings identify the Rho family GTPase Rac1 as the
Chan, Jonah
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BMC Biology, 2010 Background The downstream of tyrosine kinase/docking protein (Dok) adaptor protein family has seven members, Dok1 to Dok7, that act as substrates of multiple receptor tyrosine kinase and non-receptor tyrosine kinase.
Yuan Jian +6 more
doaj +1 more source
Neurotrophins and neurotrophin receptors in proliferative diabetic retinopathy. [PDF]
PLoS ONE, 2013 Neurotrophins (NTs) are emerging as important mediators of angiogenesis and fibrosis. We investigated the expression of the NTs nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) and ...
Ahmed M Abu El-Asrar +8 more
doaj +1 more source
Runx3 is required for the specification of TrkC-expressing mechanoreceptive trigeminal ganglion neurons [PDF]
, 2010 Sensory neurons project axons to specific peripheral and central targets according to their sensory modality. Runx3 is crucially involved in proprioceptive dorsal root ganglion neuron development.
Ito Yoshiaki +7 more
core +1 more source
iScience, 2020 Summary: Events at a receptor ectodomain affect the intracellular domain conformation, activating signal transduction (out-to-in conformational effects).
Fouad Brahimi +9 more
doaj +1 more source
Functional Diversity of Neurotrophin Actions on the Oculomotor System [PDF]
, 2016 Neurotrophins play a principal role in neuronal survival and differentiation during development, but also in the maintenance of appropriate adult neuronal circuits and phenotypes.
Benítez Temiño, Beatriz +5 more
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