Results 151 to 160 of about 45,835 (229)

Validation of tRNA-derived fragments as diagnostic biomarkers in suspected acute stroke; limitations in analysis and quantification methods. [PDF]

Mol Ther Nucleic Acids
Woudenberg T, van der Bent ML, van den Homberg DAL, Nguyen TTM, Wermer MJH, van den Wijngaard IR, Quax PHA, Nossent AY, Kruyt ND.   +8 more
europepmc   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Extracellular vesicles-associated tRNA-derived fragments: Emerging insights into cancer progression and clinical application potential. [PDF]

Genes Dis
Pan Y, Zhang B, Li Z, Hu K.
europepmc   +1 more source

Mitochondrial DNA in Tumor Evolution and Heterogeneity: Characteristics, Technological Advances, Applications and Challenges

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review highlights mitochondrial DNA (mtDNA) somatic mutations as an emerging and potent endogenous lineage marker, offering distinct advantages over traditional nuclear genomic (nDNA) approaches. Lineage tracing based on mtDNA mutations has matured into an indispensable tool, providing unprecedented insights into tumor biology and holding ...
Zifeng Ruan, Zihao Chen, Weicheng Yu, Maolei Zhang, Xingguo Liu   +4 more
wiley   +1 more source

Sperm tRNA-derived fragments expression is potentially linked to abstinence-related improvement of sperm quality. [PDF]

Asian J Androl
Ji XR, Wang RJ, Huang ZH, Wu HL, Huang XH, Bo H, Lin G, Zhu WB, Huang C.   +8 more
europepmc   +1 more source

TRMT61A‐Mediated m1A Modification Suppresses FDX1 Translation to Drive Cuproptosis Evasion and Radioresistance in Hepatocellular Carcinoma

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This study identifies tRNA methyltransferase 61 A (TRMT61A)‐mediated N1‐methyladenosine (m1A) modification as a driver of radioresistance in hepatocellular carcinoma (HCC) by suppressing cuproptosis. TRMT61A methylates FDX1 mRNA, enabling YTHDF3 recognition and eRF1 recruitment to inhibit FDX1 translation.
Yunyun Xiao, Yue Li, Zelei Li, Rui Wang, Dongni Shi, Yanling Wen, Yibing Pan, Chen Lin, Junguo Bu, Libing Song, Hui Dai   +10 more
wiley   +1 more source

MAXTIA: A high‐throughput platform for rapid functional epitope mapping by kinetic screening of mutant libraries

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Accurate identification of epitope residues is essential for developing biopharmaceuticals and understanding the mechanisms of immune recognition. However, experimental approaches for residue‐level epitope mapping remain time‐consuming and labor‐intensive, while accurate computational prediction of protein–protein interfaces remains ...
Kihoon Kim, Ryo Matsunaga, Takanori Yokoo, Makoto Nakakido, Kouhei Tsumoto   +4 more
wiley   +1 more source

Changes in the Repertoire of tRNA-Derived Fragments in Different Blood Cell Populations. [PDF]

Life (Basel)
Artamonov AA, Kondratov KA, Bystritsky EA, Nikitin YV, Velmiskina AA, Mosenko SV, Polkovnikova IA, Asinovskaya AY, Apalko SV, Sushentseva NN, Ivanov AM, Scherbak SG.   +11 more
europepmc   +1 more source

Advances in large DNA fragment assembly for microbial cell factory engineering

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang, Wenqian Liu, Dongyuan Cheng, Jiazhang Lian, Xian Fu, Yue Shen   +5 more
wiley   +1 more source

A general framework to over-express tRNA-derived fragments from their parental tRNAs in mammalian cells. [PDF]

Methods Enzymol
Esmaeili F, Banerjee K, Su Z, Dutta A.
europepmc   +1 more source