Results 111 to 120 of about 234,592 (250)

Characterization of leucyl-TRNA synthetase from homo sapiens and escherichia coli in aminoacylation, amino acid editing and interdomain interactions [PDF]

open access: yes, 2010
Aminoacyl-tRNA synthetases (aaRSs) are ancient enzymes that charge tRNA with its cognate amino acid. In order to maintain fidelity during protein synthesis, editing mechanisms ensure that tRNAs are accurately charged. Leucyl-tRNA synthetase (LeuRS) has
Pang, Yan Ling Joy
core  

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

open access: yesChemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Koordinace vzdělávacích cílů v Občanské a Základní škole

open access: yesPedagogická Orientace, 2018
N ...
Josef Trna, Eva Trnová
doaj  

Assessment of Attainable Distances in Proteins by Through‐Space 19F–19F Couplings

open access: yesChemistry – A European Journal, EarlyView.
De novo synthesized difluorinated tryptophan analogues are site‐specifically incorporated into Cyclophilin A (CypA). 19F–19F NOESY build‐up experiments are recorded for each labeled protein, and the distances derived from cross‐relaxation rates are compared to reference distances.
Iker Hernández   +6 more
wiley   +1 more source

Development of an in vivo tryptofanyl-tRNA synthetase inhibition assay

open access: yes
Aminoacil-tRNA-sintetaze (AaRS), predstavljaju dobru metu za razvoj novih antibiotika, jer postoje značajne razlike između evolucijski očuvanih prokariotskih i eukariotskih enzima.
Subota, Kristian
core   +2 more sources

Das Regensburger Symposium : ein Bericht

open access: yesBrünner Beiträge zur Germanistik und Nordistik, 2017
Jan Trna
doaj   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

open access: yesChemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi   +6 more
wiley   +1 more source

In Sloterdijks Weltinnenraum : ein Konferenzbericht

open access: yesBrünner Beiträge zur Germanistik und Nordistik, 2017
Jan Trna
doaj   +1 more source

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

open access: yesCytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith   +9 more
wiley   +1 more source

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