Results 131 to 140 of about 234,592 (250)

Targeting eEF1A1 With Baicalein to Block eEF1A1/Prdx4 Interaction for Treating Sepsis‐Mediated Lung Injury

Exploration, EarlyView.
Targeting eEF1A1 with baicalein disrupts the eEF1A1‐Prdx4 interaction to prevent RNF14‐mediated ubiquitination and degradation of Prdx4. This stabilizes Prdx4 to suppress NF‐κB, thereby alleviating sepsis‐induced acute lung injury. ABSTRACT Sepsis is a systemic inflammatory response syndrome triggered by an uncontrolled host response to infection ...
Jing Chang, Hui‐Lin Zhang, Qi‐Meng Zhu, Si‐Wen Hui, Xin‐Rong Xu, Mahmood Brobbey Oppong, Yan‐Li Feng, Juan Zhang, Cheng‐Peng Sun, Feng Qiu   +9 more
wiley   +1 more source

"Meine Lehre aus der Geschichte ist keine optimistische" : Interview mit der österreichischen Schriftstellerin Eva Menasse

Brünner Beiträge zur Germanistik und Nordistik, 2023
Jan Trna, Eva Menasse
doaj   +1 more source

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

Suizid und Literatur : Einleitung

Brünner Beiträge zur Germanistik und Nordistik, 2022
Erkan Osmanović, Jan Trna
doaj   +1 more source

Ashwin and FAM98 paralogs define nuclear and cytoplasmic RNA ligase complexes for tRNA biogenesis. [PDF]

Nat Commun
Kleinwächter M, Moser M, Raynaud N, Pfleiderer MM, Jinek M, Martinez J.   +5 more
europepmc   +1 more source

Structural framework for the assembly of the human tRNA ligase complex. [PDF]

Nat Commun
Pfleiderer MM, Kleinwächter M, Nievergelt AS, Boneberg FM, Kroupova A, Martinez J, Jinek M.   +6 more
europepmc   +1 more source

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng, Xiao Han, Congquan Wu, Qiaowen Lu, Shujun Gao   +4 more
wiley   +1 more source

Dietary effects on cytosolic and mitochondrial tRNA abundance and modification patterns across mouse tissues. [PDF]

Genome Res
Liu S, Holmes AD, Zhao R, Herbert C, Limbach PA, Lowe TM, Sharma U.   +6 more
europepmc   +1 more source

N6‐Methyladenosine in Inflammatory Bowel Disease: An Emerging Regulator of Pathogenesis and a Novel Therapeutic Frontier

iMetaMed, EarlyView.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo, Yang Zhang, Xin Wang, Shan Cao, Jun Xu   +4 more
wiley   +1 more source

Molecular basis of tRNA substrate recognition and modification by the atypical SPOUT methyltransferase Trm10. [PDF]

Nucleic Acids Res
Nandi S, Strassler SE, Dey D, Whitney CB, Roumaya OB, Krishnamohan A, Harris GM, Comstock LR, Jackman JE, Conn GL.   +9 more
europepmc   +1 more source