Results 121 to 130 of about 241,053 (344)

Biogenesis and functions of aminocarboxypropyluridine in tRNA

Nature Communications, 2019
Transfer (t)RNAs contain a wide variety of post-transcriptional modifications, which play critical roles in tRNA stability and functions. 3-(3-amino-3-carboxypropyl)uridine (acp3U) is a highly conserved modification found in variable- and D-loops of ...
M. Takakura, Kensuke Ishiguro, Shinichiro Akichika, K. Miyauchi, Tsutomu Suzuki   +4 more
semanticscholar   +1 more source

Ubc9‐Mediated SUMOylation of RPL3, an Unappreciated Mechanism against Hepatocyte Senescence by Repressing the DHX9‐p16 Axis

Advanced Science, EarlyView.
Liver aging is characterized by a decline in the expression of the SUMO‐conjugating enzyme Ubc9, resulting in reduced SUMOylation levels in hepatocytes, particularly in the case of ribosomal protein RPL3. Disruption of RPL3 SUMOylation increases its nuclear translocation. Interestingly, ribosome‐free RPL3 facilitates the recruitment of helicase DHX9 to
Hao Xie, Zhichao Gao, Xin Liu, Shiyi Zhang, Yuhan Wang, Jia Gao, Ping Qi, Lu Zhang, Jiawei Zhao, Tian Xiong, Teng Huang, Jia Song, Qilin Yu, Shu Zhang, Yanjun Liu, Ping Yang, Maryam S. Al‐Motawa, Quan Gong, Junfeng Dong, Hao Yin, Fei Sun, Shiwei Liu, Cong‐Yi Wang   +22 more
wiley   +1 more source

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Nucleic Acids Research, 2018
Transfer RNAs (tRNAs) are non-coding RNA molecules essential for protein synthesis. Post-transcriptionally they are heavily modified to improve their function, folding and stability.
C. Cosentino, Sanna Toivonen, Esteban Diaz Villamil, M. Atta, J. Ravanat, Stéphane Demine, A. Schiavo, Nathalie Pachera, Jean-Philippe Deglasse, J. Jonas, Diego Balboa, T. Otonkoski, E. Pearson, P. Marchetti, D. Eizirik, M. Cnop, M. Igoillo-Esteve   +16 more
semanticscholar   +1 more source

Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein

Advanced Science, EarlyView.
A CRISPR‐free mitochondrial RNA m1A demethylation (MRD) editor combining MTS, PUF proteins, and ALKBH3 enables precise m1A removal from mitochondrial mRNA and tRNA, which influences mitochondrial protein levels, cellular proliferation, ATP production, and mitochondrial respiration. Subsequently, in vivo demethylation of the m1A modification is achieved
Xiangrui Li, Deqiang Kong, Hongmei Liu, Jie Yang, Jiale Zhou, Yuqiang Qian, Ding Zhao, Jinze Li, Xinyu Wu, Tao Zhang, Xiaodi Sun, Yang Han, Liangxue Lai, Zhanjun Li   +13 more
wiley   +1 more source

Didaktika fyzika a psychologie

Pedagogická Orientace, 2018
N ...
Josef Trna
doaj  

Tyll in Brünn: zwischen Gauklern und Mineuren : ein literaturwissenschaftliches und fremdsprachendidaktisches Unterrichtskonzept zu Daniel Kehlmanns Roman in 20 Aufgaben

Brünner Beiträge zur Germanistik und Nordistik, 2019
This paper aims to treat the latest novel TYLL by Daniel Kehlmann with an approach of literary studies as well as to make it didactically useful. With regard to the didactic approach, this contribution seeks to offer literary (recommended) instructions ...
Johannes Köck, Jan Trna
doaj   +1 more source

Review

, 2020
The chalcogen elements oxygen, sulfur, and selenium are essential constituents of side chain functions of natural amino acids. Conversely, no structural and biological function has been discovered so far for the heavier and more metallic tellurium ...
Agh R, Arai K, Baskakov IV, Creighton TE, Dittmer K, Du Vigneaud V, Janeček J, Metanis N, Musiol HJ, Muttenthaler M, Nygard B, O'Donnell ME, Welch M, Yang F   +13 more
core   +1 more source

tRNA Metabolism and Neurodevelopmental Disorders.

Annual review of genomics and human genetics (Print), 2019
tRNAs are short noncoding RNAs required for protein translation. The human genome includes more than 600 putative tRNA genes, many of which are considered redundant.tRNA transcripts are subject to tightly controlled, multistep maturation processes that ...
A. Schaffer, Otis Pinkard, Jeff Coller
semanticscholar   +1 more source

Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma

Advanced Science, EarlyView.
Lactylation, linked to glycolysis, is poorly understood in regulation. It is found that LDHA is lactylated at Lys81/Lys318 by AARS1, boosting its activity and cellular lactylation via positive feedback in LUAD. Lactylation regulates NHEJ‐related proteins; their delactylation impairs NHEJ and increases cisplatin sensitivity, offering anticancer insights.
Jizhuo Li, Wenze Xun, Xijie Wang, Ruiguang Luo, Qifan Hu, Zhaocai Zhou, Jian Yuan, Yanan Wang, Xiaorui Wan, Tao Zhao, Tianyu Han, Jian‐Bin Wang   +11 more
wiley   +1 more source

Konstrukční výzkum (design-based research) v přírodovědných didaktikách

Scientia in Educatione, 2013
Teoretická studie s praktickou ukázkou prezentuje konstrukční výzkum (angl. design-based research) v přírodovědných didaktikách. V první části jsou vymezeny pojmy konstrukční přístup a konstrukční výzkum. Konstrukční výzkum je novým trendem v didaktickém
Josef Trna
doaj