Results 191 to 200 of about 324,922 (336)

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

open access: yesMass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

The polyamino‐isoprenyl enhancer NV716 enables the antibacterial activity of two families of multi‐target inhibitors against the ESKAPEE bacterium Enterobacter cloacae

open access: yesmLife, EarlyView.
Abstract Gram‐negative bacteria are particularly prone to developing antimicrobial resistance (AMR), as evidenced by the WHO's ESKAPEE list of high‐priority pathogens. One strategy that has increased is the use of antibiotic enhancers, which can re‐empower abandoned or poorly active antibiotics against the resistant strain of interest.
Emma Forest   +11 more
wiley   +1 more source

Machine Learning‐Based High‐Throughput Screening, Molecular Modeling and Quantum Chemical Analysis to Investigate Mycobacterium tuberculosis MetRS Inhibitors

open access: yesChemistryOpen, EarlyView.
This paper provides a comprehensive approach using the ChEMBL database to construct a machine learning model that screened 10 million compounds from the eMolecules database. Two promising inhibitors targeting Mycobacterium tuberculosis methionyl‐tRNA synthetase were identified.
Rajesh Maharjan   +7 more
wiley   +1 more source

The complete mitogenome of Hyalomma anatolicum: novel insights into the phylogenetics of Hyalomma. [PDF]

open access: yesParasitol Res
Che J   +9 more
europepmc   +1 more source

Microbiota diversity and differences in the respiratory tract of children with pneumonia

open access: yesPediatric Investigation, EarlyView.
Differences in microbial communities in the upper and lower respiratory tract in patients with pneumonia were investigated in this study by sequencing the 16S rRNA genes in pharyngeal swabs and alveolar lavage fluid. Forty‐three subjects were enrolled in the study, and one upper and one lower respiratory tract sample were collected from each subject ...
Dandan Ge   +4 more
wiley   +1 more source

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