Results 21 to 30 of about 345,668 (351)
tRNA Recognition by Glutamyl-tRNA Reductase [PDF]
Journal of Biological Chemistry, 2004 During the first step of porphyrin biosynthesis in Archaea, most bacteria, and in chloroplasts glutamyl-tRNA reductase (GluTR) catalyzes the NADPH-dependent reduction of glutamyl-tRNA to glutamate-1-semialdehyde. Elements in tRNA(Glu) important for utilization by Escherichia coli GluTR were determined by kinetic analysis of 51 variant transcripts of E.
Lennart, Randau +8 more
openaire +2 more sources
tRNA Fragments Populations Analysis in Mutants Affecting tRNAs Processing and tRNA Methylation [PDF]
Frontiers in Genetics, 2020 tRNA fragments (tRFs) are a class of small non-coding RNAs (sncRNAs) derived from tRNAs. tRFs are highly abundant in many cell types including stem cells and cancer cells, and are found in all domains of life. Beyond translation control, tRFs have several functions ranging from transposon silencing to cell proliferation control.
Molla-Herman, Anahi +5 more
openaire +3 more sources
Evolution of Life on Earth: tRNA, Aminoacyl-tRNA Synthetases and the Genetic Code
Life, 2020 Life on Earth and the genetic code evolved around tRNA and the tRNA anticodon. We posit that the genetic code initially evolved to synthesize polyglycine as a cross-linking agent to stabilize protocells. We posit that the initial amino acids to enter the
Lei Lei, Zachary F Burton
doaj +1 more source
Mutually orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs [PDF]
Nature Chemistry, 2018 Genetically encoding distinct non-canonical amino acids (ncAAs) into proteins synthesized in cells requires mutually orthogonal aminoacyl-tRNA synthetase (aaRS)/tRNA pairs. The pyrrolysyl-tRNA synthetase/PyltRNA pair from Methanosarcina mazei (Mm) has been engineered to incorporate diverse ncAAs and is commonly considered an ideal pair for genetic code
Julian C. W. Willis, Jason W. Chin
openaire +2 more sources
DEREGULATED EXPRESSIONS OF MYC ALTER THE EXPRESSIONS OF tRNAS IN BREAST CANCER CELLS
Sabiad, 2023 Objective: The protein synthesis process is started with DNA being transcribed into mRNA in the nucleus, then mRNA is transported to the cytoplasm and attaches to a ribosome in order to be translated into a protein.
Pervin Elvan Tokgün, Onur Tokgün
doaj +1 more source
RNA Biology, 2022 Delicate variances in the translational machinery affect how efficiently different organisms approach protein synthesis. Determining the scale of this effect, however, requires knowledge on the differences of mistranslation levels.
Karl Jürgenstein +5 more
doaj +1 more source
Initiator tRNA genes template the 3\u27 CCA end at high frequencies in bacteria. [PDF]
, 2016 BACKGROUND: While the CCA sequence at the mature 3\u27 end of tRNAs is conserved and critical for translational function, a genetic template for this sequence is not always contained in tRNA genes.
Ardell, David H., Hou, Ya-Ming
core +3 more sources
Phenylalanyl‐tRNA, Lysyl‐tRNA, Isoleucyl‐tRNA and Arginyl‐tRNA Synthetases [PDF]
European Journal of Biochemistry, 1980 Ten analogs of ATP have been tested in the ATP/PPi exchange reaction of Phenylalanyl‐tRNA, lysyl‐tRNA, isoleucyl‐tRNA and arginyl‐tRNA synthetases from baker's yeast. Three compounds are substrates for Phenylalanyl‐tRNA, seven for lysyl‐tRNA, two for isoleucyl‐tRNA and five for arginyl‐tRNA synthetase. Their Km and V values have been determined.
W, Freist, F, Cramer
openaire +2 more sources
Nature Communications, 2017 Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the
Youngzee Song +10 more
doaj +1 more source
Cysteinyl‐tRNA formation and prolyl‐tRNA synthetase
FEBS Letters, 2002 Aminoacyl‐tRNA (AA‐tRNA) formation is a key step in protein biosynthesis. This reaction is catalyzed with remarkable accuracy by the AA‐tRNA synthetases, a family of 20 evolutionarily conserved enzymes. The lack of cysteinyl‐tRNA (Cys‐tRNA) synthetase in some archaea gave rise to the discovery of the archaeal prolyl‐tRNA (Pro‐tRNA) synthetase, an ...
Jacquin-Becker, Clarisse +5 more
openaire +3 more sources