Results 21 to 30 of about 404,299 (351)
Small regulatory RNAs: from bench to bedside – a keystone symposia meeting report
RNA Biology, 2023 The Keystone Symposium ‘Small Regulatory RNAs: From Bench to Bedside’ was held in Santa Fe, New Mexico from May 1–4, 2022. The symposium was organized by Frank J. Slack, Jörg Vogel, Ivan Martinez and Karyn Schmidt, and brought together scientists working
Soo Mi Lee +3 more
doaj +1 more source
Direct Nanopore Sequencing of Individual Full Length tRNA Strands
bioRxiv, 2021 We describe a method for direct tRNA sequencing using the Oxford Nanopore MinION. The principal technical advance is custom adapters that facilitate end-to-end sequencing of individual tRNA molecules.
Niki Thomas +5 more
semanticscholar +1 more source
Evolution of Life on Earth: tRNA, Aminoacyl-tRNA Synthetases and the Genetic Code
Life, 2020 Life on Earth and the genetic code evolved around tRNA and the tRNA anticodon. We posit that the genetic code initially evolved to synthesize polyglycine as a cross-linking agent to stabilize protocells. We posit that the initial amino acids to enter the
Lei Lei, Zachary F Burton
doaj +1 more source
RNA: A publication of the RNA Society, 2020 The aminoacyl-tRNA synthetases are an essential and universally distributed family of enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate amino acids for decoding mRNAs according to the genetic code. Synthetases help
Miguel Angel Rubio Gomez, M. Ibba
semanticscholar +1 more source
Noncanonical Roles of tRNAs: tRNA Fragments and Beyond.
Annual Review of Genetics, 2020 As one of the most abundant and conserved RNA species, transfer RNAs (tRNAs) are well known for their role in reading the codons on messenger RNAs and translating them into proteins. In this review, we discuss the noncanonical functions of tRNAs.
Zhangli Su +3 more
semanticscholar +1 more source
Initiator tRNA genes template the 3\u27 CCA end at high frequencies in bacteria. [PDF]
, 2016 BACKGROUND: While the CCA sequence at the mature 3\u27 end of tRNAs is conserved and critical for translational function, a genetic template for this sequence is not always contained in tRNA genes.
Ardell, David H., Hou, Ya-Ming
core +3 more sources
Quantitative tRNA-sequencing uncovers metazoan tissue-specific tRNA regulation
Nature Communications, 2020 Transfer RNAs (tRNA) are quintessential in deciphering the genetic code; disseminating nucleic acid triplets into correct amino acid identity. While this decoding function is clear, an emerging theme is that tRNA abundance and functionality can ...
Otis Pinkard +3 more
semanticscholar +1 more source
Nature Communications, 2017 Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the
Youngzee Song +10 more
doaj +1 more source
Sri Lankan Journal of Infectious Diseases, 2014 Introduction: The complete mitochondrial (mt) genomes of nematodes sequenced thus far are circular and small in length, containing 37 genes, including 12–13 protein-coding genes: namely, cytochrome oxidase subunits 1–3 (cox1–3), nicotinamide adenine ...
S Wickramasinghe, L Yatawara, T Agatsuma
doaj +1 more source