YAMAT-seq: an efficient method for high-throughput sequencing of mature transfer RNAs. [PDF]
, 2017 Besides translation, transfer RNAs (tRNAs) play many non-canonical roles in various biological pathways and exhibit highly variable expression profiles.
Honda, Shozo +5 more
core +2 more sources
Exosomal tRNA-derived small RNA as a promising biomarker for cancer diagnosis
Molecular Cancer, 2019 tRNA-derived small RNA (tsRNA) is a novel regulatory small non-coding RNA and participates in diverse physiological and pathological processes. However, the presence of tsRNAs in exosome and their diagnostic potential remain unclear.
Lei Zhu +11 more
semanticscholar +1 more source
Mitochondrial DNA. Part B. Resources, 2020 Catla (Catla catla) is one of the fastest-growing major carp found in South Asia as well as Bangladesh. Catla catla is the second most popular indigenous carp species in the freshwater aquaculture industry of Bangladesh due to its relatively good taste ...
M. M. Kibria +5 more
doaj +1 more source
Principles of Palliative and Supportive Care in Pancreatic Cancer: A Review
Biomedicines, 2023 Pancreatic adenocarcinoma (PDAC) is well known for its poor survival time. Clinical symptoms are painless jaundice or abdominal or back pain. Less specific symptoms often appear that make diagnosis difficult, e.g., weight loss, loss of appetite, nausea ...
Robert Mazur, Jan Trna
doaj +1 more source
Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs
Nucleic Acids Research, 2018 Transfer RNA is heavily modified and plays a central role in protein synthesis and cellular functions. Here we demonstrate that ALKBH3 is a 1-methyladenosine (m1A) and 3-methylcytidine (m3C) demethylase of tRNA.
Zhuojia Chen +9 more
semanticscholar +1 more source
Coordination of tRNA nuclear export with processing of tRNA [PDF]
RNA, 1999 Eukaryotic tRNAs are synthesized in the nucleus and need to be exported to the cytoplasm where they function in translation. tRNA export is mediated by exportin-t, which binds tRNA directly and with high affinity. tRNAs are initially synthesized as precursor molecules.
Lipowsky, G. +7 more
openaire +3 more sources
RNA: A publication of the RNA Society, 2018 tRNA related RNA fragments (tRFs), also known as tRNA-derived RNAs (tdRNAs), are abundant small RNAs reported to be associated with Argonaute proteins, yet their function is unclear.
Canan Kuscu +5 more
semanticscholar +1 more source
The stress specific impact of ALKBH1 on tRNA cleavage and tiRNA generation
bioRxiv, 2020 tiRNAs are small non-coding RNAs produced when tRNA is cleaved under stress. tRNA methylation modifications has emerged in recent years as important regulators for tRNA structural stability and sensitivity to cleavage and tiRNA generation during stress ...
Sherif Rashad +6 more
semanticscholar +1 more source
Aminoacyl tRNA synthetase complex interacting multifunctional protein 1 simultaneously binds Glutamyl-Prolyl-tRNA synthetase and scaffold protein aminoacyl tRNA synthetase complex interacting multifunctional protein 3 of the multi-tRNA synthetase complex [PDF]
, 2018 Higher eukaryotes have developed extensive compartmentalization of amino acid (aa) - tRNA coupling through the formation of a multi-synthetase complex (MSC) that is composed of eight aa-tRNA synthetases (ARS) and three scaffold proteins: aminoacyl tRNA ...
Bartlett, Seamus +2 more
core +1 more source
tRNA-Derived Small RNA: A Novel Regulatory Small Non-Coding RNA
Genes, 2018 Deep analysis of next-generation sequencing data unveils numerous small non-coding RNAs with distinct functions. Recently, fragments derived from tRNA, named as tRNA-derived small RNA (tsRNA), have attracted broad attention. There are mainly two types of
Siqi Li, Zhengping Xu, J. Sheng
semanticscholar +1 more source