Results 151 to 160 of about 110,116 (296)

Multi‐Tissue Omics Analysis Uncovers Translational Regulation Underlying Complex Traits in Pigs

Advanced Science, EarlyView.
Integrated multi‐omics across pig breeds and tissues reveals key principles of post‐transcriptional translational regulation and their contribution to trait formation. A gene network framework integrating transcriptomic and translatomic data is developed and applied to elucidate the genetic basis of meat production, offering new insights into mammalian
Chao Wang, Yuanyuan Zhang, Choulin Chen, Xiaoxian Xu, Shenghua Qin, Junyan Qi, Yongzhou Bao, Huiming Li, Ruipu Chen, Weigang Zheng, Zhilong Chen, Lingzhao Fang, Yunxiang Zhao, Yuwen Liu   +13 more
wiley   +1 more source

P1250: TRNA METHYLTRANSFERASE DNMT2 MODULATES GVHD PROCESS VIA TRNA M5C MODIFICATION

HemaSphere, 2023
MA Chao, Huanping Guo, Rui Wang, Ting Chen, Yunjing Zeng, Shengwang Wu, Shijie Yang, Yunfang Zhang, XI Zhang   +8 more
doaj   +1 more source

Phylogenetic systematics of Juncaceae

American Journal of Botany, EarlyView.
Abstract Premise Juncaceae has needed taxonomic revision for some time. Specifically, the genus Juncus s.l. is known to be paraphyletic because five small southern‐hemisphere genera have been shown repeatedly to be nested within it. In 2022, a new classification was proposed, based on phylogenies built from one nuclear and three plastid regions ...
Reed J. Kenny, Lenka Záveská Drábková, Daniel Potter   +2 more
wiley   +1 more source

Identification of the prebiotic translation apparatus within the contemporary ribosome [PDF]

, 2009
A structural element that could have existed independently in the prebiotic era was identified at the active site of the contemporary ribosome. It is suggested to have functioned as a proto-ribosome catalyzing peptide bond formation and non-coded ...
Ada Yonath, Anat Bashan, Chen Davidovich, Ilana Agmon   +3 more
core   +1 more source

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Decoding tRNA dynamics in neuroimmune disorders: mechanistic insights, diagnostic innovations, and therapeutic opportunities

Frontiers in Immunology
Transfer RNA (tRNA) and its derivatives, once regarded solely as translational adaptors, are now recognized as pivotal regulators of neuroimmune homeostasis.
Enlin Liang, Enlin Liang, Wenya Wang, Wenya Wang, Li Zhang, Li Zhang   +5 more
doaj   +1 more source

The modification landscape ofP. aeruginosatRNAs

RNA modifications have a substantial impact on tRNA function, with modifications in the anticodon loop contributing to translational fidelity and modifications in the tRNA core impacting structural stability. In bacteria, tRNA modifications are crucial for responding to stress and regulating the expression of virulence factors.
Mariana D. Mandler, Siddhardha S. Maligireddy, Wilfried M. Guiblet, Christina M. Fitzsimmons, Kayla S. McDonald, Delayna L. Warrell, Pedro J. Batista   +6 more
openaire   +2 more sources

Phylogenomics and Biogeography of the Eastern Asian–Eastern North American Disjunct Genus Hylodesmum (Fabaceae)

Biological Diversity, EarlyView.
Integrating data from plastid genomes, nrDNA, and 353 low‐copy nuclear genes, this study establishes a robust phylogenetic framework for Hylodesmum. This framework supports a taxonomic revision recognizing 18 species and reveals a complex pattern of bidirectional EA–ENA dispersal, with mammals as a plausible dispersal agent. ABSTRACT Phylogenomics with
Zhuqiu Song, Gang Yao, Chen Ren, Kaiwen Jiang, Dongxian Xu, Shijin Li   +5 more
wiley   +1 more source

One‐Step and Universal Strategy for the Synthesis of Hypermodified Uracil Phosphoramidites acp3U and cmnm5U

Chemistry – A European Journal, EarlyView.
One‐step, highly efficient, and scalable synthesis of acp3U phosphoramidite is described, as well as a new alternative synthesis of cmnm5U phosphoramidite from a highly versatile intermediate. Latter could be scaled‐up, split, and aliquots turned simultaneously into cmnm5U, nm5U, and mnm5U.
Ewa Mejdr, Lena Heinickel, Thomas Carell, Ivana Mejdr   +3 more
wiley   +1 more source