Results 171 to 180 of about 764 (211)
Molecular Microbiology, EarlyView.A chromosomal mutation allows bypass of deletion of the Escherichia coli fabH gene. The bypass results from creation of a new promoter that drives increased madA transcription, resulting in increased synthesis of acetyl‐acyl carrier protein by decarboxylation of malonyl‐acyl carrier protein.
Qiaoqiao Guo +5 more
wiley +1 more source
Molecular Microbiology, EarlyView.AGXX enhances aminoglycoside activity against multidrug‐resistant pathogens such as uropathogenic Escherichia coli by increasing reactive oxygen species, causing protein aggregation and DNA damage. This effect is reduced by oxygen limitation or antioxidants. Polyphosphate protects cells from oxidative damage.
Emmanuel P. Oladokun +9 more
wiley +1 more source
A Spontaneous Mutation in tfoX Impairs Bioluminescence in Photobacterium kishitanii ANT‐2200
Molecular Microbiology, EarlyView.A frameshift mutation in tfoX generates a truncated regulator associated with reduced lux–rib expression and low luminescence. Complementation with wild‐type tfoX restores transcription and light production, supporting a role for TfoX in regulating bioluminescence independently of quorum sensing.
Capucine Le Cam Ligier +6 more
wiley +1 more source
Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum
Molecular Microbiology, EarlyView.During asexual blood‐stage development, P. falciparum Sec14 proteins display distinct localizations suggesting specialized roles in lipid exchange. PfSec14‐1 initially localizes to the nucleus before moving to the ER and Golgi alongside PfSec14‐4 during schizogony.
Florian Lauruol +5 more
wiley +1 more source
microRNA‐mediated control of cell fate specification and patterning in Marchantia polymorpha
New Phytologist, EarlyView.The gemma developmental program in Marchantia polymorpha is coordinated by MpMIR166‐mediated repression of MpC3HDZ and auxin homeostasis. Summary MicroRNAs (miRNAs) are small non‐coding RNA molecules essential for growth and development in eukaryotes. In plants, the master gene DICER‐LIKE 1 (DCL1) catalyzes the biogenesis of miRNAs by processing double‐
Adolfo Aguilar‐Cruz +17 more
wiley +1 more source
Cross‐kingdom RNA interference as a unifying mechanism in plant–microbe interactions
New Phytologist, EarlyView.
Summia Gul, An‐Po Cheng
wiley +1 more source
New FLU mutant alleles point to new insights into singlet oxygen‐mediated signal transduction
New Phytologist, EarlyView.
Bernhard Grimm
wiley +1 more source
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tRNA modifications and islet function
Diabetes, Obesity and Metabolism, 2018Efficient and accurate protein translation is essential to producing insulin in pancreatic β‐cells. Transfer RNA (tRNA) is known as the key component of the protein translational machinery. Interestingly, tRNA contains a wide variety of chemical modifications, which are posttranscriptionally catalysed by tRNA modifying enzymes.
Fan‐Yan Wei, Kazuhito Tomizawa
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Cooperativity between different tRNA modifications and their modification pathways
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2018Ribonucleotide modifications perform a wide variety of roles in synthesis, turnover and functionality of tRNA molecules. The presence of particular chemical moieties can refine the internal interaction network within a tRNA molecule, influence its thermodynamic stability, contribute novel chemical properties and affect its decoding behavior during mRNA
Mikołaj Sokołowski +4 more
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Patterns of Base Modification in tRNA
Nature New Biology, 1973WE have previously demonstrated that the N-hydroxy-succinimide ester of phenoxyacetic acid (HSP) reacts with certain species of rat liver tRNA1. The reactive species were identified by an alteration in their elution pattern on benzoylated DEAE-cellulose chromatography.
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