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Role of tRNA modification in translational fidelity
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1990In transfer RNA many different modified nucleosides are found, especially in the anticodon region. In this region, pseudouridine (psi) is found in positions 38, 39 or 40 in a subset of tRNA species, 2-methylthio-6-hydroxyisopentenyladenosine (ms2io6A) is found in position 37 in tRNAs that read codons starting with U and 1-methylguanosine (m1G) is found
T G, Hagervall +4 more
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tRNA modifications and their potential roles in pancreatic cancer
Archives of Biochemistry and Biophysics, 2021Since the breakthrough discovery of N6-methyladenosine (m6A), the field of RNA epitranscriptomics has attracted increasing interest in the biological sciences. Transfer RNAs (tRNAs) are extensively modified, and various modifications play a crucial role in the formation and stability of tRNA, which is universally required for accurate and efficient ...
Hua Huang +4 more
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Role of tRNA modifications in human diseases
Trends in Molecular Medicine, 2014Transfer RNAs (tRNAs) are key for efficient and accurate protein translation. To be fully active, tRNAs need to be heavily modified post-transcriptionally. Growing evidence indicates that tRNA modifications and the enzymes catalyzing such modifications may play important roles in complex human pathologies.
Adrian Gabriel, Torres +2 more
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tRNA Modification: Is Cancer Having a Wobble?
Trends in Cancer, 2017Translational control of protein synthesis supports tumor development and progression to metastasis. Wobble tRNA modifications are required during translation elongation and sustain proteome homeostasis. Recent work has highlighted the surprising upregulation of the wobble uridine 34 (U34) tRNA cascade in cancer, which underlies the specific ...
Rapino, Francesca +4 more
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Dynamic Regulation of tRNA Modifications in Cancer
2018Transfer RNAs are decorated by chemical modifications of their nucleosides. These modifications affect all aspects of tRNA biology including translation and tRNA turnover. Interestingly, it was discovered decades ago that levels of modified tRNA nucleosides are changed in cancer patients and that the activity of modifying enzymes varies along with an ...
Close, Pierre +3 more
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[18] Modification of tRNA's by bromination
1971Publisher Summary This chapter discusses the modification of tRNAs through bromination. Among the major bases in tRNA, uracil and cytosine are most susceptible to bromination at room temperature and pH 5.4. Guanine is much less reactive, and adenine is completely resistant to bromination under these experimental conditions, or when the reaction is ...
P.C. Zamecnik, C.T. Yu
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[17] Modification of tRNA with ethylenimine
1971Publisher Summary This chapter describes the chemical modifications of Escherichia coli B tRNA with ethylenimine, which inhibits the ability of E.coli B tRNA to accept certain amino acids. Exposure of unfractionated E. coli B tRNA to ethylenimine at pH 8.0 leads to the aminoethylation of SUMP and GMP residues, and the rate of alkylation of these ...
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Dynamic tRNA Modification Landscape
2016Eukaryotic tRNAs contain on average 14 modified nucleotides per molecule. Modifications in tRNAs are responsible for their structure and their function. During stress, tRNAs have been shown to modulate and reprogram their tRNA status in order to fine-tune translational cellular responses.
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