Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay. [PDF]
Nat Commun, 2022 Martin S +5 more
europepmc +1 more source
iMeta, EarlyView.Genome‐resolved methylomics uncovers the first DNA methylation atlas of the dairy cow rumen microbiome. Microbial DNA methylation profiles diverge between low‐ and high‐ methane‐emitting dairy cows despite limited taxonomic differences. Differential methylation is linked to transcriptional variation in genes involved in carbon metabolism, hydrogen ...
Xinyue Zhang +9 more
wiley +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Journal of Chemical Technology &Biotechnology, EarlyView.Abstract BACKGROUND The choice of excipient is important in enhancing stability of liquid formulations containing lipid nanoparticles (LNPs) used in RNA delivery where the ability to survive unplanned excursions to higher and lower temperature and vibration is an important attribute.
Franz W Laurett Veras +2 more
wiley +1 more source
Landscape of Post-Transcriptional tRNA Modifications in Streptomyces albidoflavus J1074 as Portrayed by Mass Spectrometry and Genomic Data Mining. [PDF]
J Bacteriol, 2023 Koshla O +6 more
europepmc +1 more source
Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy +7 more
wiley +1 more source
Targeting metabolic rewiring might decrease spread of tumor cells: Mitochondrial tRNA modifications promote cancer metastasis. [PDF]
Signal Transduct Target Ther, 2022 Luu M, Visekruna A.
europepmc +1 more source
Making Sense of "Nonsense" and More: Challenges and Opportunities in the Genetic Code Expansion, in the World of tRNA Modifications. [PDF]
Int J Mol Sci, 2022 Lateef OM +4 more
europepmc +1 more source
Journal of the Science of Food and Agriculture, EarlyView.Abstract BACKGROUND Preventing chronic liver damage is essential for maintaining overall health and reducing the risk of serious liver diseases. Acetaminophen (APAP) overdose can lead to severe liver damage due to oxidative stress, and citrus fruits are rich in bioactive compounds that may have health benefits.
Po‐Yao Tsai +7 more
wiley +1 more source
Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa +2 more
wiley +1 more source