Results 41 to 50 of about 55,541 (288)

tRNA's modifications bring order to gene expression [PDF]

Current Opinion in Microbiology, 2008
The posttranscriptional modification of RNA is a significant investment in genes, enzymes, substrates, and energy. Advances in molecular genetics and structural biology indicate strongly that modifications of tRNA's anticodon domain control gene expression.
Estella M, Gustilo, Franck Ap, Vendeix, Paul F, Agris   +2 more
openaire   +2 more sources

Probing the diversity and regulation of tRNA modifications. [PDF]

Curr Opin Microbiol, 2020
Transfer RNAs (tRNAs) are non-coding RNAs essential for protein synthesis. tRNAs are heavily decorated with a variety of post-transcriptional modifications (tRNA modifications). Recent methodological advances provide new tools for rapid profiling of tRNA modifications and have led to discoveries of novel modifications and their regulation.
Kimura S, Srisuknimit V, Waldor MK.
europepmc   +4 more sources

Bacterial wobble modifications of NNA‐decoding tRNAs [PDF]

IUBMB Life, 2019
AbstractNucleotides of transfer RNAs (tRNAs) are highly modified, particularly at the anticodon. Bacterial tRNAs that read A‐ending codons are especially notable. The U34 nucleotide canonically present in these tRNAs is modified by a wide range of complex chemical constituents.
Emil M. Nilsson, Rebecca W. Alexander
openaire   +2 more sources

tRNA Modifications: Impact on Structure and Thermal Adaptation

Biomolecules, 2017
Transfer RNAs (tRNAs) are central players in translation, functioning as adapter molecules between the informational level of nucleic acids and the functional level of proteins.
Christian Lorenz, Christina E. Lünse, Mario Mörl   +2 more
doaj   +1 more source

Charting new territory: The Plasmodium falciparum tRNA modification landscape

Biomedical Journal
Ribonucleoside modifications comprising the epitranscriptome are present in all organisms and all forms of RNA, including mRNA, rRNA and tRNA, the three major RNA components of the translational machinery.
Benjamin Sian Teck Lee, Ameya Sinha, Peter Dedon, Peter Preiser   +3 more
doaj   +1 more source

tRNA Function and Dysregulation in Cancer

Frontiers in Cell and Developmental Biology, 2022
Transfer RNA (tRNA) is a central component of protein synthesis and plays important roles in epigenetic regulation of gene expression in tumors. tRNAs are also involved in many cell processes including cell proliferation, cell signaling pathways and ...
Tania Gupta, Mark G. Malkin, Mark G. Malkin, Suyun Huang, Suyun Huang, Suyun Huang   +5 more
doaj   +1 more source

Photoaffinity reagents for modification of aminoacyl‐tRNA synthetases [PDF]

FEBS Letters, 1974
Up to now, a few derivatives of aminoacyl-tRNA with a reactive group attached to the aminoacyl residue [l-4] and a reactive analog of an amino acid [4] have been used for the affinity labeling of aminoacyltRNA synthetases (EC 6.1 .l). For detailed investigation of the active centers of these enzymes, it is necessary to prepare tRNA analogs bearing ...
Budker, V.G., Knorre, D.G., Kravchenko, V.V., Lavrik, O.I., Nevinsky, G.A., Teplova, N.M.   +5 more
openaire   +2 more sources

Native tertiary structure and nucleoside modifications suppress tRNA's intrinsic ability to activate the innate immune sensor PKR. [PDF]

PLoS ONE, 2013
Interferon inducible protein kinase PKR is an essential component of innate immunity. It is activated by long stretches of dsRNA and provides the first line of host defense against pathogens by inhibiting translation initiation in the infected cell. Many
Subba Rao Nallagatla, Christie N Jones, Saikat Kumar B Ghosh, Suresh D Sharma, Craig E Cameron, Linda L Spremulli, Philip C Bevilacqua   +6 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

tRNA epitranscriptomics and biased codon are linked to proteome expression in Plasmodium falciparum

Molecular Systems Biology, 2018
Among components of the translational machinery, ribonucleoside modifications on tRNAs are emerging as critical regulators of cell physiology and stress response. Here, we demonstrate highly coordinated behavior of the repertoire of tRNA modifications of
Chee Sheng Ng, Ameya Sinha, Yaw Aniweh, Qianhui Nah, Indrakanti Ramesh Babu, Chen Gu, Yok Hian Chionh, Peter C Dedon, Peter R Preiser   +8 more
doaj   +1 more source