Results 31 to 40 of about 55,926 (239)

tRNA Metabolism and Lung Cancer: Beyond Translation

Frontiers in Molecular Biosciences, 2021
Lung cancer, one of the most malignant tumors, has extremely high morbidity and mortality, posing a serious threat to global health. It is an urgent need to fully understand the pathogenesis of lung cancer and provide new ideas for its treatment ...
Meng Bian, Shiqiong Huang, Dongsheng Yu, Zheng Zhou   +3 more
doaj   +1 more source

Posttranscriptional modification of tRNA in psychrophilic bacteria [PDF]

Journal of Bacteriology, 1997
Posttranscriptional modification in tRNA is known to play a multiplicity of functional roles, including maintenance of tertiary structure and cellular adaptation to environmental factors such as temperature. Nucleoside modification has been studied in unfractionated tRNA from three psychrophilic bacteria (ANT-300 and Vibrio sp.
J J, Dalluge, T, Hamamoto, K, Horikoshi, R Y, Morita, K O, Stetter, J A, McCloskey   +5 more
openaire   +2 more sources

Charging the code — tRNA modification complexes

Current Opinion in Structural Biology, 2019
All types of cellular RNAs are post-transcriptionally modified, constituting the so called 'epitranscriptome'. In particular, tRNAs and their anticodon stem loops represent major modification hotspots. The attachment of small chemical groups at the heart of the ribosomal decoding machinery can directly affect translational rates, reading frame ...
Rościsław Krutyhołowa, Karol Zakrzewski, Sebastian Glatt   +2 more
openaire   +3 more sources

On the Track of the Missing tRNA Genes: A Source of Non-Canonical Functions?

Frontiers in Molecular Biosciences, 2021
Cellular tRNAs appear today as a diverse population of informative macromolecules with conserved general elements ensuring essential common functions and different and distinctive features securing specific interactions and activities. Their differential
Ricardo Ehrlich, Ricardo Ehrlich, Marcos Davyt, Ignacio López, Cora Chalar, Mónica Marín   +5 more
doaj   +1 more source

Inosine modifications in human tRNAs are incorporated at the precursor tRNA level [PDF]

Nucleic Acids Research, 2015
Transfer RNAs (tRNAs) are key adaptor molecules of the genetic code that are heavily modified post-transcriptionally. Inosine at the first residue of the anticodon (position 34; I34) is an essential widespread tRNA modification that has been poorly studied thus far.
Torres, Adrian Gabriel, Piñeyro, David, Rodríguez-Escribà, Marta, Camacho, Noelia, Reina, Oscar, Saint-Léger, Adélaïde, Filonava, Liudmila, Batlle, Eduard, Ribas de Pouplana, Lluís   +8 more
openaire   +2 more sources

Charting new territory: The Plasmodium falciparum tRNA modification landscape

Biomedical Journal
Ribonucleoside modifications comprising the epitranscriptome are present in all organisms and all forms of RNA, including mRNA, rRNA and tRNA, the three major RNA components of the translational machinery.
Benjamin Sian Teck Lee, Ameya Sinha, Peter Dedon, Peter Preiser   +3 more
doaj   +1 more source

Photoaffinity reagents for modification of aminoacyl‐tRNA synthetases [PDF]

FEBS Letters, 1974
Up to now, a few derivatives of aminoacyl-tRNA with a reactive group attached to the aminoacyl residue [l-4] and a reactive analog of an amino acid [4] have been used for the affinity labeling of aminoacyltRNA synthetases (EC 6.1 .l). For detailed investigation of the active centers of these enzymes, it is necessary to prepare tRNA analogs bearing ...
Budker, V.G., Knorre, D.G., Kravchenko, V.V., Lavrik, O.I., Nevinsky, G.A., Teplova, N.M.   +5 more
openaire   +2 more sources

tRNA Function and Dysregulation in Cancer

Frontiers in Cell and Developmental Biology, 2022
Transfer RNA (tRNA) is a central component of protein synthesis and plays important roles in epigenetic regulation of gene expression in tumors. tRNAs are also involved in many cell processes including cell proliferation, cell signaling pathways and ...
Tania Gupta, Mark G. Malkin, Mark G. Malkin, Suyun Huang, Suyun Huang, Suyun Huang   +5 more
doaj   +1 more source

tRNA modifications and tRNA-derived small RNAs: new insights of tRNA in human disease. [PDF]

Cell Biol Toxicol
tRNAs are codon decoders that convert the transcriptome into the proteome. The field of tRNA research is excited by the increasing discovery of specific tRNA modifications that are installed at specific, evolutionarily conserved positions by a set of specialized tRNA-modifying enzymes and the biogenesis of tRNA-derived regulatory fragments (tsRNAs ...
Wu D, Li X, Khan FA, Yuan C, Pandupuspitasari NS, Huang C, Sun F, Guan K.   +7 more
europepmc   +3 more sources

Biosynthesis and function of tRNA modifications in Archaea

Current Opinion in Microbiology, 2011
tRNA modifications are important for decoding, translation accuracy, and structural integrity of tRNAs. Archaeal tRNAs contain at least 47 different tRNA modifications, some of them, including archaeosine, agmatidine, and mimG, are specific to the archaeal domain.
Microbiology and Cell Science Department, University of Florida, Gainesville, FL 32611, USA ( host institution ), Phillips, Gabriela, de Crécy-Lagard, Valérie   +2 more
openaire   +3 more sources