Results 11 to 20 of about 55,926 (239)
Genome recoding by tRNA modifications [PDF]
Open Biology, 2016 RNA modifications are emerging as an additional regulatory layer on top of the primary RNA sequence. These modifications are particularly enriched in tRNAs where they can regulate not only global protein translation, but also protein translation at the ...
Francesca Tuorto, Frank Lyko
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m1A Post‐Transcriptional Modification in tRNAs [PDF]
Biomolecules, 2017 To date, about 90 post‐transcriptional modifications have been reported in tRNA expanding their chemical and functional diversity. Methylation is the most frequent post‐transcriptional tRNA modification that can occur on almost all nitrogen sites of
Stephanie Oerum +3 more
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Biosynthesis and functions of sulfur modifications in tRNA [PDF]
Frontiers in Genetics, 2014 Sulfur is an essential element for a variety of cellular constituents in all living organisms. In tRNA molecules, there are many sulfur-containing nucleosides, such as the derivatives of 2‑thiouridine (s2U), 4-thiouridine (s4U), 2-thiocytidine (s2C), and
Naoki eShigi
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Temperature-Dependent tRNA Modifications in Bacillales. [PDF]
Int J Mol SciTransfer RNA (tRNA) modifications are essential for the temperature adaptation of thermophilic and psychrophilic organisms, as they control the rigidity and flexibility of transcripts. To further understand how specific tRNA modifications are adjusted to maintain functionality in response to temperature fluctuations, we investigated whether tRNA ...
Hoffmann A +7 more
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Unravelling Strain-Specific Modifications of Toxoplasma gondii tRNA and sncRNA Using LC-MS/MS
Microbiology Spectrum, 2023 Many RNA modifications have been detected in rRNA, tRNA and small noncoding RNA (sncRNA) as well as in low-abundance RNA species such mRNA. Although RNA modifications play roles in many cellular and biological processes in various domains of life ...
Wei Wang +8 more
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Decoding Codon Bias: The Role of tRNA Modifications in Tissue-Specific Translation [PDF]
International Journal of Molecular SciencesKuniyasu Niizuma +2 more
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Extracurricular Functions of tRNA Modifications in Microorganisms. [PDF]
Genes (Basel), 2020 Transfer RNAs (tRNAs) are essential adaptors that mediate translation of the genetic code. These molecules undergo a variety of post-transcriptional modifications, which expand their chemical reactivity while influencing their structure, stability, and functionality.
Edwards AM, Addo MA, Dos Santos PC.
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Disruption to tRNA Modification by Queuine Contributes to Inflammatory Bowel DiseaseSummary
Cellular and Molecular Gastroenterology and Hepatology, 2023 Backgrounds and Aims: Transfer RNA (tRNA) is the most extensively modified RNA in cells. Queuosine modification is a fundamental process for ensuring the fidelity and efficiency of translation from RNA to protein.
Jilei Zhang +5 more
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Loss of a Conserved tRNA Anticodon Modification Perturbs Plant Immunity. [PDF]
PLoS Genetics, 2015 tRNA is the most highly modified class of RNA species, and modifications are found in tRNAs from all organisms that have been examined. Despite their vastly different chemical structures and their presence in different tRNAs, occurring in different ...
Vicente Ramírez +8 more
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Probing the diversity and regulation of tRNA modifications. [PDF]
Curr Opin Microbiol, 2020 Transfer RNAs (tRNAs) are non-coding RNAs essential for protein synthesis. tRNAs are heavily decorated with a variety of post-transcriptional modifications (tRNA modifications). Recent methodological advances provide new tools for rapid profiling of tRNA modifications and have led to discoveries of novel modifications and their regulation.
Kimura S, Srisuknimit V, Waldor MK.
europepmc +4 more sources